Kaarin Lund's research while affiliated with NorthShore University HealthSystem and other places
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Citations
... In those studies where OC cell models were characterized and well controlled, exposure of OC cell lines to progestins for 3 to 5 days resulted in decreased cell viability and cell numbers supporting the anti-proliferative actions of this hormone in OC cell models (159,160). Progesterone also appeared to induce apoptosis, with increased caspase-3 activation after 72 hours of treatment and increased p53 and BAX protein and decreased BCL-2 after 24 hours (159). Studies from the Lange lab revealed that signaling through nPRB, in the presence of the nuclear receptor specific progestin R5020 (10 nM, 96 hours), can induce senescence in ES2 and PEO4 advanced OC cell lines via Forkhead-box transcription factor 1 (FOXO1)-dependent upregulation of p21 and p16 (95). ...
