K Suresh’s scientific contributions

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Publications (1)


Fig. 1. Prevalence of Restless Legs Syndrome (RLS) among parkinsonian disorders. PD e Parkinson's Disease, PSP e Progressive Supranuclear Palsy, MSA e Multiple System Atrophy, DLB e Dementia with Lewy Bodies.
Table 1 Comparison between patients and controls.
Table 3 Clinical features of PD patients with and without RLS.
Prevalence of Restless Legs Syndrome (RLS) among parkinsonian disorders. PD – Parkinson's Disease, PSP – Progressive Supranuclear Palsy, MSA – Multiple System Atrophy, DLB – Dementia with Lewy Bodies.
Prevalence and profile of Restless Legs Syndrome in Parkinson's disease and other neurodegenerative disorders: A case-control study
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January 2013

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245 Reads

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96 Citations

Parkinsonism & Related Disorders

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K Suresh

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Background: Restless Legs Syndrome (RLS) is associated with impaired central dopaminergic neurotransmission. Though a link between RLS and parkinsonism has been proposed, the prevalence of RLS in parkinsonian disorders is poorly documented. Objective: To determine the prevalence of RLS in patients with Parkinson's Disease (PD), Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA) and Dementia with Lewy Bodies (DLB). Methods: We evaluated 187 consecutive patients with parkinsonian disorders (PD = 134, PSP = 27, MSA = 21, DLB = 5) and 172 healthy controls. RLS was diagnosed using the International RLS Study Group (IRLSSG) criteria and the severity of RLS was assessed in patients with definite RLS. Quality of sleep was evaluated with established scales. Results: The prevalence of RLS was higher in patients compared to controls (9.6% vs. 2.9%; p = 0.009) and was highest in PD (11.9%). RLS was present in only one patient each with MSA and PSP and none with DLB. The mean IRLSSG severity score of patients was 16.2 ± 6.5. The global Pittsburgh Sleep Quality Index score and Epworth Sleepiness Scale score were significantly higher in patients compared to controls (p < 0.001). PD patients with RLS had lower Parkinson's Disease Sleep Scale (PDSS) score compared to patients without RLS (p = 0.023). There was no significant difference in gender, age, duration and severity of PD between the two groups. Conclusions: Our study found a higher prevalence of RLS in PD compared to healthy controls or other parkinsonian disorders. Apart from PDSS score, there was no significant difference in the clinical characteristics of PD patients with and without RLS.

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Citations (1)


... This suggests that males and females with PD share similar predisposition to RLS and OSA. However, some studies have reported notable differences in RLS among their cohorts (22,23), indicating potential sex differences dependent on additional factors such as environmental exposures. ...

Reference:

Sex differences in sleep disorders of Parkinson’s disease patients associated with a genetic risk variant
Prevalence and profile of Restless Legs Syndrome in Parkinson's disease and other neurodegenerative disorders: A case-control study

Parkinsonism & Related Disorders