Ken A. Joy's scientific contributions

Publications (2)

Article
Full-text available
It is well established that inflammation and oxidative stress are key components of the pathology of Alzheimer's disease (AD), but how early in the pathological cascade these processes are involved or which specific molecular components are key, has not been fully elucidated. This paper describes the pharmacological approach to understand the molec...
Article
Considerable evidence exists that the brains of individuals with Alzheimer's disease are subject to elevated levels of oxidative stress, particularly in regions exhibiting pathological damage. A major contributor to this oxidative stress appears to be the inflammatory process. Activation of rodent microglial cells by LPS or beta-amyloid peptide res...

Citations

... Edaravone, another free radical scavenger, quenches active oxygen and traps hydroxyl radicals and has been used in clinical studies (Watanabe et al., 2008;Ikeda and Iwasaki, 2015;Bhandari et al., 2018;Ishii et al., 2018). Also, EUK-134 has been used to investigate the role of oxidative stress in neurodegenerative disease (Anderson et al., 2001). ...
... Mn SOD and catalase are the antioxidants involved in the endogenous defence mechanism of ROSmediated cardiac injury. EUK has shown beneficial effects in many in vivo models for several neurological conditions such as degenerative disorders, stroke and other forms of excitotoxic and ischemic injury [5][6][7][8][9][10][11][12], diabetes [13], and also radiation injury [14]. The use of EUK-134 for the prevention of cardiac hypertrophy has received little attention. ...