Kamilla Winding's research while affiliated with IT University of Copenhagen and other places

Publications (14)

Article
Full-text available
Type 2 diabetes is associated with microvascular dysfunction, but little is known about how capillary ultrastructure is affected by exercise training. To investigate the effect of two types of exercise training on skeletal muscle capillary ultrastructure and capillarization in individuals with type 2 diabetes, 21 individuals with type 2 diabetes we...
Article
This study compared the effects of moderate-intensity endurance training and high-intensity interval training on fiber type-specific subcellular volumetric content and morphology of lipid droplets and mitochondria in skeletal muscles of type 2 diabetic patients. Sixteen sedentary type 2 diabetic patients (57{plus minus}7 years old) were randomized...
Article
AIM To evaluate if high-intensity interval training (HIIT) with a lower time commitment can be equally effective as endurance training (END) on glycemic control, physical fitness and body composition in individuals with type 2 diabetes. MATERIALS AND METHODS Twenty-nine individuals with type 2 diabetes were allocated to control (CON; no training),...
Article
Full-text available
Aim: Physical activity after prostate cancer diagnosis has been shown to reduce the risk of disease progression. Here, we aimed to evaluate the effect of a 2-year home-based endurance training intervention on body composition, biomarkers levels, and prostate-specific antigen (PSA) doubling time as a surrogate end-point for progressing disease. Me...
Article
We determined the effects of exercise on pancreatic endocrine responses to metabolic stimuli in type 2 diabetic (T2D) subjects and examined the influence of the diabetic status. Fourteen subjects underwent a hyperglycaemic clamp with GLP-1 infusion and arginine injection, the morning after a one-hour walk or no exercise. Subjects were stratified by...
Article
Aims/hypothesis By use of a parallel and partly crossover randomised, controlled trial design we sought to elucidate the underlying mechanisms behind the advantageous effects of interval walking training (IWT) compared with continuous walking training (CWT) on glycaemic control in individuals with type 2 diabetes. We hypothesised that IWT, more th...
Article
Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. The present study investigates if endurance training improves insulin sensitivity and body composition in ADT-treated prostate cancer patients. Nine men undergoing ADT for prostate cancer and 10 healthy men wi...
Article
Full-text available
Age dependent decline in skeletal muscle function leads to impaired metabolic flexibility in elderly individuals. Physical activity and testosterone treatment have proven efficient strategies for delaying this condition. However, a common molecular pathway has not been identified. Muscle specific miRNAs (myomiRs) regulate metabolic pathways in skel...
Article
Context: Investigating the impact of hyperglycemia on pancreatic endocrine function promotes our understanding of the pathophysiology of hyperglycemia-related disease. Objective: The objective of the study was to test the hypothesis that experimental hyperglycemia impairs insulin and glucagon secretion. Design: A randomized, crossover in healt...
Article
Ageing is associated with an impaired ability to modulate sympathetic vasoconstrictor activity (functional sympatholysis) and a reduced exercise hypaeremia. The purpose of this study was to investigate whether a physically active lifestyle can offset the impaired functional sympatholysis and exercise hyperaemia in the leg and whether ATP signaling...
Article
Full-text available
OBJECTIVEdTo evaluate the feasibility of free-living walking training in type 2 diabetes patients, and to investigate the effects of interval-walking training versus continuous-walking training upon physical fitness, body composition, and glycemic control. RESEARCH DESIGN AND METHOD SdSubjects with type 2 diabetes were randomized to a control (n =...

Citations

... Studies evaluating VEGF in humans are limited. Mortensen et al. (2019) found no change in its levels after HIIT treatment. They also found no difference in capillarization, capillary structure, and exercise hyperemia between moderate-intensity endurance training and LIIT 61 ; however, our study showed ments at three different timepoints of the effects of HIIT on VEGF. ...
... On the contrary, it is already known that regular physical exercise leads to the formation of new capillaries (Wagner et al., 2016). Angiogenesis is a multistage process controlled by a variety of growth factors and other angiogenic molecules (Mortensen et al., 2019), such as VEGF, the most potent mitogen in endothelial cells (Ferrara et al., 2003), and NO, the most potent vasodilator (Cooke and Dzau, 1997). The NO production by specific NO synthase in erythrocytes, ( Jubelin and Gierman, 1996;Kang et al., 2001) may have a large impact on the overall NO availability, production, and angiogenesis (Kleinbongard et al., 2006) owing to the sheer number of erythrocytes in the body. ...
... However, this increase was not observed in obese men submitted to exercise [97]. Moreover, exercise decreased [98,99] or did not modify LD size [96]. However, this discrepancy could be due to the subcellular localization of the LD that were analyzed. ...
... One study was able to show that high-intensity physical activity can positively influence GV in people with T2D. However, this did not reduce the mean CGM glucose level [44]. Furthermore, this study showed that fluctuations in glucose levels may be more harmful than a constant high and stable mean glucose level [44]. ...
... To date, there have only been few studies reporting the effects of exercise training on tumour biology in a human setting [1,[15][16][17]. One of the first explorative studies individual data points. ...
... walk) under similar clamping conditions was associated with increased insulin secretion in response to infusion of GLP-1 [40]. Yet, the mechanisms involved in beta-cell adaptations to acute and long-term exercise may differ. ...
... Of these, 12 studies [43,44,46,47,49,51,52,55,56,58,63,64] presented the results of oxygen consumption in VO 2max , being 10 studies [43,44,46,47,49,51,52,55,56,58] with the unit of measure in mL/kg·min, one study [64] in mL/min and another study in L/min [63]. The last two studies were transformed to mL/kg·min using the body weight presented by each of the studies. ...
... Thus, the emergence of time-efficient modes of exercise training, such as high intensity interval training (HIIT) featuring short near-maximal to maximal activity periods interspersed by shorter low-intensity activity periods or passive rest, is an alternative to traditional exercise training programs . Despite the reduction in total training duration, HIIT improves blood glucose, insulin sensitivity, and GLUT-4 expression in skeletal muscles (Little et al., 2011a;Karstoft et al., 2014). ...
... The abundant miR-133a in skeletal muscle plays an important role in mitochondrial function and the aging process of skeletal muscle. Moreover, a sex difference in miR-133a and miR-133b content in the quiescence state was observed [100]. These results suggest that there may be sex differences in miRNA regulation. ...
... Patients included received different treatment modalities across and within the 33 included trials. Fifteen trials reported primarily patients on ADT treatment [20,[22][23][24][25]27,30,38,40,42,[44][45][46]48,49], six trials reported a combination of ADT and radiotherapy [28,29,32,33,39,43] and one trial reported radiotherapy alone [37]. Others reported previous prostatectomy [35,41], and previous surgery, radiotherapy or a combination of those [31]. ...