K N Patel’s scientific contributions

Comparative Pharmacognostical studies of Anisomeles Linn. R. Br. species (Lamiaceae) in India are carried out. These species are Anisomeles indica L. Kuntze (Syn. A. Ovata R. Br.) and Anisomeles malabarica L. R. Br. Ex Sims, which are highly found in throughout south (Deccan plateau) and northeastern India. The study conducted with the aim of drawing the Pharmacognostical standards for differentiate the species. Macroscopical and microscopical characters, physio-chemical constants, quantitative microscopy parameters, extractive values, fluorescence analysis of extracts, its reaction after treatment with chemical reagents under visible light and UV light carried out. Preliminary phytochemical screening and TLC fingerprint on the various extracts from aerial part of Anisomeles species was also studied. According to the anatomical comparison between two species, the pith structure, sclerenchyma ring of the stems, the cuticle thickness of the leaves, and stomatal distribution on the leaves are the distinguishing features of the species. The determination of these characters will help future researchers in their Phytochemical as well as Pharmacological analysis of this species.

Comparative Pharmacognostical studies of Anisomeles Linn. R. Br. species (Lamiaceae) in India are carried out. These species are Anisomeles indica L. Kuntze (Syn. A. Ovata R. Br.) and Anisomeles malabarica L. R. Br. Ex Sims, which are highly found in throughout south (Deccan plateau) and northeastern India. The study conducted with the aim of drawing the Pharmacognostical standards for differentiate the species. Macroscopical and microscopical characters, physio-chemical constants, quantitative microscopy parameters, extractive values, fluorescence analysis of extracts, its reaction after treatment with chemical reagents under visible light and UV light carried out. Preliminary phytochemical screening and TLC fingerprint on the various extracts from aerial part of Anisomeles species was also studied. According to the anatomical comparison between two species, the pith structure, sclerenchyma ring of the stems, the cuticle thickness of the leaves, and stomatal distribution on the leaves are the distinguishing features of the species. The determination of these characters will help future researchers in their Phytochemical as well as Pharmacological analysis of this species.

Pharmacognostical parameters for the leaves of Anisomeles indica Linn. (Labiatae) were studied with the aim of drawing the Pharmacognostical standards for this species. Macroscopical and microscopical characters, physio-chemical constants, quantitative microscopy parameters, extractive values with different solvents, fluorescence analysis of extracts, its reaction after treatment with chemical reagents under visible light and UV light at 254 nm and 366 nm. Preliminary phytochemical screening on the leaves Anisomeles indica was also studied. Caryophyllaceous stomata (in the upper and lower epidermis), glandular, non-glandular trichomes and starch grains were identified. The determination of these characters will help future researchers in their Phytochemical as well as Pharmacological analysis of this species.

Hemidesmus indicus R.Br. is a treasure of the forest and herbal wealth. It is being used as folk medicines and as an ingredient in Ayurveda and Unani preparations against diseases of blood, inflammation, diarrhea, urinary disorders and rheumatism etc. The objective of the present study was to evaluate the role of natural nephroprotectant Hemidesmus indicus for the treatment of congestive heart failure. Hemidesmus indicus extracts were evaluated by using salt water induced left ventricular hypertrophy in Spargue dawley rat model. The property was evaluated using serum creatinine, urea, SGOT, SGPT and urine albumin, creatinine, Na+, K+ and Ca++ as biochemical parameters and histopathological changes including myocyte diameter, neutrophil infiltration and cardiac hypertrophy. Results obtained from the present study indicates that aqueous and methanolic extracts have more significant inhibitory effect on salt water feeding induced severity of microalbuminuria, serum urea and creatinine, myocyte diameter and retention of Na+ and water and increases the serum calcium level. We conclude from the present study that, potent natural nephroprotectant Hemidesmus indicus is also a potent cardioprotective.