K.M. Shafeekh's research while affiliated with Jawaharlal Nehru Centre for Advanced Scientific Research and other places

Publications (10)

Article
Colloidal microcapsules based on supramolecular architectures feature attractive properties and offer new opportunities in diverse areas, like delivery, sensing, and catalysis. Herein, we report a new strategy to fabricate colloidal membrane and stimuli responsive microcapsules by utilizing cucurbit[7]uril mediated interfacial host-guest molecular...
Article
Background: Photodynamic therapy (PDT) has clinical approval for use as a minimally invasive therapeutic procedure that is able to exert selective cytotoxic activity toward malignant cells. The dye selected for our study, symmetrical diiodinated squaraine, is one of the newly developed photosensitizers. The study is designed to determine the effic...
Article
Photodynamic therapy (PDT) is emerging as a promising non-invasive treatment for cancers. It involves three key components; a photosensitizer, light and tissue oxygen. Even though several photosensitizers have been investigated for their use in PDT, they have several disadvantages and hence the search for more effective sensitizers has become impor...
Article
Here we report the synthesis, photophysical properties and photodynamic effects in DLA live cells of three water soluble squaraine dyes, viz. bisbenzothiazolium squaraine dyes SQMI and SQDI with iodine in one and both benzothiazolium units respectively and an unsymmetrical squaraine dye ASQI containing iodinated benzothiazolium and aniline substitu...
Article
A joint experimental and theoretical study is presented of two asymmetric squaraine dyes and of their parent symmetric dyes. The definition of reliable essential state models for asymmetric squaraines sheds light on the intriguing spectroscopic behavior of this class of molecules, showing inverted and normal solvatochromism in absorption and emissi...
Article
A novel class of sulphonate group containing unsymmetrical squaraine dyes has been synthesized. These dyes show a selective and sensitive affinity towards Hg2+ in methanol and are practically insensitive to most other environmentally and biologically relevant metal ions. Isothermal titration calorimetric (ITC) studies and High Resolution Mass Spect...
Article
Full-text available
The essential oil composition of Cinnamomum citriodorum leaves and petioles was determined by gas chromatography (GC) and GC-mass spectrometry (GC-MS) analysis. Leaf and petioles yielded 0.11% and 0.42% essential oil respectively. In leaf oil, twenty-seven constituents representing 97.2% of the oil were identified. Major components of the oil were...
Article
The constituents of the essential oils of leaf, petiole, shoot and terminal shoot of Cinnamomum malabatrum were determined by GC and GC–MS. Thirty-nine compounds, constituting 95% of the oil, were identified in the leaves. Major constituents of the leaf oil were (E)-caryophyllene (28.6%), (E)-cinnamyl acetate (15.1%), bicyclogermacrene (14.4%) and...
Chapter
This book (24 chapters) covers the chemistry (chemical composition and structure) of the following spice plants and their products, and provides brief information on the morphology, and postharvest management (storage, packaging and grading) of these crops: black pepper ( Piper nigrum ), small cardamom ( Elettaria cardamomum ), large cardamom ( Amo...

Citations

... This effect is more significant when using NPs, where DE is comparable to thermal energy. As a result, thermal fluctuations can easily weaken the confinement of NPs at the interface and lead to the eventual detachment of NPs from the interface [38]. ...
... In the same year, Soumya et al. [90] reported a study that examined the in vivo effects of an N-butyl sultone benzothiazole-based squaraine (3), which in vitro photobiological activity had been previously evaluated; the results showed the promise of this molecule compared with other monoiodinated analogs [91,92]. After sacrificing Swiss albino mice with skin tumors, in which squaraine was administered and the tumor region irradiated, biochemical studies were performed on skin flaps. ...
... Leguminosae), highly esteemed by both east and west, has a long history of being used as a medicinal herb and has been regarded as a treatment for just about every ailment known to man [1]. Right from early times, it has been extensively used in both Indian Ayurveda and Unani systems of medicines as well as traditional Chinese medicines for treatment of epilepsy, paralysis, gout, dropsy, chronic cough, diabetes, piles sinus, and lung congestion, inflammation, infection mitigation, hair treatment, breast enhancement, and aphrodisiac effects [2][3][4]. The crop species has also long been used as a galactagogue to promote lactation in weaning mothers as well as for its ability to treat wounds and sore muscles [2,5]. ...
... The inner bark of the plant is used as a medicine. Citronellol, the main component of C. citriodorum essential oil, has been shown to inhibit NO and PGE2 production in a dose-dependent fashion via inhibition of iNOS enzymatic activity [68,69]. Furthermore, citronellal was reported to activate peroxisome proliferator-activated receptors α and γ (PPAR-α and -γ) in cell culture assays [70]. ...
... In the same year, Soumya et al. [90] reported a study that examined the in vivo effects of an N-butyl sultone benzothiazole-based squaraine (3), which in vitro photobiological activity had been previously evaluated; the results showed the promise of this molecule compared with other monoiodinated analogs [91,92]. After sacrificing Swiss albino mice with skin tumors, in which squaraine was administered and the tumor region irradiated, biochemical studies were performed on skin flaps. ...
... We suspect that Br-Sq-C12 molecules in the QS_Sq_200 suffer from aggregation due to the higher concentration compared to QS_Sq_160, leading to a decrease of the squaraine photochemical properties and, in consequence, a lower PDT efficiency. Of note, the concentration of free squaraine usually employed for PDT studies ranges from 1 to 100 μM [49,67,68]. Here, we show that the use of a nanocarrier system allows using much lower concentrations of photosensitizer (up to 10-1000 times lower). ...
... Their absorption bands can be tuned by varying the constituent aromatic or heteroaromatic groups. A unsymmetrical squaraine dyes has been prepared by Shafeekh et al. [89] which showed a selective and sensitive affinity towards Hg 2+ in methanol. This probe demonstrated color change from blue to violet with LOD of 15 × 10 −6 M [89]. ...
... 15,21−25 A conceptually appealing essential state model (ESM) to intuitively account for the most salient electronic and optical properties of such quadrupolar dyes has been introduced by Painelli and coworkers. 1,24,26,27 It considers the molecules as being composed of two polar dyes in either a neutral ground |DA⟩ or charge-separated excited state |D + A − ⟩, connected via a charge-accepting linker group. Consequently, three essential electronic states are identified as a minimum (diabatic) basis for quadrupolar dyes: a neutral state |N⟩ = |DAD⟩ and two charge-separated states |Z 1 ⟩ = |D + A − D⟩ and |Z 2 ⟩ = |DA − D + ⟩. ...
... P-cymene, limonene, α-terpinene, αpinene, camphene, camphor, 1,4-cineole, β-pinene, α-Phellandrene, α-phellandrene, and 3-carene are among the monoterpenes found in Cinnamomum zeylanicum [19][20] . Because there are so many essential oils, isolating and separating them might take a long time 21 . The hydrodistillation method is the most often utilised separation method. ...