Katsumi Asano's research while affiliated with University of Tsukuba and other places

... Our data with isolated mitochondria suggest that one or more low-a¤nity cytosolic sites for ATP may control respiratory chain activity. However, an intracellular pH of 6.9 represents an acidic condition likely to occur in vivo only during exercise or ischemia [34]. Under such conditions, ATP levels fall below their resting concentrations, which in rat liver has been reported to be 6.2 mM [35]; thus, the IC 50 values obtained do not re£ect the intracellular ATP levels which would be present in vivo at pH 6.9. ...

... Previous studies have concluded that the physical fitness age was remarkably higher than the chronological age in individuals with low physical fitness (the frail older adults, for instance), while the physical fitness age was significantly F I G U R E 2 Changes of physical fitness age after 12 weeks intervention. *Means p < 0.05 lower than the chronological age in adults with high physical fitness (people with exercise habits, for example) (Lee et al., 1993;Nakagaichi et al., 2018). In light of this, in the present study we used the difference value between the physical fitness age and the chronological age to group participants into three classes, called high physical fitness (physical fitness age-chronological age <-3), low physical fitness (physical fitness age-chronological age >3), and normal physical fitness (-3 ≤ physical fitness agechronological age ≤3). ...

... Elmination of the CO 2 by lung ventilation, results in an excessive piration of CO 2 . Yano et al. (21) observed CO 2 expiration associated with an increase in the blood lactate level during incremental-l oad exercise a high work rate. This indicates that lactate kinetics can be estimated from CO 2 kinetics. ...

... Three studies (44--46) showed that longer durations elicit a greater increase in aerobic capacity, while three studies (47)(48)(49) reported no significant difference among groups performing different durations. The most recently cited study in the 1998 ACSM Position Stand (4) is a nonexperimental study that shows some association between duration of training and increases in aerobic capacity (50). Patients with coronary disease and/or hypertension, who were not randomly assigned to any specific exercise protocol, self-reported the duration and intensity of their calisthenics, stretching, cycling, walking, or aerobic dancing for 4 months. ...

... Tanaka et al. [1] defined vital age as an indicator constructed by applying a principal component model to evaluate biological age as an indicator of senescence; that is, to evaluate the level of senescence. Therefore, vital age is an indicator that comprehensively evaluates various health-related factors that determine levels of human health and senescence [2,3]. Hamasaki et al. [4] stated that since it is a scale that can be easily understood even by older adults, vital age can be an effective evaluation indicator in older adults attempting to improve their daily living habits and maintain their level of health. ...

... However, it is important to note that these human studies are not examining OS in the context of the brain or AD and this concept requires further research. Although the brain may be somewhat more protected against the OS produced by exercise compared to the periphery [105], evidence still suggests brain and cognitive degradation is, at least to some extent, associated with oxidative damage [106,107]. ...

... Doniesienia na temat zaburzeń snu towarzyszących pobytowi na dużych wysokościach znaleźć można także w badaniach, w których raportowano pogorszenie rytmu oddechowego w trakcie snu i zmiany w zakresie rytmu snu (Goldenberg et al., 1992;Mizuno et al., 2005). Obserwuje się powtarzalne, częste przebudzenia podczas snu (związane ze zmniejszoną saturacją krwi), nieregularny oddech oraz zwiększenie płytkości snu w fazie NREM (non-rapid eye movement) (Panjwani et al., 2007). ...

... [ DOI:10.52547/iau.32.4.347 ] [ DOR: 20.1001.1.10235922.1401.32.4.2.3 ] [ Downloaded from tmuj.iautmu.ac.ir on 2023-03-01 ] ...

... Hypoxia suggestively enhances the anaerobic metabolic rate during high-intensity exercises without influencing exercise performance (Calbet et al. 2003;McLellan et al. 1990McLellan et al. , 1993Ogawa et al. 2007;Ogura et al. 2006;Weyand et al. 1999). This implies that hypoxia would improve the impact of high-intensity exercise training on anaerobic energy systems, though its practicality is currently controversial (Fujimaki et al. 1999;Ogita and Tabata 1999;Truijens et al. 2003). Moreover, hypoxic/altitude training requires visiting high-altitude sites or installing a hypoxic chamber, which adds complications to the training. ...

... In this study, the VO 2max decreased 59% at 7000 m above sea level. On the other hand Takahashi et al. showed that elite climbers are characterized by their enhanced ventilatory response to HP rather than prominence in aerobic work capacity [26]. And when subjects return to sea level they did not appear to improve as Sutton et al. reported after Everest Operation II [13]. ...