Katy Vincent's research while affiliated with Oxford University Hospitals NHS Trust and other places

Publications (39)

Article
Full-text available
Chronic pain induced by endometriosis is a maladaptive pain experienced by half of women with this disease. The lack of pharmacological treatments suitable for the long-term relief of endometriosis-associated pain, without an impact on fertility, remains an urgent unmet need. Progress has been slowed by the absence of a reproducible rodent endometr...
Preprint
Full-text available
Study question: Do subgroups of women with chronic pelvic pain (CPP) report different clinical symptoms and differing impact of pain on their quality of life? Summary answer: Clinical profiles of women with CPP show variability of clinical symptoms both within and between subgroups. However, there is an obvious negative impact of pain on the patien...
Article
Full-text available
Endometriosis is a chronic condition that affects ~10% of women globally. Its symptoms include chronic pelvic pain, heavy periods and tiredness/fatigue, which have been associated with poorer quality of life and mental health. We aim to explore the impact of the COVID-19 pandemic on pain and fatigue symptoms and their interactions with the impact o...
Article
Full-text available
Background IMI2-PainCare-BioPain-RCT2 is one of four similarly designed clinical studies aiming at profiling a set of functional biomarkers of drug effects on specific compartments of the nociceptive system that could serve to accelerate the future development of analgesics. IMI2-PainCare-BioPain-RCT2 will focus on human spinal cord and brainstem a...
Preprint
Full-text available
Objectives Chronic pelvic pain is common, poorly understood, and many women suffer for years without proper diagnosis and effective treatment. The Translational Research in Pelvic Pain (TRiPP) project takes a phenotyping approach, with a particular focus on endometriosis-associated pain (EAP) and bladder pain syndrome (IC/BPS), to improve our funda...
Article
Full-text available
The aim of this study was to develop and refine a heterologous mouse model of endometriosis-associated pain in which non-evoked responses, more relevant to the patient experience, were evaluated. Immunodeficient female mice (N = 24) were each implanted with four endometriotic human lesions (N = 12) or control tissue fat (N = 12) on the abdominal wa...
Article
Full-text available
Background Few new drugs have been developed for chronic pain. Drug development is challenged by uncertainty about whether the drug engages the human target sufficiently to have a meaningful pharmacodynamic effect. IMI2-PainCare-BioPain-RCT1 is one of four similarly designed studies that aim to link different functional biomarkers of drug effects o...
Article
Full-text available
Background: Pain is one of the primary symptoms of endometriosis, a chronic inflammatory condition characterised by the presence of endometrial tissue outside the uterus. Endometriosis-associated pain is commonly considered as nociceptive in nature, but its clinical presentation suggests that it might have neuropathic-like properties in a subgroup...
Article
Full-text available
Endometriosis is a chronic condition affecting ~10% of women globally. Little is known about the impact of the coronavirus disease 2019 (COVID-19) pandemic on their care. This brief report is aimed to explore the impact of COVID-19 on the care of people with endometriosis around the world, their priorities in relation to their clinical care during...
Preprint
Full-text available
Objective To explore the impact of the COVID-19 pandemic on pain and fatigue symptoms and their interactions with the impact on mental health in people with endometriosis. Design Global cross-sectional survey. Setting Online survey. Sample A total of 4717 adults with a surgical or radiological diagnosis of endometriosis. Methods An online global st...
Article
Full-text available
Background IMI2-PainCare-BioPain-RCT3 is one of four similarly designed clinical studies aiming at profiling a set of functional biomarkers of drug effects on the nociceptive system that could serve to accelerate the future development of analgesics, by providing a quantitative understanding between drug exposure and effects of the drug on nocicept...
Article
Postoperative pain management is still insufficient, leading to major deficits, including patient suffering, impaired surgical recovery, long-term opioid intake, and post-surgical chronic pain. Yet, identifying the best treatment options refers to a heterogeneous outcome assessment in clinical trials, not reflecting relevant pain-related aspects af...
Article
Full-text available
Endometriosis (ENDO) and interstitial cystitis/bladder pain syndrome (IC/BPS) are chronic pain conditions for which better treatments are urgently needed. Development of new therapies with proven clinical benefit has been slow. We have conducted a review of existing preclinical in vivo models for ENDO and IC/BPS in rodents, discussed to what extent...
Article
Full-text available
Background Endometriosis (where endometrial-like tissue is found outside the uterus) affects ~ 176 million women worldwide and can lead to debilitating pelvic pain. Three subtypes of endometriosis exist, with ~ 80% of women having superficial peritoneal endometriosis (SPE). Endometriosis is diagnosed by laparoscopy and, if SPE is found, gynaecologi...
Article
Background Chronic pelvic pain affects 2–24% of women worldwide, and evidence for medical treatments is limited. Gabapentin is effective in treating some chronic pain conditions, but its effect on central pain processing is unknown. Objectives To test the hypothesis that gabapentin can reduce pain and improve physical and emotional functioning in...
Article
Full-text available
Background Chronic pelvic pain affects 2–24% of women worldwide and evidence for medical treatments is scarce. Gabapentin is effective in treating some chronic pain conditions. We aimed to measure the efficacy and safety of gabapentin in women with chronic pelvic pain and no obvious pelvic pathology. Methods We performed a multicentre, randomised,...
Article
Full-text available
Background: Chronic pelvic pain affects 2–24% of women worldwide and evidence for medical treatments is scarce. Gabapentin is effective in treating some chronic pain conditions. We aimed to measure the efficacy and safety of gabapentin in women with chronic pelvic pain and no obvious pelvic pathology. Methods: We performed a multicentre, randomised...
Article
Full-text available
Background: Chronic pelvic pain affects 2-24% of women worldwide and evidence for medical treatments is scarce. Gabapentin is effective in treating some chronic pain conditions. We aimed to measure the efficacy and safety of gabapentin in women with chronic pelvic pain and no obvious pelvic pathology. Methods: We performed a multicentre, randomi...
Preprint
Full-text available
Background: Pain is one of the primary symptoms of endometriosis, a chronic inflammatory condition characterised by the presence of endometrial tissue outside the uterus. Endometriosis-associated pain is commonly considered as nociceptive in nature but its clinical presentation suggests that it might have neuropathic-like properties in a subgroup o...
Article
Full-text available
The care of patients with endometriosis has been complicated by the coronavirus disease 2019 (COVID-19) pandemic. Medical and allied healthcare appointments and surgeries are being temporarily postponed. Mandatory self-isolation has created new obstacles for individuals with endometriosis seeking pain relief and improvement in their quality of life...
Preprint
Full-text available
The care of patients with endometriosis has been complicated by the COVID-19 pandemic. Medical and allied healthcare appointments and surgeries are being temporarily postponed. Mandatory self-isolation has created new obstacles for individuals with endometriosis seeking pain relief and improvement in their quality of life. Anxieties may be heighten...
Article
Based on Rapid Response: https://www.bmj.com/content/365/bmj.l4035/rr-0
Article
Full-text available
Background: Pregnancy-induced analgesia is known to occur in association with the very high levels of estradiol and progesterone circulating during pregnancy. In women with natural ovulatory menstrual cycles, more modest rises in these hormones occur on a monthly basis. We therefore hypothesized that the high estradiol high progesterone state indic...
Article
Although pain is one of the main symptoms women with endometriosis present with, there is poor correlation between symptom severity and disease burden and the underlying biological mechanisms by which pain arises are still only poorly understood. We briefly review the neurobiology of pain before considering mechanisms that may be specifically relev...
Article
Full-text available
Introduction: Chronic pelvic pain (CPP) affects more than 1 million UK women with associated healthcare costs of £158 million annually. Current evidence supporting interventions when no underlying pathology is identified is very limited and treatment is frequently inadequate. Gabapentin (a GABA analogue) is efficacious and often well tolerated in...
Data
Full Trial protocol (approved by ethics committee). (PDF)

Citations

... The heterologous model (xenograft) is obtained by implanting a portion of an endometrial biopsy from a human donor into an immunosuppressed mouse [52,53]. Although the implantation rate is around 30%, this percentage can increase to 100% when implants are sewn or glued using tissue adhesive [52]. ...
... 46 47 Among endometriosis patients with central sensitization, the removal of the endometriotic lesions is unlikely to result in adequate pain remediation owing to continued activation of the central nervous system. 96 97 Thus, endometriosis associated pain does not neatly fall into one of the three main categories of chronic pain (that is, nociceptive, neuropathic, or nociplastic), [98][99][100] and it likely has a mixed pain phenotype or sits somewhere along a continuum of these pain phenotypes. For example, some patients have primarily nociceptive or neuropathic pain, others have primarily nociplastic pain, and the rest have a mixed phenotype with variable contributions of nociceptive, neuropathic, and nociplastic pain. ...
... Moreover, endometriosis patients experienced increased pain symptoms such as dysmenorrhea [18], and increased mental health symptoms such as anxiety [2] and depression [3] as a consequence of the pandemic. Whether the worsening of these symptoms was directly as a result of SARS-CoV-2 infection, or indirectly because of decreased access to medical care and medication [19], or a combination of both, there is little evidence available to substantiate these observations. Endometriosis is a disease due to endocrine and immune dysregulation [27], and its pathogenesis is poorly understood. ...
... Homologous models (allograft) of endometriosis are obtained by implanting a small portion of uterus tissue at the intestinal mesenteric vessels and/or at the peritoneal wall or injecting resuspended tissue into the peritoneal cavity from the donor to recipient animal. The most commonly used method is inserting a fragment of the uterine horn from the donor (autologous or from in-bred strain to avoid host graft reaction), which is sutured or glued with tissue adhesive to the recipient [45]. ...
... The current study is the first study that investigated the characteristics of PROSPERO registrations of SRs on regional anesthesia for perioperative pain management. Perioperative pain is still not managed well, leading to severe consequences: patient suffering, impaired recovery, opioid dependence and development of chronic pain [14]. This study showed that, over the 10-year period, SRs of randomized controlled trials in regional anesthesia for perioperative pain management were increasingly registered in PROSPERO. ...
... Peritoneal lesions have been reported to be associated with dysmenorrhea [7]. Rigorous randomized controlled studies should be conducted to determine the effect of laparoscopic excision on patients with chronic pain and isolated peritoneal endometriosis [8,9]. ...
... В этом исследовании показана также относительная целесообразность применения габапентина при тазовой боли, обусловленная лучшим противоболевым действием и переносимостью в сравнении с амитриптилином [46]. В последующих рандомизированных исследованиях также были продемонстрированы эффективность габапентина в отношении ХТБ и положительное влияние препарата на эмоциональную сферу [47,48]. ...
... Помимо НПВП есть данные о применении различных нейромодуляторов (антидепрессантов, противосудорожных препаратов), которые в отличие от анальгетиков воздействуют на центральные механизмы боли. По данным исследований, эффективность этих групп препаратов не превосходит эффект плацебо, а их использование ограничивается развитием дозозависимых побочных эффектов [25]. Учитывая нейропатический характер боли, существует опыт применения психомоторных препаратов, антидепрессантов, нейромодуляторов, иглорефлексотерапии, демонстрирующих различную эффективность. ...
... As a chronic condition, endometriosis demands ongoing self-management of physical symptoms (eg, pain and sleep hygiene) [17], which represents a substantial psychological and emotional burden on the individual [18,19]. The need for self-management may also serve as a constant reminder of one's endometriosis diagnosis, exacerbating psychological distress [20]. ...