Kelly A. Deabold's research while affiliated with University of Florida and other places

Publications (4)

Article
Full-text available
Cannabidiol (CBD)-rich hemp extract use is increasing in veterinary medicine with little examination of serum cannabinoids. Many products contain small amounts of Δ9-tetrahydrocannabinol (THC), and precursor carboxylic acid forms of CBD and THC known as cannabidiolic acid (CBDA) and tetrahydrocannabinolic acid (THCA). Examination of the pharmacokin...
Article
Full-text available
A 2-year-old male neutered domestic shorthair cat from Florida, USA, presented with a one-month history of multiple subcutaneous nodules affecting the entire body. Dermatohistopathology revealed nodular to diffuse, eosinophilic, histiocytic, and mastocytic dermatitis and panniculitis with collagen flame figures, and many nematode larvae and adults...
Article
Cannabinoids hold promise for treating health problems related to inflammation and chronic pain in dogs, in particular cannabidiol (CBD), and its native acid derivative cannabidiolic acid (CBDA). Information regarding systemic delivery of cannabinoids through transdermal routes is sparse. The purpose of this study was to determine pharmacokinetics...
Article
Full-text available
The use of CBD-rich hemp products is becoming popular among pet owners with no long-term safety data related to consumption in adult dogs and cats. The purpose of this study was to determine the single-dose oral pharmacokinetics of CBD, and to provide a preliminary assessment of safety and adverse effects during 12-week administration using a hemp-...

Citations

... Treatments were divided evenly between the two daily concentrate meals, top-dressed and thoroughly mixed immediately prior to feeding. Levels of CBD supplementation were determined based on the previous literature in horses [15] and other species, using up to 1.5 mg CBD/kg BW [5,7,16,17] to avoid negative implications on liver health. An oil-based formulation was chosen due to ease of administration and higher bioavailability when compared to solid-based formulations [5,[18][19][20]. ...
... It was also reported from the puma (Felis concolor) in Brazil and Florida, and the ocelot (Felis pardalis) in Venezuela (summarised by Orihel and Isbey (1990)). Genetically they are more similar to D. immitis than D. repens (Wyatt et al. 2020). Moreover, it was documented in domestic cats and a human where it was removed from the orbit Isbey 1990, Wyatt et al. 2020). ...
... These pharmacokinetic differences also became apparent when a transdermal CBD-CBDA-rich extract was used in dogs, where serum concentrations of CBD, CBDA, THC, and its acid derivative tetrahydrocannabinolic acid (THCA) were examined. A 4 mg/kg dose of total cannabinoids twice daily resulted in appx 10 ng/ml of CBD, 21-32 ng/ml of CBDA, trace amounts of THCA, and unquantifiable amounts of THC in serum at the end of 1-2 weeks of treatment, concluding that CBDA and THCA were absorbed better systemically (32). In escalated doses, cannabis oils, including a CBD-predominant oil (2.8-30.5 mg/kg CBD + 0.1-1.1 mg/kg THC), a THC-predominant oil (3.8-41.5 mg/kg THC) and a CBD/THC-predominant oil (1.2-13 mg/kg CBD + 0.8-8.4 ...
... The increase in serum ALP levels were seen in dogs at 2 mg CBD/kg BW and at 2.5 mg CBD/kg BW [5,6]. Increases in ALT serum levels were reported in mice at 615 mg CBD/kg BW and in cats at 2 mg CBD/kg BW [4,7]. These studies indicate that CBD may have the potential for dose-dependent liver injury. ...