Kaori Yanase's scientific contributions
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Publications (2)
Studies on the effectiveness of substances such as drugs and cosmetics that act on the skin require structural evidence at the molecular level in the stratum corneum to clarify their interaction with intercellular lipid and soft keratin. For this purpose, when applying the substances to the stratum corneum X-ray diffraction experiment is one of the...
Objective:
Surfactants are major ingredients of body soaps and cleansers. Among them, harsh ones have been demonstrated to damage the skin. Stratum corneum (SC), the outermost barrier of skin layer, is rich in intercellular lipids. This lipid structure can be disrupted by surfactants, impairing the barrier function of the skin. Thus, we investigat...
Citations
... This fact indicates that a disordered lipid mixture that can emerge the LLS exists originally. The hydrocarbonchain packing structures are shown in Figure 3: (a) orthorhombic hydrocarbon-chain packing structure (ORTHO) [10,[14][15][16][17][18][19][20][21][22], (b) hexagonal hydrocarbon-chain packing structure (HEX) [17][18][19] and (c) disordered liquid state (LIQUID) [10,16,17]. The LLS spacing is about 13 nm [10][11][12]. ...
... Although these studies are investigating cleansing-induced skin damage, most studies to date have not focused on structures formed in the intercellular lipids of the SC, so the detailed underlying mechanism at the molecular level has not yet been established. Synchrotron X-ray diffraction was used to investigate structural change in the human SC resulting from sodium dodecyl sulfate (SDS) treatment, focusing on how SDS affects SC lipid structures such as the lamellar structures and the hydrocarbon-chain packing structures [65,66]. Here a special sample cell, called a "solution cell" developed by Hatta et al. [49], was used. ...
