Kaarin Lund’s research while affiliated with NorthShore University HealthSystem and other places

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Progestins inhibit calcitriol-induced CYP24A1 and synergistically inhibit ovarian cancer cell viability: An opportunity for chemoprevention

Article

April 2016

74 Reads

30 Citations

Gynecologic Oncology

[...]

... Progestins also inhibit calcitriol (CAL)-induced CYP24A1 expression through PR-dependent mechanisms, thereby prolonging CAL activity. This combination therapy of progestins and vitamin D warrants further investigation as a potential strategy to inhibit ovarian carcinogenesis (167). Additionally, another study highlighted the critical role of P4 and the presence of PRs in reducing disease progression in endometrioid ovarian carcinoma (168). ...
Reference:
Nuclear receptors in ovarian cancer: changing paradigms in cancer therapeutics