Kelsey L. Pomykala's research while affiliated with University Hospital Essen and other places

Publications (34)

Preprint
Full-text available
Data has become the most valuable resource in today's world. With the massive proliferation of data-driven algorithms, such as deep learning-based approaches, the availability of data is of great interest. In this context, high-quality training, validation and testing datasets are particularly needed. Volumetric data is a very important resource in...
Preprint
Full-text available
Objectives: Present a novel deep learning-based skull stripping algorithm for magnetic resonance imaging (MRI) that works directly in the information rich k-space. Materials and Methods: Using two datasets from different institutions with a total of 36,900 MRI slices, we trained a deep learning-based model to work directly with the complex raw k-sp...
Article
Full-text available
Deep learning has remarkably impacted several different scientific disciplines over the last few years. For example, in image processing and analysis, deep learning algorithms were able to outperform other cutting-edge methods. Additionally, deep learning has delivered state-of-the-art results in tasks like autonomous driving, outclassing previous...
Article
The COVID-19 pandemic resulted in an unprecedented and unexpected challenge for societies and healthcare systems, including nuclear medicine providers. This article summarizes the major events imposed on nuclear medicine by COVID-19 from a global perspective, focuses on the major lessons learned regarding attitude, medical procedures, organizationa...
Article
Full-text available
Objectives: Prostate-specific membrane antigen (PSMA) PET/computed tomography (CT) is a novel imaging tool with an evolving role in the management of prostate cancer. This study aims to retrospectively evaluate the impact of 68Ga-PSMA PET/CT on prostate cancer staging and definitive radiation therapy planning. Methods: Between April 2015 and Jun...
Article
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Introduction: Fixed-dose pembrolizumab (200 mg abs., d1, q3w) for the treatment of malignant pleural mesothelioma did not result in survival benefit in the phase 3 PROMISE-meso trial compared to 2nd-line chemotherapy. Due to lack of validated imaging response criteria, responder-subgroups with potential survival benefit have not yet been identified...
Article
Full-text available
Purpose: To determine the relationship between serum prostate-specific antigen (PSA) level categories (< 5; 5-10; 10-20;>20 ng/ml) and the incidence of bone metastases detected by total-body 68Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT and to assess if expanding the 68Ga-PSMA-11 PET/CT imaging field to include the vertex and lower extre...
Article
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Purpose of review To describe the imaging findings of tuberculosis with different imaging modalities, as well as the current usage and importance of imaging tuberculosis in resource-limited settings. Recent findings Primary pulmonary tuberculosis can manifest as lung parenchymal disease, lymphadenopathy, pleural effusion, and/or miliary disease. D...
Chapter
Tuberculosis is an ancient infectious disease caused by Mycobacterium tuberculosis. When choosing an x‐ray imaging device system in the global health setting, hospitals and clinics must consider how the images will be obtained and transferred. As for the way images are obtained, chest x‐ray information technology has been advancing over the years a...
Article
According to SEER Cancer Statistics Review there are around 165,000 new prostate cancer cases estimated in 2018 accounting for 9.5% of all newly diagnosed cancers. Accurate staging of primary prostate cancer is important for therapy selection (local vs systemic). Recent developments in molecular imaging may significantly impact staging procedures a...
Article
Full-text available
Because only pathologic examination can confirm the presence or absence of malignant disease in cancer patients, a certain rate of misinterpretation in any kind of imaging study is inevitable. For the accuracy of interpretation to be improved, determination of the nature, causes, and magnitude of this problem is needed. This study was designed to c...
Article
Percutaneous image-guided ablation is a technique for maintaining local control of metastatic lung lesions that may, in selected patients, confer a survival benefit over no treatment or systemic therapy alone. Although the currently accepted treatment for oligometastatic pulmonary disease is surgical resection, the existing body of literature, incl...
Article
Musculoskeletal tumors comprise a multitude of tumor entities with different grades of malignancy, biological behavior, and therapeutic options. Positron emission tomography (PET) using the glucose analog [18F]fluorodeoxyglucose (FDG) is an established imaging modality for detection and staging of cancer, despite some shortcomings. Numerous studies...
Article
Aim: To elucidate techniques most commonly used for interpreting oncologic PET/CT studies. This survey forms a basis to work on standardization of reporting and highlight the most important issues to be addressed. Methods: A web-based survey of 329 PET/CT imaging specialists was designed with the intent to determine image interpretation patterns...
Article
Full-text available
The role of [(18)F]fluorodeoxyglucose ([(18)F]FDG) PET in staging of sarcoma is well established. The aim of this preclinical study was to compare [(18)F]fluorothymidine ([(18)F]FLT) PET to [(18)F]FDG PET regarding early metabolic changes of sarcoma in the course of targeted cancer therapy. SCID mice bearing sarcoma A673 xenotransplants were used f...
Article
Background Amino acid transport imaging with (18)F-FDOPA PET is increasingly used for detection of glioblastoma recurrence. However, a standardized image interpretation for (18)F-FDOPA brain PET studies has not yet been established. This study compares visual and semiquantitative analysis parameters for detection of tumor recurrence and correlates...
Article
Full-text available
To examine relationships following adjuvant chemotherapy between circulating pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints in early stage breast cancer patients. 33 breast cancer patients who had completed initial treatment (surgery, ± radiation, 23 chemotherapy, 10 no chemotherapy) obtained resting (18)F-FDG PE...
Article
Cognitive complaints following cancer and cancer therapy are common. Many studies have investigated the effects of chemotherapy on the brain. However, the mechanisms for the associated cognitive impairment are not well understood. Some studies have also included brain imaging to investigate potential neurological substrates of cognitive changes. Th...
Article
Full-text available
Background: The clinical utility of modern hybrid imaging modalities for detecting recurrent bone or soft tissue sarcoma remains to be determined. In this report, the authors present a clinical study on the diagnostic accuracy and incremental value of integrated (18) F-fluorodeoxyglucose positron emission tomography/computed tomography ((18) F-FDG...
Article
Full-text available
AIMS: Caregiver distress can affect mood and cognition. Meditation can be used to reduce stress. This pilot study explored whether yogic meditation could change regional cerebral metabolism in distressed caregivers. METHODS: Nine dementia caregivers were randomized to undergo meditation training compared with relaxation for 12 min per day for 8 wee...
Article
The majority of cancer patients treated with chemotherapy complain of fatigue and/or cognitive dysfunction. Although many patients experience improvement shortly after completion of treatment, a substantial number of patients may continue to be symptomatic for years or even decades after their last dose of chemotherapy. This review focuses on the s...
Conference Paper
Objectives: To compare patterns of regional brain metabolism at baseline and 1yr later in BC patients who underwent endocrine therapy and those who did not. Methods: 28 subjects recently diagnosed with BC and not yet on endocrine therapy received baseline resting brain FDG-PET scans. Subsequently, 17 subjects(age 51.6 ± 8.8) received endocrine the...
Conference Paper
Objectives: The MCI-ID trial is a Medicare-sponsored prospective randomized study specifically aimed at acquiring rigorously controlled data with which to address the impact of brain PET scan results on 1)early evaluation and management by referring physicians of Medicare beneficiaries suffering from Mild Decline in Cognition (MDC) and 2)long-term...
Article
In the past, enormous public and private investments have been made to reduce cancer incidence and mortality. Despite some improvements over the last 10 years, the overall outcome of the "war on cancer" has been disappointing. Among the reasons for this limited success is our inability to determine, whether the therapeutic target is present, and wh...
Conference Paper
Objectives: We examined the prospective relationship between peripheral markers of proinflammatory cytokine activity, measured at the completion of adjuvant chemotherapy in early stage breast cancer and long-term changes in regional cerebral metabolism. Methods: 14 subjects, after surgery and prior to initiating endocrine therapy, underwent brain...
Conference Paper
Objectives: To examine effects of endocrine and chemotherapy on brain metabolism in newly diagnosed breast cancer patients in response to growing recognition that a sizeable minority of these patients report and/or demonstrate cognitive compromise. Methods: Subjects(n=15) recently diagnosed with breast cancer and not yet on endocrine therapy were...
Conference Paper
Objectives: The completion time for the Trails B test represents an objective neuropsychologic measure of timed visuomotor tracking tasks that is sensitive to deficits in executive ability, and has been previously identified to be worse in pediatric patients treated with chemotherapy for cancer (Kingma et al, 2002). We examined regional brain metab...
Conference Paper
Objectives: To examine relationships between self-reported cognitive complaints and regional cerebral activity in patients recently exposed to adjuvant chemotherapy. Methods: Subjects (n=30) recently diagnosed with breast cancer and not yet on endocrine therapy were prospectively recruited; 21 had completed adjuvant chemotherapy while 9 had none....

Citations

... Missed undiagnosed cases of diabetes and inability to efficiently detect high-risk individuals early are the main issues in clinic, that scientific research is yet to resolve. To address this problem, it seems reasonable to use machine learning and deep learning methods that have created opportunities to improve medical data processing, which is confirmed by numerous studies [3,4]. Such methods as support vector machine (SVM), random forest (RF), and extreme gradient boosting (XGBoost) were successfully used for predicting the outcomes of hypertension [5]. ...
... En un país como Venezuela, como prerrequisito para comprender la esencia de futuras reformas en la educación y práctica de la medicina, será necesario tomar en cuenta, por una parte, las propiedades inherentes a un sistema de atención sanitaria digital. Estas propiedades, se basan en principios propios de sistemas complejos, como la descentralización, autoorganización y autorregulación, entre otros, que son también, típicos del pensamiento holístico aplicado a la salud (McGill et al., 2021), en un mundo cada vez más interdependiente e híper conectado como lo demostró la pandemia COVID-19 (Freudenberg et al., 2022). Por otra parte, también será necesario considerar el efecto de experimentos naturales de autoorganización, un concepto cada vez más contra intuitivo y difícil de asimilar (Gross & Blasius, 2008;Toda et al., 2018), cuya validez en este trabajo, queda demostrada en la práctica en el Capítulo VII, a la luz de la teoría de la innovación, mediante las experiencias prácticas de los autores, en proyectos "inviables" o improbables de realizar en Venezuela, como podría ser esta propuesta de medicina digital. ...
... Already during the first evaluations, the modality proved able to assess responders and non-responders to therapy, even at early time points. 66,[68][69][70][71][72][73][74] The use of either metabolic response criteria, that is, EORTC (European Organization for Research and Treatment of Cancer) and PERCIST (PET Response Criteria in Solid Tumors) [75][76][77][78] or semi-quantitative and volumetric analyses, including metabolic tumor volume (MTV) and total lesion glycolysis (TLG), allowed predicting response and patients prognosis. 66,68,[69][70][71][72][73][74]79 Similarly though to initial staging, [ 18 F]FDG PET/CT evaluation after therapy is negatively impacted by previous talc pleurodesis, especially in case of volumetric computation of metabolically avid lesions. ...
... While the incidence of bone metastases correlates with the PSA level, bone metastases also occur in patients with serum PSA level < 5 ng/mL [100]. A retrospective analysis found PSMA-positive bone lesions in 12 of 93 patients (13%) who underwent initial staging, 40 of 225 (20%) of patients with BCR and in 49 of 70 patients (70%) who underwent restaging of M1 disease [100]. ...
... However, radiographs are often inadequate for making the diagnosis of PTB because they have poor sensitivity for detecting mediastinal and hilar lymphadenopathy and have little specificity in characterizing parenchymal and pleural lesions [1,[7][8][9]. CT remains the gold standard for the radiological diagnosis of PTB; it can define early features of TB (lymphadenopathy, nodules, small pleural effusion) before these become detectable in CXR [7][8][9][10]. However, CXR and especially CT cannot be used routinely and repeatedly in children for obvious reasons of radiation protection [11]. ...
... [8,9] Ga-68 PSMA agents are proven to have a role in initial staging, response assessment, biochemical recurrence in castration-resistant prostate cancer, and radiotherapy planning. [10][11][12][13] In this case, solitary brain metastasis was found in the setting of normal PSA levels. So it was initially reported as PSMA-RADS 3C lesion. ...
... 77 Examples of improved detection of recurrent tumors using FET PET are shown in Figures 4 and 5. Similar results have also been observed using FDOPA. 78,79 The feasibility and usefulness of MET, FET and FDOPA PET for assessment of treatment response have been demonstrated in several studies ( Figure 6). The currently available data suggest that a reduction of amino acid uptake of a glioma is a sign of a response to treatment. ...
... A lthough the adverse effects of anticancer chemotherapy on the brain metabolism have been long observed, [1][2][3] their strength and precise location remain unclear, as differences in the sampling and experimental methods prevent studies from being consistently compared. Among the side effects, cerebrovascular accident, 4-10 psychiatric disorders, 11,12 functional connectivity, [13][14][15] memory, neurocognitive and motor skills impairments 7,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] appear to be the most frequent findings associated to these therapies, corroborated by clinical data and neuropsychological tests. ...
... Interestingly, in a previous survey study among 663 referring physicians on their experience with the interpretation of oncological FDG-PET/CT studies, perceived misinterpretation rates ranged from 5% to 20%, according to 59.3% of the participants [7]. Overinterpretation rather than underinterpretation was more frequently encountered according to the referring physicians (68.9% vs. 8.7%, respectively) [7]. ...
... In selected cases of oligometastatic disease (i.e. with metastases confined to one or few sites), local treatments may prolong survival and more rarely used for symptom palliation [6]. ...