February 2025
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10 Reads
Journal of Environmental Chemical Engineering
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February 2025
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10 Reads
Journal of Environmental Chemical Engineering
February 2025
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2 Reads
Microchemical Journal
November 2024
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3 Reads
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2 Citations
Talanta
November 2024
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12 Reads
International Journal of Biological Macromolecules
August 2024
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56 Reads
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1 Citation
Microchimica Acta
Cocaine is one of the most abused illicit drugs, and its abuse damages the central nervous system and can even lead directly to death. Therefore, the development of simple, rapid and highly sensitive detection methods is crucial for the prevention and control of drug abuse, traffic accidents and crime. In this work, an electrochemical aptamer-based (EAB) sensor based on the low-temperature enhancement effect was developed for the direct determination of cocaine in bio-samples. The signal gain of the sensor at 10 °C was greatly improved compared to room temperature, owing to the improved affinity between the aptamer and the target. Additionally, the electroactive area of the gold electrode used to fabricate the EAB sensor was increased 20 times by a simple electrochemical roughening method. The porous electrode possesses more efficient electron transfer and better antifouling properties after roughening. These improvements enabled the sensor to achieve rapid detection of cocaine in complex bio-samples. The low detection limits (LOD) of cocaine in undiluted urine, 50% serum and 50% saliva were 70 nM, 30 nM and 10 nM, respectively, which are below the concentration threshold in drugged driving screening. The aptasensor was simple to construct and reusable, which offers potential for drugged driving screening in the real world.
August 2024
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16 Reads
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1 Citation
Biosensors and Bioelectronics
August 2024
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23 Reads
Journal of Electroanalytical Chemistry
June 2024
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43 Reads
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1 Citation
Sensors and Actuators B Chemical
March 2024
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29 Reads
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6 Citations
Sensors and Actuators B Chemical
February 2024
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21 Reads
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4 Citations
Analytica Chimica Acta
... Lateral-flow immunoassay using electrochemical transducers is a rapid method for the identification of THC which is able to detect it in an analysis time of 6 min with a detection limit of 1.3 ng/mL [97]. Another electrochemical method using an aptasensor for the detection of THC in saliva showed a one-minute identification [98] with a detection limit of 5 nM in serum, 5 nM in urine and 10 nM in 50% diluted saliva [99]. Despite the fact that these methods are very rapid and have a nanomolar detection limit, they cannot exclude false positive reactions during routine determinations, especially because they do not identify metabolites in the same run. ...
February 2024
Analytica Chimica Acta
... Following this, the response for ketamine detection was observed at each concentration using CV and LSV. The aptamer-immobilized electrodes were employed to detect ketamine at various temperatures (15,25,35,45,55, 65 • C) and times (5 to 35 s), and the best cyclic response was observed. The target was detected using the electrodes that had been immobilized with the aptamer. ...
April 2023
Sensors and Actuators B Chemical
... Changing the concentration of redox-label modified aptamers is a key point in controlling the spacing of the aptamer [31]. Excessively high aptamer densities result in spatial site-blocking, which prevents target binding, while much lower aptamer densities make the signal undetectable [32]. Therefore, the aptamer concentrations at planar and porous electrodes were optimized (Fig. 2). ...
December 2021
Analytical Chemistry
... Cellulose derivative continued to be a topic of research interest according to its abundant, easy handling, biodegradation [1][2][3]. Carboxymethyl cellulose which is termed CMC, is one of famous examples of cellulose derivatives. Even it is considered as the most used cellulose derivatives in the industry. ...
December 2018
Journal of Electroanalytical Chemistry
... In lignocellulose, this leads to a blueshift (Fig. 5c) and a decrease (Fig. 3a) in emission, as observed in the present study. 6. Phosphorescence was not examined in this study, but reported for cellulose by Grönroos et al. (2018). ...
June 2018
... More recently, blends of polystyrene (PS) and PCL as a binder were investigated by our group and found to have much lower capacitance and faster electron transfer kinetics than PCL TPEs due to their surface morphology and enhanced edge plane characteristic [47] . SEM and electrochemistry data indicate PS TPE surfaces have lower roughness and more graphitic edge-plane rich features than PCL TPEs likely owing to aromatic nature of PS which allows interactions to the graphite surfaces through ππ interactions [48] . In addition, PS-based TPEs have been demonstrated to have enhanced electron transfer kinetics compared to previously reported PS electrodes [49][50][51][52] . ...
June 2018
Electrochimica Acta
... Insulating polymer material surrounds the carbon black particles and enables electrons to be transported through the thin composite layer with very low IR-loss, and finally hot electrons to be emitted at the electrode/solution interface. The main advantage of these novel electrodes over traditional insulating thin-film covered electrodes is their insensitivity to composite layer thickness and composition of the film [9,15,21,22]. Compared to thin insulating film-coated electrode materials, such as aluminum or silicon, composite electrodes are found to have a more stable and reproducible HECL output in a wider pH range, and most importantly, without considerable background emission [15,23,24]. ...
February 2018
Electrochimica Acta
... Solvated electrons, and hydrated electrons in water, are the chemist's perfect reducing agent in many ways. Recently, we made efforts to develop low-cost replacements [6,7] for chemically quite non-resistant oxide-coated aluminium electrodes [8][9][10] and typically a bit too expensive oxide-coated silicon electrodes [7,8] for hot electron injection into fully aqueous electrolyte solutions [1][2][3][4][5]. ...
July 2017
Analytica Chimica Acta
... These added co-reactants generate oxidizing radicals upon one-electron reduction (e.g., peroxodisulphate, peroxodiphosphate or hydrogen peroxide) or in the case of azide, upon one-electron oxidation. Thus, both extremely strong oxidants and reductants are produced, and normally one-electron redox reactions not obtainable occur and the excitation of several types of label compounds are enabled [4,9]. There are two major excitation routes: one usually being clearly dominant, and sometimes both excitation routes are almost equally significant, mostly depending on the lifetime and the redox properties of all the radical species involved in the system in aqueous solution. ...
May 2017
Electrochimica Acta
... HECL has been studied with several electrode materials (e.g. Al/Al 2 O 3 , Si/SiO 2 , C/ C x O 1−x and Ta/Ta 2 O 5 ) [6] [9,20,21] and different electrode types such as integrated electrodes [12], microelectrodes with very sharp tips and minimal electrode surface areas [22] and metal/insulator/metal electrodes (e.g. Ta/Ta 2 O 5 /Pt) [23] and lately novel conductor particlesdoped composite electrodes. ...
October 2016
Journal of Electroanalytical Chemistry