Karen Alfrey’s research while affiliated with Indiana University – Purdue University Indianapolis and other places

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Publications (8)


A Two-part Approach to the Hodgkin-Huxley Project: Challenging Students to Build Deterministic and Stochastic Models of Ion Channel Behavior
  • Article

March 2025

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7 Reads

Biomedical Engineering Education

Steven Higbee

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Sharon Miller

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Karen Alfrey

The Hodgkin-Huxley membrane conductance model has been featured in biomedical engineering (BME) curricula for decades. A typical BME assignment might require students to apply the relevant equations and parameters to model the generation of action potentials; however, there is opportunity for students to build and explore both deterministic and stochastic models of ion channel behavior. We have developed two projects that involve building mathematical Hodgkin-Huxley models, which are delivered in a required two-course sequence in the third year of our BME undergraduate curriculum. In the first project, students build and explore a deterministic Hodgkin-Huxley model, using numerical computing to solve differential equations. In the second project, students build stochastic models of individual potassium ion channels and whole cells by performing repeated simulations of ion channel states. Incorporating these applied, biomedically relevant projects offers many of the benefits of Project-based Learning (PBL), including building skills in critical thinking, problem solving, programming, and written communication.


Figure 1. Urban STEM Scholar Cohort Models.
Figure 3. Example scholar post from CN platform.
Gender Representation for University, Students Eligible for S-STEM, Scholars by Institution
First Generation Student Representation for University, Students Eligible for S-STEM, Scholars by Institution
Overall GPA Earned by Students Eligible for S-STEM vs. Scholars by Institution

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Board 420: Urban STEM Collaboratory: 5 Years of Lessons Learned
  • Conference Paper
  • Full-text available

June 2024

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36 Reads

Stephanie Ivey

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Aaron Robinson

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[...]

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Tony Chase
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An Initial Exploration of Engineering Student Perceptions of COVID's Impact on Connectedness, Learning, and STEM Identity

July 2021

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64 Reads

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2 Citations

In this paper, we seek to understand how the pandemic and remote learning have affected student perceptions of connectedness with their university, their campus, and their peers and classmates, so that we can more nearly meet their academic needs. By qualitatively analyzing interviews with engineering students about their experiences and perceptions of the pandemic and remote learning, we offer some initial observations of these students’ perceptions of the impact of the pandemic and remote learning.



Citations (5)


... Unlike a traditional recitation, the focus is on active, team-based problem-solving, with the peer leader providing guiding questions and hints on approaches to consider, rather than simply demonstrating the solution. PLTL has been shown to reduce DFW rates in large introductory Chemistry classes [16][17] -and, perhaps more importantly, to decrease performance gaps between demographic groups [18][19]. ...

Reference:

Board 420: Urban STEM Collaboratory: 5 Years of Lessons Learned
Fostering Success in Introductory Calculus through Peer-Led Team Learning (PLTL)
  • Citing Conference Paper
  • July 2023

... In this work, the leadership from three separate but similar programs operating at independent urban research universities, collaborate in a Track 3 NSF S-STEM funded project with the overall goal of not only increasing student success but in studying and extending their programs to better reach student populations in need. This collaboration team refers to itself as 'The Urban STEM Collaboratory', and consists of three unique intervention programs, one from each university, that support student success and have demonstrated positive student outcomes throughout the duration of the project, [3,4,5]. Although there are three separate intervention programs, the collaboration provides a platform on which each university can extend their support structures to further meet the needs of diverse urban populations, as well as to study and understand the needs of these populations more nearly. ...

Three Years of the Urban STEM Collaboratory

... To foster interaction among scholars across campuses and create a sense of belonging within the Urban STEM community, the program adopted CourseNetworking (CN), an academic social networking platform developed at IUPUI. Using social media to engage college students is not a novel approach and its positive impacts have been well-documented by numerous scholars [8][9][10][11][12]. The reason we chose to implement CN was its unique combination of social networking features, a gamification engine (Anar Seeds) that tracks and incentivizes participation, a digital badging system, and a robust ePortfolio tool. ...

An Initial Exploration of Engineering Student Perceptions of COVID's Impact on Connectedness, Learning, and STEM Identity

... In this work, the leadership from three separate but similar programs operating at independent urban research universities, collaborate in a Track 3 NSF S-STEM funded project with the overall goal of not only increasing student success but in studying and extending their programs to better reach student populations in need. This collaboration team refers to itself as 'The Urban STEM Collaboratory', and consists of three unique intervention programs, one from each university, that support student success and have demonstrated positive student outcomes throughout the duration of the project, [3,4,5]. Although there are three separate intervention programs, the collaboration provides a platform on which each university can extend their support structures to further meet the needs of diverse urban populations, as well as to study and understand the needs of these populations more nearly. ...

Launching the Urban STEM Collaboratory

... End of year wrap-up, reflection, and celebration meeting, and a preview of summer electronic mentoring and cohort assignments and facilitation activities. Table 1: Example schedule of annual CLEAR Scholars activities As previously reported [2], a key feature of CLEAR Scholars has been engagement with both campus and industry partners to provide programming and opportunities to our Scholars. Through Career Development Workshops, the Engineering and Technology Career Services Office provides both regular presentations about their services and one-on-one professional development including résumé review and mock interviews. ...

CLEAR Scholars in Engineering: Promoting Student Success through Cohort-Building and Industrial Engagement
  • Citing Conference Paper
  • June 2014