Keisuke Nomoto’s scientific contributions

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Publications (1)

Linkage of changes in Children's Depression Rating Scale‐Revised (CDRS‐R) total score with Clinical Global Impression of Improvement (CGI‐I) scores for studies integrated. Each line shows: Week 1 in blue line; Week 2 in red line; Week 3 in green line; Week 4 in brown line; Week 6 in purple line; Week 8 in yellow green line.
Linkage of changes in Children's Depression Rating Scale‐Revised (CDRS‐R) total score with Clinical Global Impression of Improvement (CGI‐I) scores for weeks integrated. Each line shows: Study 0600B1‐382‐US in brown line; Study 0600B1‐394‐US in green line; Study A0501001in blue line; Study A0501017 in red line.
Linkage of changes in Children's Depression Rating Scale‐Revised (CDRS‐R) total score with Clinical Global Impression of Improvement (CGI‐I) scores for studies/weeks integrated. Equated score (blue line) is shown together with 2.5% point (red dotted line) and 97.5% point (green dotted line) calculated by bootstrap method.
Linkage of changes in Children's Depression Rating Scale‐Revised (CDRS‐R) total score with Clinical Global Impression of Improvement (CGI‐I) scores by (A) children (<12 years old) and (B) adolescent (≥12 years old) for studies/weeks integrated. Equated score (blue line) is shown together with 2.5% point (red dotted line) and 97.5% point (green dotted line) calculated by bootstrap method.
Clinical implication of children's depression rating scale‐revised score: Linking the children's depression rating scale‐revised score and clinical global impression using patients data from clinical trials
  • Article
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August 2023

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57 Reads

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2 Citations

Hiroki Yoshimatsu

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Shingo Higa

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Keisuke Nomoto

Background and Aims The Children's Depression Rating Scale‐Revised (CDRS‐R) score has been widely used to assess the severity of major depression in children and adolescents; however, the clinical implications of changes in the CDRS‐R score remain unclear. We evaluated these clinical implications by assessing the relationship between changes in the CDRS‐R score and changes in the Clinical Global Impression of Improvement (CGI‐I), in clinical research on major depression. Methods We used data from four clinical trials involving two antidepressants and evaluated the relationship between CDRS‐R score changes and the CGI‐I score using the equipercentile linking method. Results CDRS‐R score changes corresponding to a minimally improved (score of 3) CGI‐I score was approximately 14 points. Conclusion Our findings from the linking analyses are useful for interpreting the clinical implications of changes in the CDRS‐R score.

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Citations (1)

... We deemed a 6-point difference on the CDRS-R clinically meaningful, based on influential trials in adolescent depression. While benchmarks vary-for example, Merry et al 62 used a 5.5-point non-inferiority margin and Yoshimatsu et al 63 suggest a 14-point change for minimal improvementour 6-point choice is close to the 7-point threshold they consider relevant. This 6-point difference corresponds to a standardised mean difference of 0.5, a common threshold for superiority in clinical trials. ...

Reference:

Single-blinded, randomised, parallel-group, controlled trial comparing the efficacy and cost-effectiveness of therapist- and self-guided internet-delivered behavioural activation versus treatment as usual for adolescents with mild to moderate depression: study protocol
Clinical implication of children's depression rating scale‐revised score: Linking the children's depression rating scale‐revised score and clinical global impression using patients data from clinical trials
Hiroki Yoshimatsu

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·

Shingo Higa

·

Keisuke Nomoto