Kaifang Zou's research while affiliated with Union Hospital Terre Haute and other places

Publications (14)

Article
Background and purpose The maintenance of intestinal mucosal barrier function plays an important role in hepatic steatosis. Increasing evidence has shown that resolvin D1 (RVD1) exerts a potential effect on hepatic steatosis. The aims of this study were to explore the mechanisms of RVD1 on hepatic steatosis based on the gut-liver axis and intestina...
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Background Intestinal fibrosis is the most common complication of inflammatory bowel disease; nevertheless, specific therapies are still unavailable. Resolvin D1 (RvD1), a typical endogenous ω-3 fatty acid-derived lipid mediator, has attracted wide attention due to its remarkable anti-fibrosis effects. However, the efficacy and mechanisms of RvD1 i...
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Background Psychosocial factors are seemed as important causes of functional gastrointestinal disorders (FGIDs). However, the role of stress in FGIDs in high school students under the pressure of college entrance examination is largely unknown. The aim of this study is to investigate the association between the stress and FGIDs in high school gradu...
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Objectives: The COVID-19 epidemic triggered by coronavirus SARS-CoV-2 is rapidly spreading around the globe. This study is aimed at finding out the suspected or confirmed SARS-CoV-2 infection in patients with inflammatory bowel disease (IBD) in Hubei province, China. We also investigated symptoms, medications, life quality, and psychological issue...
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Background: Clinical data suggest that enteral nutrition (EN) effectively decreases disease activity and maintains remission in patients with inflammatory bowel disease (IBD). However, the modulatory effects of EN on the intestinal mucosal immune system remain unclear. Aims: This study first aimed at comparing the therapeutic effects of three EN...
Article
Estrogen receptor (ER) β activation has anti-inflammatory activity. However, its effect on the development of inflammatory bowel disease (IBD) and the underlying mechanism have not been clarified. This study aimed to assess the clinical value of ERβ+CD4+ T cells in IBD patients and examine the anti-inflammatory role of ERβ activation in dextran sul...
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Background: Mesalamine is a first-line drug in the treatment of inflammatory bowel diseases, while its intolerance occasionally occurs in clinical practice. Most of adverse reactions are due to the active components, which may lead to step-up treatment, but excipients are sometimes regarded as the chief culprit and can be resolved by transferring...
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Rationale Inferior mesenteric arteriovenous fistula (IMAVF) is a rare condition principally characterized by portal hypertension and ischemic bowel disease. Up to now, only 30 cases have been reported. Presented here is an IMAVF patient with nonpulsatile abdominal mass as the main manifestation. Patient concerns A 62-year-old Chinese male who comp...
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Background: Tight crosstalk between the circadian and immune systems has been reported in several inflammatory diseases. We hypothesized that circadian timekeeping was perturbed in inflammatory bowel disease (IBD), and that the bidirectional regulation of circadian disturbance and inflammation may be involved in the pathogenesis of IBD. Methods:...
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Faecal calprotectin and faecal occult blood test (FOBT) were widely used in the diagnosis and assessment of intestinal inflammation in inflammatory bowel disease (IBD). Recently we identified an excellent new biomarker B cell-activating factor (BAFF) for IBD. Here in this study we compared the efficacy of faecal BAFF, calprotectin and FOBT to find...
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Background B cell-activating factor (BAFF) has been proposed to be a regulator of B cell and T cell immune responses and be associated with inflammatory processes in autoimmunity and B cell malignancies. No study has reported the role of BAFF in inflammatory bowel disease (IBD). Aims The purpose of this study was to investigate expression and conce...
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Background Cronkhite-Canada Syndrome (CCS) is a rare non-inherited disease characterized by gastrointestinal polyposis and ectodermal abnormalities, the estimated incidence is about one per million. Recognizing and curing the disorder face great challenge. Case presentation This report refers to a Chinese 52 year old man with gastrointestinal symp...

Citations

... The results of a study evaluating the impact of epidemiological measures on social distancing and isolation at home showed that symptoms of anxiety and depression, as well as QoL impairment, were found in 20-30% of patients [15]. Other studies that quantified the effects of COVID-19 epidemiological measures on the health of patients with chronic conditions showed that QoL was unaffected by COVID-19 [16,17]. Based on these premises, the present study aims to assess the impact of the COVID-19 pandemic on the QoL of patients with IBD. ...
... Sulfur-containing amino acids such as methionine, taurine, homocysteine, and cysteine are abundant in plants and animals with numerous biological activities [174]. They exhibit significant antioxidant and anti-inflammatory effects [174,175]. Sulfurcontaining amino acids are metabolically interconnected, therefore a clear discrimination of their actual contribution to a biological effect cannot always be achieved. For instance, homocysteine is a product of the methionine cycle. ...
... TIGIT was demonstrated as a distinct marker for activated Tregs, and TIGIT expression on FoxP3 + Tregs was confirmed to enhance the suppressive effects of FoxP3 + Tregs (8,56). In a dextran sulfate sodium (DSS)-induced chronic colitis mouse model, significantly lower frequencies of TIGIT + Tregs were found in spleen, mesenteric lymph node (MLN), lamina propria mononuclear cells (LPMC), and colonic intraepithelial lymphocytes (IEL) compared to the control groups (92). Moreover, treatment with ERb agonist ERB041 could significantly restore the frequency of TIGIT + Tregs and alleviate DSS-induced chronic colitis and inflammation in mouse models, implicating the potential roles of TIGIT expressed on Tregs during the development of chronic colitis (92). ...
... In comparison, an infection rate of 13-15% has been reported previously in patients treated with immunosuppressant after ICI therapy, while only 2% in those who did not receive additional immunosuppressive therapy (Favara et al. 2020;Del Castillo et al. 2016) Furthermore, Wang et al. reported a rate of infection in patients treated with steroids for greater than 30 days for ICI diarrhea and colitis to be approximately 40% vs. 26% for those on steroids for less than 30 days . These findings highlight the importance of minimizing immunosuppressive therapies when possible with a particular consideration to the length of steroids use, especially among those patients with no objective histologic colitis who generally had mild disease course (Wang et al. 2018b) Furthermore, mesalamine and cholestyramine are generally well tolerated; patients may rarely experience headache, fever, rash, nausea, or vomiting, flatulence, constipation, with rare reports of hepatoxicity, pancreatitis, and interstitial nephritis related to mesalamine therapy (Rubin et al. 2019;Xie et al. 2019;Barkun et al. 2013). In the present study, there were no significant adverse events related to mesalamine and cholestyramine; however, the small cohort of cases limits these findings. ...
... Angiography is useful for diagnosis of the IMAVF as it provides specific findings such as influent artery dilatation, abnormal blood vessel gathering, and early venous return. Recently, it has been shown that minimally invasive examinations including MR angiography and three-or four-dimensional CT angiography are also effective for diagnosis of IMAVF [18][19][20] . Treatment for the IMAVF includes surgery, IR, or both [13,14] . ...
... In IBD, it has been suggested that circadian genes are reduced in intestinal biopsies of patients with UC and CD compared to healthy controls and that further genetic differences can be identified between biopsy samples of active and inactive disease [98,99]. Dysregulation of clock gene expression is thought to lead to circadian disruption, altered cytokine secretion, and to potentially trigger chronic inflammatory conditions. ...
... Его можно обнаружить в различных биологических жидкостях, таких как сыворотки крови, слюна и моча, кал [18]. Концентрация ФК в кале пропорциональна миграции нейтрофилов в желудочно-кишечный тракт, и, таким образом, кальпротектин является наиболее широко измеряемым маркером в кале [18,19]. В клинической практике измерение ФК используется для дифференциации функциональных расстройств кишечника, главным образом синдрома раздраженного кишечника, и воспалительных заболеваний кишечника [18]. ...
... Increasing studies hint BAFF may have an important regulatory role in inflammatory diseases, namely, systemic lupus erythematosus (SLE) (3), primary Sjögrens syndrome (pSS) (4), atherosclerosis (5), chronic obstructive pulmonary disease (COPD) (6), and IBD (7). Our previous study found that BAFF, a new biomarker for IBD, was strongly associated with IBD-related intestinal inflammation and that serum BAFF levels in patients with ulcerative colitis were strongly correlated with Mayo score and TNF-a presented all strong positive correlations (8). Previously, we detected increased expression of BAFF in serum and colon in IBD patients, with sensitivity, specificity and AUC of 88%, 100% and 0.936 in UC patients compared to irritable bowel syndrome (IBS) patients or healthy controls, respectively (8). ...
... Multiple biopsies from different sites of the gastrointestinal tract are critical for diagnosing CCS. The finding of diffuse mucosal edema in different sites of gastrointestinal tract is very important because there have been a few reported cases with absence of polyposis [3,5,21,24]. The polyps in CCS includes hyperplastic polyp, tubular adenomas, juvenile/hamartomatous polyp and inflammatory polyp. ...