Katharina Seidensticker's research while affiliated with University Hospital Würzburg and other places
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Publications (3)
Mittels Tissue Engineering hergestellte humane 3D in vitro-Testsysteme sind ein neuer Ansatz, um u.a. Erkrankungen der Atemwege zu simulieren und zu untersuchen. Obwohl gegen B. pertussis, den Erreger des Keuchhustens, Impfstoffe zur Verfügung stehen, nimmt die Erkrankungs-Inzidenz in den letzten Jahren deutlich zu. Da B. pertussis zu den obligat h...
3D respiratory tissue models have been generated using, for example, human primary airway epithelial cells (hAEC) or respective cell lines. To investigate ciliopathies, such as primary ciliary dyskinesia, the presence of functional kinocilia in vitro is an essential prerequisite. Since access to hAEC of healthy donors is limited, we aimed to identi...
Citations
... Micro uidics house a limited number of cells and limited cellular crosstalk, which prevent cell proliferation and the growth of tissue as in human lungs. Efforts have been made to overcome these problems such as the uses of transwells to establish larger scale 3D lung models [13]. These models are maintained in static culture conditions, which means that the dynamic nature of human lungs/body and disease are not mimicked appropriately and it is di cult to interrogate real time cellular responses in these systems [13]. ...
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