Kenneth Sandnabba's research while affiliated with Åbo Akademi University and other places
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Publications (40)
Pheromones regulate social and reproductive behavior in most mammalian species. These effects are mediated by the vomeronasal and main olfactory systems. Effects of putative pheromones on human neuroendocrine activity, brain activity and attractiveness ratings suggest that humans may communicate via similar chemosignaling. Here we studied two sampl...
Prior research with selected clinical and forensic samples suggests associations between paraphilic sexual interests (e.g., exhibitionism and sexual sadism) and sexually coercive behavior. However, no study to date used a large, representative and genetically informative population sample to address the potential causal nature of this association....
Despite moderate heritability estimates, the molecular architecture of aggressive behavior remains poorly characterized. This study compared gene expression profiles from a genetic mouse model of aggression with zebrafish, an animal model traditionally used to study aggression. A meta-analytic, cross-species approach was used to identify genomic va...
Table S1 Associations between investigated SNPs, AUDIT scores and smoking.
Mouse models of aggression have traditionally compared strains, most notably BALB/cJ and C57BL/6. However, these strains were not designed to study aggression despite differences in aggression related traits and distinct reactivity to stress. This study evaluated expression of genes differentially regulated in a stress (behavioral) mouse model of a...
The multifaceted gut-brain peptide ghrelin and its receptor (GHSR-1a) are implicated in mechanisms regulating not only the energy balance but also the reward circuitry. In our pre-clinical models, we have shown that ghrelin increases whereas GHSR-1a antagonists decrease alcohol consumption and the motivation to consume alcohol in rodents. Moreover,...
Evolutionary theory suggests that the availability of environmental cues of biological relatedness (i.e., kinship cues) is an important predictor of both positive investment (e.g., altruism) and maltreatment (e.g., physical and sexual abuse) within families. Although several studies have supported these assumptions, many suffer methodological limit...
Aggressive behaviour is a major cause of mortality and morbidity. Despite of moderate heritability estimates, progress in identifying the genetic factors underlying aggressive behaviour has been limited. There are currently three genetic mouse models of high and low aggression created using selective breeding. This is the first study to offer a glo...
Child maltreatment is associated with adult sexually coercive behavior. The association may be causal or confounders that increase the risk of both childhood victimization and sexually coercive behavior might explain the observed links. We examined if childhood maltreatment was related to sexual coercion independently of familial (genetic or common...
Erectile dysfunction (ED) has been extensively studied in the past few decades, and significant advances have been made in understanding its etiology. Most cases of this type of dysfunction have an organic etiology, and ED occurs primarily in older men. However, relatively little is known about erectile problems in young men or about the interconne...
We explored if the disposition to react with aggression while alcohol intoxicated was moderated by polymorphic variants of the oxytocin receptor gene (OXTR). Twelve OXTR polymorphisms were genotyped in 116 Finnish men [aged 18-30, M = 22.7, standard deviation (SD) = 2.4] who were randomly assigned to an alcohol condition in which they received an a...
Previous research has indicated that serotonergic genes may influence ejaculatory function. Attempts to investigate effects of polymorphisms in serotonergic genes have been carried out, but so far, no study has conducted exploratory genotype analyses regarding the serotonin receptor 1A, 1B, and 2C subtypes, which have been hypothesized to mediate t...
There is little research estimating the occurrence of female sexual dysfunction (FSD) in women with same-sex sexual experience and none incorporating a key feature of standardized DSM-IV diagnoses-sexual distress.
To investigate the prevalence of FSD in women with and without same-sex sexual experience and whether any effects of same-sex sexual exp...
Johansson, A., Santtila, P., Corander, J., Jern, P., von der Pahlen, B., Varjonen, M. & Sandnabba, K. (2011). Controlling anger in self-reported sober and alcohol intoxicated states: Moderating effects of trait anger and alcohol consumption. Scandinavian Journal of Psychology 52, 382–388.
Retrospective self-reports about prior sober and alcohol int...
Recently, attempts to formulate valid and suitable definitions for (different subcategories of) premature ejaculation have resulted in substantial progress in the pursuit to gain knowledge about ejaculatory function. However, the association between ejaculatory dysfunction and different types of sexual activities has yet to be thoroughly investigat...
Clinicians' expertise in child sexual abuse (CSA) cases was explored by giving a questionnaire covering clinical experience, self-evaluated expertise, beliefs and attitudes about CSA and a trial material concerning CSA to 320 child mental health professionals. In the material the suggestiveness of the interview with the child was varied and one con...
Few studies have looked at prevalence estimates for female sexual dysfunctions in combination with personal distress, although existing diagnostic criteria for sexual disorders include both aspects. Further, the variation in female sexual function has been shown to be largely explained by unique nongenetic factors. Such factors may include partner...
Individual differences in parenting behaviors are due, in part, to genetic factors. In the present study, the authors sought to determine whether the degree of genetic influence varied according to the type of parental behavior under consideration. A population-based sample of 2,334 pairs of Finnish twins provided ratings on the physical affection,...
Recently, in anticipation of the Diagnostic and Statistical Manual of Mental Disorders V, much consideration has been given to the diagnostic criteria for premature ejaculation (PE). The scientific community is yet to agree not only on the etiology of PE, but also on the most suitable diagnosis and forms of treatment. It has been suggested that the...
Unlabelled:
Residential location of a criminal can be predicted statistically [M. Laukkanen, P. Santtila, Predicting the home location of a serial commercial robber, Forensic Sci. Int. 157 (2006) 71-82]. Examined were: accuracy of the technique for urban burglary series, correlations between way of committing burglary and distance and use of those...
A Child Sexual Abuse Attitude and Belief Scale was constructed and then answered by 242 child psychologists. Four CSA related attitude and belief subscales were identified through confirmatory factor analysis: (1) The Disclosure subscale reflecting favouring a disclosure at any cost; (2) The Pro-Child subscale reflecting unconditional belief in chi...
A number of different theoretical approaches to understanding the etiology of ejaculatory dysfunction have been proposed, but no behavior genetic study has yet, to our knowledge, been conducted to explore the genetic and environmental influences on ejaculatory dysfunction.
The aim of the present study was to explore the genetic and environmental ef...
Involvement of AMPA-type glutamate receptors in the regulation of social behavior has been suggested by experiments with mice deficient for the GluR-A subunit-containing AMPA receptors showing reduced intermale aggression. In the present study, effects of AMPA receptor antagonists on mouse social behavior towards unfamiliar Swiss-Webster males on a...
Behavioral observations as a matrix of probabilistic changes of postures and acts are multiple measurements that could introduce variability to statistical analysis. We propose the multimetric statistical algorithm that supplements the linear analysis of variance by pair correlation, factor and discriminant function analyses. Although these methods...
The Big Five Inventory (BFI) is a self-report measure designed to assess the high-order personality traits of Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness. As part of the International Sexuality Description Project, the BFI was translated from English into 28 languages and administered to 17,837 individuals from 56 nati...
The purpose of this study was to investigate whether clinicians investigating child sexual abuse (CSA) rely more on scientific knowledge or on clinical experience when evaluating their own expertise. Another goal was to check what kind of pre-trial beliefs the clinicians had. The connections between these different factors were investigated. A ques...
As part of the International Sexuality Description Project, a total of 17,804 participants from 62 cultural regions completedthe RelationshipQuestionnaire(RQ), a self-reportmeasure of adult romanticattachment. Correlational analyses within each culture suggested that the Model of Self and the Model of Other scales of the RQ were psychometrically va...
As part of the International Sexuality Description Project, 16,954 participants from 53 nations were administered an anonymous survey about experiences with romantic attraction. Mate poaching--romantically attracting someone who is already in a relationship--was most common in Southern Europe, South America, Western Europe, and Eastern Europe and w...
The purpose of this study was to investigate the effects of genetic and environmental factors, as well as their interaction, in the etiology of aggressive behavior in two mouse lines bidirectionally selected for offensive aggression. To this end, we raised the Finnish TA (aggressive) and TNA (nonagressive) selection lines either in isolation or in...
Gender differences in the dismissing form of adult romantic attachment were investigated as part of the International Sexuality Description Project-a survey study of 17,804 people from 62 cultural regions. Contrary to research findings previously reported in Western cultures, we found that men were not significantly more dismissing than women acros...
Evolutionary psychologists have hypothesized that men and women possess both long-term and short-term mating strategies, with men's short-term strategy differentially rooted in the desire for sexual variety. In this article, findings from a cross-cultural survey of 16,288 people across 10 major world regions (including North America, South America,...
In the present study the relative contributions of internal and external sources of variation in children's suggestibility in interrogative situations were examined. One hundred and eleven children (48 4- to 5-year-olds and 63 7- to 8-year-olds) were administered a suggestibility test (BTSS) and the most suggestible (N=36) and the least suggestible...
Citations
... It is probably true to say that the reason behind some Islamic instructions, regarding hijab and the observance of some issues, especially communication with distance between women and men, might be related to the connection of pheromones to the receptors, such that the pheromones of male and female hormone activate the sexual arousal when binding to their receptors in the opposite sex, not to the same sex or those who share the same mother or father. In other words, they do not activate the same familiar genetic structures (14). ...
... It has been proposed that b-cell translocation gene 2 (btg2) and ier2a are key regulators of vertebrate neural development (Moriya et al., 2016). Previous investigations associating btg2 deletion in zebrafish and mice with aberrant aggression raise the possibility that both genes are crucial for brain processes related to aggression (Malki et al., 2016;Liu et al., 2020). The vgf (VGF nerve growth factor-inducible), a neuropeptide involved in crucial neural processes such as synaptic plasticity, neurogenesis, and brain neurite growth, is produced by brain-derived neurotrophic and nerve growth factors (Mizoguchi et al., 2017;Takeuchi et al., 2018) and has been shown to have neuroprotective effects on retinal ganglion cells (Takeuchi et al., 2018). ...
... Deficiency of tryptophane hydroxylase and 5-day predation stress Tph2 +/− male mice Increased aggressive behaviours in males; reduced brain serotonin content, reduced expression of 5-HT6 receptor, GSK3-β overexpression [72] Tph2 +/− female mice Increased aggressive behaviours in females; reduced brain serotonin content, GSK3-β and myelin basic protein overexpression; deficient neuroplasticity, downregulation of synaptophysin [73] Another stress paradigm that is used to elicit aggression in experimental rodents is chronic mild stress [18,74]. Chronic unpredictable stress was found to provoke increased aggression in male BALB/C, CD1 and C57BL/6J mice, as shown in the resident-intruder test [51][52][53][54][55]. C57BL/6J mice exposed to a chronic mild stress paradigm showed increased offensive and aggressive behaviours in the resident-intruder test and the social dominance tube test [75]. ...
... A gyermekeket ért szexuális bűncselekmények motivációs és oksági háttere régóta a kutatások érdeklődésének fókuszában áll, mert a feltárt tényezők mind a kockázatbecslés, mind a prevenciós és intervenciós gyakorlat szempontjából kulcsfontosságúak (BAUR et al., 2016). ...
Reference: Pedofília és bűnözés
... A human genetic study that was focused on female patients with severe alcohol dependence in Sweden reported that two haploid genotypes of the GHSR gene were associated with smoking status [130]. Another study showed that the minor allele of the rs2948694 singlenucleotide polymorphism (SNP) was located in the GHSR-1A gene (GHSR), but none of the tested SNPs of the pre-proghrelin gene (GHRL) appeared to be associated with an increased severity of cigarette smoking [131]. ...
... Due to the inclusion of twins in the sample, responses regarding the frequency of childhood maltreatment and sexual orientation were compared to various Finnish population samples. (e.g., Albrecht et al., 2014) of the overall population. Our sample outcomes are pertinent to non-identical twins, as we noticed no statistically significant differences between our samples. ...
... Inflammation and immune functions were the most important pathways unveiled by the sPLS or sPLSDA analyses. Other transcriptomic studies conducted in mouse models of aggressiveness [60] or in zebrafish [61] but on brain tissues, led to the same conclusions. In mice prefrontal cortex of aggressive versus non-aggressive mice, the transcriptomic analysis uncovered NFKB and MAPK pathways which are known to be both involved in inflammation [60]. ...
... For example, in a representative Québec sample, child sexual abuse was associated with psychological, physical, and sexual violence among both males and females (Hébert et al., 2017). Finally, child maltreatment has been associated with experiencing sexual coercion or exploitation later in life (Forsman et al., 2015;Layne et al., 2014). ...
... As a popular measure of Big Five personalities, the BFI-44 includes 44 items that are rated on a 5-point Likert scale ranging from 1 (disagree strongly) to 5 (agree strongly). Prior studies have shown adequate validity and reliability of the BFI-44 in different Chinese samples [44][45][46]. The Cronbach's αs for BFI-44 subscales in this study were acceptable: extraversion (0.72), agreeableness (0.72), conscientiousness (0.80), neuroticism (0.78), and openness (0.78). ...
... [12]- [14]); but it is not clear if they emerge for the first time at that age or if they are revealed because they become more pronounced. These differences continue in the adult stage: it has been reported that whereas women tend to be higher in anxiety, men tend to be higher in avoidance [15], although the magnitude of the dissimilarity varies from small to moderate depending on the cultural region considered [16]. Other investigation [17] found significant effects in romantic attachment when anxiety and avoidance dimensions were divided into facets: avoidance into self-reliance and discomfort with closeness, and anxiety into neediness, preoccupation, and a rejected desire for closeness. ...