Kana Tokumo's research while affiliated with Hiroshima University and other places

Publications (18)

Article
Full-text available
Critical flicker fusion frequency (CFF) is a short but sensitive method for evaluating optic nerve function. We measured CFF in patients with pituitary neuroendocrine tumors (Pit-NETs) to assess its usefulness. Data from 184 patients with nonfunctioning Pit-NETs, who had been treated with transsphenoidal surgery and had no medical history of eye di...
Article
Full-text available
Background Rho-kinase inhibitors can inhibit fibrosis after glaucoma surgery. This study aimed to evaluate the effect of rho-kinase inhibitor after needling procedure with mitomycin C for the failure of filtering bleb with trabeculectomy. Methods This retrospective single-center study examined the effects of rho-kinase inhibitor after the needling...
Preprint
Full-text available
Purpose To compare the efficacy of Ex-PRESS implantation (EXP) to trabeculectomy (TLE) with mitomycin C, for maintaining low target intraocular pressure (IOP) in patients with open-angle glaucoma. Methods Patients were randomly assigned to receive EXP or TLE. Surgical success was defined according to three target mean IOP ranges (5 mmHg ≤ IOP ≤ 18...
Preprint
Full-text available
Purpose: To compare the efficacy of Ex-PRESS implantation to trabeculectomy with mitomycin C, for maintaining low target intraocular pressure (IOP) in patients with open angle glaucoma. Materials and Methods: Patients were randomly assigned to receive Ex-PRESS implantation or trabeculectomy. Patients with IOP ≥ 15 mmHg were included in this study....
Preprint
Full-text available
Purpose Critical flicker fusion frequency (CFF) is a short but sensitive method for evaluating optic nerve function. We measured CFF in patients with pituitary neuroendocrine tumors (Pit-NETs) to assess its usefulness.Methods Data from 184 patients with nonfunctioning Pit-NETs, who had been treated with transsphenoidal surgery and had no medical hi...
Preprint
Objective Critical flicker fusion frequency (CFF) is a short but sensitive method for evaluating optic nerve function. We measured CFF in patients with pituitary neuroendocrine tumors (Pit-NETs) to assess its usefulness. Methods Data from 184 patients with nonfunctioning Pit-NETs, who had been treated with transsphenoidal surgery and had no medical...
Article
Purpose Carriers of functionally deficient mutations in the CYP39A1 gene have been recently reported to have a 2-fold increased risk of exfoliation syndrome (XFS). The aim of this study was to evaluate the risk of blindness and related clinical phenotypes of XFS patients carrying the loss-of-function CYP39A1 G204E mutation in comparison to XFS pati...
Article
Full-text available
PurposeTo compare surgical outcomes between patients who underwent Baerveldt glaucoma implantation versus trabeculectomy (TLE) for the treatment of neovascular glaucoma.Methods We performed a prospective, randomized, controlled clinical trial at Hiroshima University and Tsukazaki Hospital, Japan. Patients were randomized to Baerveldt glaucoma impla...
Article
Full-text available
Importance Exfoliation syndrome is a systemic disorder characterized by progressive accumulation of abnormal fibrillar protein aggregates manifesting clinically in the anterior chamber of the eye. This disorder is the most commonly known cause of glaucoma and a major cause of irreversible blindness. Objective To determine if exfoliation syndrome i...
Article
Full-text available
Purpose: To investigate the association between macular inner retinal layer thickness and macula visual field (VF) mean deviation as measured by the Humphrey Field Analyzer (HFA) or macular function as measured by focal macular electroretinograms (ERGs) in patients with glaucoma. Methods: The participants in this cross-sectional study were 71 patie...
Article
Aim In patients who underwent multiple intraocular surgeries, we evaluated determinants of decreased corneal endothelial cell density (CECD) after sulcus placement following Ahmed and Baerveldt drainage device surgery. Methods We retrospectively reviewed consecutive patients with glaucoma who underwent sulcus placement with an Ahmed glaucoma valve...
Article
Full-text available
To evaluate the efficacy and safety of ripasudil for treatment of secondary glaucoma, a historical cohort study was conducted at 18 centres in Japan. Adults (age ≥20 years) who needed additional IOP reduction and received topical 0.4% ripasudil between 2014 and 2018 due to three secondary glaucoma subtypes, including uveitic glaucoma (UG), exfoliat...
Article
Full-text available
Purpose: To compare performance of independently developed deep learning algorithms for detecting glaucoma from fundus photographs and to evaluate strategies for incorporating new data into models. Methods: Two fundus photograph datasets from the Diagnostic Innovations in Glaucoma Study/African Descent and Glaucoma Evaluation Study and Matsue Re...
Article
Precis: Corvis ST Tonometry and Ocular Response Analyzer measurements were conducted in primary open-angle glaucoma and normative subjects. Many parameters were significantly correlated, however, the strengths were weak to moderate. Purpose: Reichert Ocular Response Analyzer (ORA) parameters are derived from pressure information following the ap...
Article
Full-text available
Purposes To investigate associations between Corvis ST-measured corneal biomechanical parameters and glaucomatous optic nerve head (ONH) morphology. Methods In total, 118 eyes of 70 patients with open-angle glaucoma were examined in this retrospective cross-sectional study. We measured Heidelberg retina tomograph and Corvis ST values in all eyes....
Article
Full-text available
Aims Corvis ST (CST) yields biomechanical corrected IOP (bIOP) which is purported to be less dependent on biomechanical properties. In our accompanied paper, it was suggested that the repeatability of bIOP is high. The purpose of the current study was to assess the relationship between intraocular pressure (IOP) measured with CST and central cornea...
Article
Purpose To validate a deep residual learning algorithm to diagnose glaucoma from fundus photography using different fundus cameras at different institutes. Design Cross-sectional study. Participants A training dataset consisted of 1364 color fundus photographs with glaucomatous indications and 1768 color fundus photographs without glaucomatous fe...

Citations

... Trabeculectomy (Glaucoma filtration surgery) is currently the most common surgical treatment option for NVG. Trabeculectomy is indicated when medical and/or laser treatments do not provide sufficient IOP control or disease progression is observed [59]. The treatment involves creating a fistula that connects the anterior chamber of the eye with the subconjunctival space, thus creating an alternative drainage path of the eye fluid into the subconjunctiva. ...
... [10][11][12][13][14][15][16][17][18][19] More recently, an exome-wide association study identified disease associations with rare coding variants in the cytochrome P450 gene CYP39A1. 20 Additional attempts to understand PEX include targeted protein/proteomic analyses, which have identified more than 70 constituents of PEX material, and targeted gene expression studies, which have implicated multiple disordered biological processes in PEX. 2,[21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Despite advances in our understanding of the genetic, structural, and functional architecture of this disease, the mechanisms by which PEX results in its various ocular disease manifestations remain unclear. ...
... In particular, uveitic glaucoma was shown to be a risk factor for CECD reduction following trabeculectomy [5]. However, another study showed that uveitic glaucoma was not associated with CECD reduction after the sulcus placement of glaucoma 2 of 9 drainage devices [6]. Information regarding CECD reduction after the implantation of glaucoma drainage devices in patients with uveitis remains limited, and a further accumulation of data is needed, especially in the Asian population. ...
... muscarinic agonists [pilocarpine]; rho kinase inhibitors (e.g. ripasudil; Futakuchi et al., 2020) and netarsudil (Lin et al., 2018;Asrani et al., 2020)]; 3). first-line medications that mainly promote uveoslceral outflow of AQH from the anterior segment of the eye (via newly generated spaces between ciliary muscle and the sclera), with some conventional outflow inducing actions (Toris et al., 2008) (e.g. ...
... The work by Lo et al. demonstrated the successful implementation of the federated framework to train more generalizable aggregated models of retinal vessel segmentation and diabetic retinopathy classification using OCT data from three different institutions and different OCT machines with distinctive distributions of disease severity (78). With regard to glaucoma, the work by Christopher et al. exemplified the successful training of federated models for glaucoma detection using data from two institutions containing distinctive racial populations (79). For accelerating reverse translation into basic science, future studies are envisioned that involve collaborative efforts and openness in building shared data sources of preclinical imaging, biochemical, and behavioral modalities in healthy animals across species, age, and gender, as well as experimental high-tension and normal-tension glaucoma disease models for establishing robust baselines and predicting neurobehavioral changes for further research. ...
... 104 This finding is not universal, however, as several groups have reported either that patients with primary open-angle glaucoma have more deformable corneas than healthy control patients, 105 or that there is no difference in corneal stiffness between the two groups. [106][107][108][109] The possible globe-softening effects of topical prostaglandin analogues and/or the Corvis-ST-generated corneal stiffness parameters chosen to represent corneal stiffness may be the sources of these disparate reports of corneal stiffness in glaucoma. ...
... They concluded that eyes with a superior-dominant rim volume reduction of ONH were associated with small deformations and the cornea's slow recovery. (48) Jung et al. found a correlation between Corneal de ection amplitude and glaucoma progression. Eyes with greater corneal de ection amplitude showed a faster VF progression rate in patients with POAG. ...
... 15 The bIOP(v1) was assessed in a number of later studies and was shown to be successful in reducing correlation with stiffness parameters, most notably CCT and age, as well as reducing the effect of the biomechanical change caused by refractive surgeries on IOP measurements. [16][17][18] In addition, it was shown to be reliable when compared to monometric IOP values. 19 However, despite the success of the bIOP(v1), there is still a need to reduce its dependence on corneal biomechanics further, especially given that the bIOP(v1) has become an integral component of other Corvis ST parameters such as the Stiffness Parameter (SP; strongly associated with overall corneal stiffness) and the Stress Strain Index (SSI; a measure of corneal material stiffness); it is also part of SP at Aplanation 1 in the Corvis Biomechanical Index (CBI; used in early diagnosis of keratoconus). ...
... The two models are specifically used for medical image classification, segmentation, and feature extraction 46,47 . These two models exhibited comparatively better performance in the literature than other DL models on OCT images for glaucoma detection 11,13,14,47 . ResNet18 and VGG16 consist of total 71 and 41 layers, respectively, and both require 224 × 224pixel size images for the input layer. ...