Kara J. Wyant's research while affiliated with University of Michigan and other places
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Publications (12)
OBJECTIVE
The effect of subthalamic nucleus (STN) deep brain stimulation (DBS) on urinary dysfunction and constipation in Parkinson’s disease (PD) is variable. This study aimed to identify potential surgical and nonsurgical variables predictive of these outcomes.
METHODS
The authors used the Movement Disorder Society–Unified Parkinson’s Disease Ra...
Introduction
Inconsistent effects of subthalamic deep brain stimulation (STN DBS) on pain, a common non-motor symptom of Parkinson's disease (PD), may be due to variations in active contact location relative to some pain-reducing locus of stimulation. This study models and compares the loci of maximal effect for pain reduction and motor improvement...
Digital health technologies can provide continuous monitoring and objective, real-world measures of Parkinson’s disease (PD), but have primarily been evaluated in small, single-site studies. In this 12-month, multicenter observational study, we evaluated whether a smartwatch and smartphone application could measure features of early PD. 82 individu...
Background and Objectives
Chronic health conditions are influenced by social determinants of health (SDH) including neighborhood-linked markers of affluence. We explored whether neighborhood socioeconomic factors differ in people with different types of clinical movement disorders (MDs).
Methods
We conducted a retrospective study of patients seen...
Introduction
The Social Provisions Scale (SPS) measures a person’s perceived social support. We evaluated the perceived social support in Parkinson’s disease (PD) patients before and after subthalamic nucleus (STN) deep brain stimulation (DBS) and its impact on clinical outcomes following DBS.
Methods
We analyzed 55 PD patients who underwent STN D...
Study objective:
Identifying individuals with isolated rapid eye movement sleep behavioral disorder (iRBD) is an important clinical research priority for future synucleinopathy trials. Nevertheless, little is known about the breadth of clinical settings where diagnoses of iRBD are initially made.
Methods:
We conducted a retrospective cohort stud...
Introduction
The effect of subthalamic nucleus deep brain stimulation (STN DBS) on urinary dysfunction and constipation in Parkinson’s disease (PD) is variable. This study aims to identify potential surgical and non-surgical variables predicting their outcome.
Methods
We used the Movement Disorder Society-Unified PD Rating Scale (MDS-UPDRS) Part I...
Introduction
Inconsistent effects of subthalamic deep brain stimulation (STN DBS) on pain, a common non-motor symptom of Parkinson’s disease (PD), may be due to variations in active contact location relative to a pain-reducing locus of stimulation.
Objective
To distinguish the loci of maximal effect for pain and motor improvement in the STN region...
The major clinical features, epidemiology, pathology, and pathophysiology of Parkinson disease are reviewed. Sleep disorders are common in Parkinson disease and significantly impair patient quality of life. Parkinson disease associated sleep disorders include multi-factorial insomnia, REM sleep behavior, restless legs syndrome, sleep disordered bre...
Background
Caregiver burden (CB) in Parkinson's disease (PD) does not improve in the short term after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS), despite motor improvement. This may be due to increased caregiver demands after surgery or the possibility that DBS unresponsive non-motor factors, such as executive dysfunction, con...
BACKGROUND
We know little about how well the goals and results of clinical trials in Parkinson disease (PD) reflect the priorities of patients and the broader PD community.
OBJECTIVES
We conducted a review of registered trials on clincialtrials.gov between 2007‐2016 to explore whether PD trials have moved closer to the therapeutic priority goals a...
Huntington’s disease (HD) is an autosomal dominantly inherited neurodegenerative disease characterized by progressive motor, behavioral, and cognitive decline, ending in death. Despite the discovery of the underlying genetic mutation more than 20 years ago, treatment remains focused on symptomatic management. Chorea, the most recognizable symptom,...
Citations
... The most promising trends in monitoring motor symptoms involve the use of wearable devices (wearables) to capture data from different sensors (i.e., inertial, bioelectrical) (14,16,17,20). Furthermore, recent trends in PD monitoring include the use of research-grade wrist devices (21)(22)(23), and smart technologies such as smartphones (SP) (15), and commodity smartwatches (SW) (24,25) to present promising cost-effective solutions for data collection and monitoring. ...
... Higher scores show greater caregiver burden. [19] The BSFC-s scale was classified as (0-4) points "none to mild", (5)(6)(7)(8)(9)(10)(11)(12)(13)(14) points "moderate", and (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) points "severe to very severe". [20] The caregivers were also asked to answer "how did caregiver burden change after DBS surgery?" question as positive, negative, or unchanged. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/826594495057924-1574086893941_Q64/Kelvin-Chou.jpg)
... Currently, no effective pharmacological treatment against cognitive decline in HD exists. 18 Therefore, no cognitive measurements will be performed. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/603734962864128-1520953040705_Q64/Andrew-Ridder.jpg)
