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June 2010
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71 Reads
ChemInform
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
April 2003
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365 Reads
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134 Citations
Journal of Natural Products
Three yellow pigments were isolated from a mycelial extract of the entomopathogenic fungus Paecilomyces militaris. With the aid of spectroscopic means, one compound was identified as a new pyridone alkaloid, militarinone D (1). The two other metabolites were characterized as two novel 3-acyl tetramic acids, militarinones B (2) and C (3). In contrast to the structurally related pyridone militarinone A (4), compounds 1-3 showed only negliable neuritogenic activity in PC-12 cells, whereas militarinone D (1) exhibited cytotoxicity. On the basis of a co-occurrence of 3-acyl tetramic acids and biogenetically related pyridone alkaloids in P. militaris, a revised biosynthetic pathway for pyridone alkaloids is proposed.
February 2002
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343 Reads
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101 Citations
Organic Letters
[structure: see text] A new pyridone alkaloid, militarinone A (1), was isolated by bioassay-guided fractionation from the mycelium of the entomogenous fungus Paecilomyces militaris. Its structure was established by extensive spectroscopic analysis. The compound features an unprecedented side chain and a 1,4-substituted cyclohexyl moiety not previously encountered in microbial metabolites. Militarinone A had a pronounced neurotrophic effect in PC-12 cells at 10 microM concentrations.
February 2002
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109 Reads
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25 Citations
Planta Medica
The culture medium of Beauveria amorpha Hohn. exhibited strong radical scavenging properties. Activity-directed fractionation assisted by a radical scavenging assay on TLC afforded two active compounds which were identified as 6-methyl-2,4-dihydroxyphenyl 4-O-methyl-beta-D-glucopyranoside (1) and (-)-terredionol (2). Compound 1 displays radical scavenging and lipid peroxidation inhibitory activity comparable to those of TroloxC, ascorbic acid or quercetin.
... Hz, J 22,23 = 14.7 Hz, J 23,24 = 10.7 Hz, J 24,25 = 15.2 Hz) (Schmidt et al. 2002) and by NOESY correlations between H-21/H-23 and H-23/H-25. The side chain features two methyl groups. ...
February 2002
Organic Letters
... The carbons at δ101.2, δ79.4, δ76.5, δ76.2, δ74.0, δ60.6 and δ60.0, and coupling relationships between the hydrogens connected to the carbons (Fig. 2) according well with a 4′-methoxyl-glucose moiety which existed commonly in metabolites of entomopathogenic fungus (Hu et al. 2002(Hu et al. , 2009). The chemical shifts and coupling relationships between aromatic carbons and hydrogens (Fig. 2) showed that the aglycone is a derivative of 1H-naphtho[2,3-c] pyran-1-ones which is consistent with the report (Ayer et al. 1991). ...
February 2002
Planta Medica
... including palbociclib [40], duvelisib [41], trametinib [42], ripretinib [43], and topotecan [44], contain the 2-pyridone moiety [45]. Among them, 4-hydroxypyridin-2(1H)-ones are particularly valuable in medicinal chemistry, drug discovery, and material science [46,47], found in various natural and synthetic compounds [48] with diverse biological activities [49][50][51][52][53][54][55][56]. Notable examples of 3-acyl-4-hydroxypyridin-2(1H)-one derivatives, such as Fischerin, Apiosporamide, Aspyridone, and Ilicicolin, exhibit neuroprotective, anticancer, cytotoxic, antifungal, and antibiotic properties, respectively [57][58][59][60]. ...
April 2003
Journal of Natural Products
