KD McReynolds’s scientific contributions

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Publications (1)


Gp120 Binds Cooperatively to Several Biologically Relevant Glycosphingolipids: Quantitative Measurements at Equilibrium by Total Internal Reflection Fluorescence Microscopy This research was supported by the NIH (AI40359-02), the NSF (CHE-9726132 and CHE-9623583), Eli Lilly (JGH), and the Alfred P. Sloan Foundation (J.G.H.). K.D.M. gratefully acknowledges receipt of the University of Arizona Dean's Fellowship and the Department of Chemistry Carl S. Marvel Fellowship. We thank Ying-Mei Gu for per
  • Article

September 2000

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14 Reads

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13 Citations

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KD McReynolds

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SS Saavedra

Citations (1)


... Later it was also shown that HIV particles prefer to bind at the edges of cholesterol-rich lipid domains that were reconstituted in supported bilayers [86,87]; however, observing this preference in live cells due to the small scale and dynamism of lipid rafts is difficult, illustrating the power of using an in vitro system for such studies. Focusing further on the receptors themselves, TIRF microscopy has also been used to measure the affinity of HIV glycoprotein 120 for the glycosphingolipids galactosyl ceramide, glucosylceramide, lactosylceramide and α-hydroxy glucosylceramide in SLBs [88,89]. The affinity of glycoprotein 120 for these lipids is roughly 5 times lower than its affinity for CD4 [90]. ...

Reference:

Single Virion Tracking Microscopy for the Study of Virus Entry Processes in Live Cells and Biomimetic Platforms
Gp120 Binds Cooperatively to Several Biologically Relevant Glycosphingolipids: Quantitative Measurements at Equilibrium by Total Internal Reflection Fluorescence Microscopy This research was supported by the NIH (AI40359-02), the NSF (CHE-9726132 and CHE-9623583), Eli Lilly (JGH), and the Alfred P. Sloan Foundation (J.G.H.). K.D.M. gratefully acknowledges receipt of the University of Arizona Dean's Fellowship and the Department of Chemistry Carl S. Marvel Fellowship. We thank Ying-Mei Gu for per
  • Citing Article
  • September 2000