Karthikesh Varma Chintalapati’s scientific contributions

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Publications (3)


Figure 1: Dice scores on the test subset from the open dataset. The red dashed line denotes the median of the better-performing baseline method (i.e., DS6).
Figure 11: Dice scores on both the datasets combined. The red dashed line denotes the median of the better-performing baseline method (i.e., DS6).
Brief comparison of the methods
Published manuscripts and codes of some of the submitted methods
SMILE-UHURA Challenge -- Small Vessel Segmentation at Mesoscopic Scale from Ultra-High Resolution 7T Magnetic Resonance Angiograms
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November 2024

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40 Reads

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The human brain receives nutrients and oxygen through an intricate network of blood vessels. Pathology affecting small vessels, at the mesoscopic scale, represents a critical vulnerability within the cerebral blood supply and can lead to severe conditions, such as Cerebral Small Vessel Diseases. The advent of 7 Tesla MRI systems has enabled the acquisition of higher spatial resolution images, making it possible to visualise such vessels in the brain. However, the lack of publicly available annotated datasets has impeded the development of robust, machine learning-driven segmentation algorithms. To address this, the SMILE-UHURA challenge was organised. This challenge, held in conjunction with the ISBI 2023, in Cartagena de Indias, Colombia, aimed to provide a platform for researchers working on related topics. The SMILE-UHURA challenge addresses the gap in publicly available annotated datasets by providing an annotated dataset of Time-of-Flight angiography acquired with 7T MRI. This dataset was created through a combination of automated pre-segmentation and extensive manual refinement. In this manuscript, sixteen submitted methods and two baseline methods are compared both quantitatively and qualitatively on two different datasets: held-out test MRAs from the same dataset as the training data (with labels kept secret) and a separate 7T ToF MRA dataset where both input volumes and labels are kept secret. The results demonstrate that most of the submitted deep learning methods, trained on the provided training dataset, achieved reliable segmentation performance. Dice scores reached up to 0.838 ±\pm 0.066 and 0.716 ±\pm 0.125 on the respective datasets, with an average performance of up to 0.804 ±\pm 0.15.

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SPOCKMIP: Segmentation of Vessels in MRAs with Enhanced Continuity using Maximum Intensity Projection as Loss

July 2024

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19 Reads

Identification of vessel structures of different sizes in biomedical images is crucial in the diagnosis of many neurodegenerative diseases. However, the sparsity of good-quality annotations of such images makes the task of vessel segmentation challenging. Deep learning offers an efficient way to segment vessels of different sizes by learning their high-level feature representations and the spatial continuity of such features across dimensions. Semi-supervised patch-based approaches have been effective in identifying small vessels of one to two voxels in diameter. This study focuses on improving the segmentation quality by considering the spatial correlation of the features using the Maximum Intensity Projection~(MIP) as an additional loss criterion. Two methods are proposed with the incorporation of MIPs of label segmentation on the single~(z-axis) and multiple perceivable axes of the 3D volume. The proposed MIP-based methods produce segmentations with improved vessel continuity, which is evident in visual examinations of ROIs. Patch-based training is improved by introducing an additional loss term, MIP loss, to penalise the predicted discontinuity of vessels. A training set of 14 volumes is selected from the StudyForrest dataset comprising of 18 7-Tesla 3D Time-of-Flight~(ToF) Magnetic Resonance Angiography (MRA) images. The generalisation performance of the method is evaluated using the other unseen volumes in the dataset. It is observed that the proposed method with multi-axes MIP loss produces better quality segmentations with a median Dice of 80.245±0.12980.245 \pm 0.129. Also, the method with single-axis MIP loss produces segmentations with a median Dice of 79.749±0.10979.749 \pm 0.109. Furthermore, a visual comparison of the ROIs in the predicted segmentation reveals a significant improvement in the continuity of the vessels when MIP loss is incorporated into training.


Enhancing Vessel Continuity in Deep Learning based Segmentation using Maximum Intensity Projection as Loss

Vessel Segmentation with deep learning is a challenging task that involves not only learning high-level feature representations but also the spatial continuity of the features across dimensions. Semi-supervised patch-based approaches have been effective in identifying small vessels of 1-2 voxels in diameter but failed to maintain vessel continuity. This study focuses on improving the segmentation quality by considering the spatial correlation of the features using the maximum intensity projection (MIP) as an additional loss criterion. It was observed that the proposed method quantitatively improves the segmentation while also improving vessel continuity, as evident in the visual examinations of ROIs.