Kevin S. Ikuta’s research while affiliated with University of California, Los Angeles and other places

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Publications (29)


mmc2 (1).pdf
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  • File available

February 2025

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38 Reads

Nicole Davis Weaver

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Gregory J. Bertolacci

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Emily Rosenblad

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[...]

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Mohsen Naghavi
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Global, regional, and national burden of suicide, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

February 2025

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478 Reads

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1 Citation

The Lancet Public Health

Background: Deaths from suicide are a tragic yet preventable cause of mortality. Quantifying the burden of suicide to understand its geographical distribution, temporal trends, and variation by age and sex is an essential step in suicide prevention. We aimed to present a comprehensive set of global, regional, and national estimates of suicide burden. Methods: We produced estimates of the number of deaths and age-standardised mortality rates of suicide globally, regionally, and for 204 countries and territories from 1990 to 2021, and disaggregated these results by age and sex. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 estimates of deaths attributable to suicide were broken down into two comprehensive categories: those by firearms and those by other specified means. For this analysis, we also produced estimates of mean age at the time of death from suicide, incidence of suicide attempts compared with deaths, and age-standardised rates of suicide by firearm. We acquired data from vital registration, verbal autopsy, and mortality surveillance that included 23 782 study-location-years of data from GBD 2021. Point estimates were calculated from the average of 1000 randomly selected possible values of deaths from suicide by age, sex, and geographical location. 95% uncertainty intervals (UIs) were derived from the 2·5th and 97·5th percentiles from a 1000-draw distribution. Findings: Globally, 746 000 deaths (95% UI 692 000–800 000) from suicide occurred in 2021, including 519 000 deaths (485 000–556 000) among males and 227 000 (200 000–255 000) among females. The age-standardised mortality rate has declined over time, from 14·9 deaths (12·8–15·7) per 100 000 population in 1990 to 9·0 (8·3–9·6) per 100 000 in 2021. Regionally, mortality rates due to suicide were highest in eastern Europe (19·2 [17·5–20·8] per 100 000), southern sub-Saharan Africa (16·1 [14·0–18·3] per 100 000), and central sub-Saharan Africa (14·4 [11·0–19·1] per 100 000). The mean age at which individuals died from suicide progressively increased during the study period. For males, the mean age at death by suicide in 1990 was 43·0 years (38·0–45·8), increasing to 47·0 years (43·5–50·6) in 2021. For females, it was 41·9 years (30·9–46·7) in 1990 and 46·9 years (41·2–52·8) in 2021. The incidence of suicide attempts requiring medical care was consistently higher at the regional level for females than for males. The number of deaths by suicide using firearms was higher for males than for females, and substantially varied by country and region. The countries with the highest age-standardised rate of suicides attributable to firearms in 2021 were the USA, Uruguay, and Venezuela. Interpretation: Deaths from suicide remain variable by age and sex and across geographical locations, although population mortality rates have continued to improve globally since the 1990s. This study presents, for the first time in GBD, a quantification of the mean age at the time of suicide death, alongside comprehensive estimates of the burden of suicide throughout the world. These analyses will help guide future approaches to reduce suicide mortality that consider a public health framework for prevention.









Citations (10)


... Y87.0" (20,21). This study incorporated suicide data from various sources, including vital registration (VR) records, survey results, verbal autopsy (VA) data, and surveillance systems, with further details available in other referenced materials (22). ...

Reference:

Prevalence, incidence, and Disability-Adjusted Life Years of self-harm and suicide mortality in the Middle East and North Africa: a sex-specific study based on Global Burden of Disease
Global, regional, and national burden of suicide, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

The Lancet Public Health

... The number of victims of diarrheal infections points to the magnitude of this public health problem. Predictors of the quality of individual treatment by medical health care include the cost, beliefs, and the severity of strain on the health of adults who make individual treatment decisions [11,12]. ...

Global, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990-2021, for 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021

The Lancet Infectious Diseases

... Larynx cancer continues to be a major global public health concern, with significant disparities in mortality trends across regions and countries [25,26]. This study provides a detailed analysis of larynx cancer mortality from 1990 to 2021 using data from the GBD 2021, revealing critical insights into the patterns and determinants of this disease. ...

The burden of diseases, injuries, and risk factors by state in the USA, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021

The Lancet

... A landmark trial published in 2024 demonstrated the efficacy of the HIV-1 capsid inhibitor lenacapavir, administered twice a year by subcutaneous injection, in preventing HIV acquisition among women and girls in South Africa and Uganda. (2) This long-acting drug offers a new tool for HIV prevention, but its success depends on affordability and accessibility for those at greatest risk. The sustainability of HIV prevention and treatment programs is threatened by funding challenges. ...

Global, regional, and national burden of HIV/AIDS, 1990–2021, and forecasts to 2050, for 204 countries and territories: the Global Burden of Disease Study 2021

... Through combined political, social, and economic efforts, substantial progress was made, but nevertheless only a few countries met these targets by 2020. Thus, in 2021, a new global strategy with a focus on inequalities was proposed by UNAIDS with the aim of reducing new HIV infections from 1.65 million to less than 370,000 per year and AIDS-related deaths from 718,000 to less than 250,000 per year [2,3]. The three interim targets from the 2015 strategy were raised to 95% diagnosed, 95% treated, and 95% suppressed. ...

Global, regional, and national burden of HIV/AIDS, 1990-2021, and forecasts to 2050, for 204 countries and territories: the Global Burden of Disease Study 2021

The Lancet HIV

... Of note, these states cover South, North, and Central Mexico. A total of 59 Newport strains (14.7%) and 50 Anatum strains (12.4%) were isolated from meat samples, aligning with previous reports showing that Salmonella serotypes are frequently associated with meat products, especially in urban areas with interconnected food supply chains [9,[54][55][56]. ...

Using priorities between human and livestock bacterial antimicrobial resistance (AMR) to identify data gaps in livestock AMR surveillance

BMC Infectious Diseases

... The global burden of ABR is a critical public health issue that threatens to undermine decades of medical progress. Resistant infections are responsible for hundreds of thousands of deaths annually, with projections suggesting this number could rise to 10 million by 2050 if no action is taken [7,8]. The economic impact is equally alarming, with costs expected to reach $100 trillion globally due to increased healthcare expenditures and lost productivity [9]. ...

Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050

... Musmar stressed that AMR must be included in all emergency and pandemic preparedness discussions, as it directly impacts global health with all One Health domains intricately interconnected [2]. She addressed how AMR is worsened in conflict zones, citing how war leading to significant environmental destruction, soil and water contamination, human displacement, and limited access to healthcare facilitate the exponential increase and rapid spread of resistant pathogens. ...

Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050

... To reduce your chances of exposure to these bacteria, don't drink lake or pond water, wash your hands often, avoid unsecured foods, and beware of cross-contaminants between foods. [9]. Several studies have been conducted on contamination of well water with intestinal bacteria and sewage, especially the spread IOP Publishing doi:10.1088/1755-1315/1183/1/012068 ...

Increasing air pollution and its impact on human health
  • Citing Data
  • September 2024

... This study reveals a high prevalence of tetra-, penta-, and hepta-resistant patterns in environmental and pork isolates, which poses a significant public health threat due to potential treatment failures after simple infections caused by MDR isolates. These findings were consistent with various global investigations demonstrating a high incidence of MDR patterns among Salmonella strains isolated from different sources [19,30]. The extensive use of antibiotics in the medical and veterinary sectors that resulted in a high AMR by exerting a selection pressure against the used antimicrobials. ...

Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050

The Lancet