Jyotirmaya Behera's research while affiliated with University of Louisville and other places

Publications (39)

Article
Vascular dementia (VaD) is the second most common form of dementia after Alzheimer's disease (AD). Hypertension is the second leading risk factor for developing neurodegenerative disease. A recent study reported that Dietary salt promotes cognitive impairment through tau phosphorylation. However, the effect of ketone bodies or the precursor molecul...
Article
Autophagy is a highly evolutionarily conserved process in the eukaryotic cellular system by which dysfunctional organelles are selectively degraded through a series of processes of lysosomal activity and then returned to the cytoplasm for reuse. All cells require this process to maintain cellular homeostasis and promote cell survival during stress...
Article
Background: Obesity is becoming a global epidemic and reversing the pathological processes underlying obesity and metabolic co-morbidities is challenging. Obesity induced chronic inflammation including brain inflammation is a hallmark of obesity via the gut-brain axis. The objective of this study was to develop garlic exosome-like nanoparticles (Ga...
Article
Full-text available
Traumatic brain injury (TBI) is a damage to the brain from an external force that results in temporary or permanent impairment in brain functions. Unfortunately, not many treatment options are available to TBI patients. Therefore, knowledge of the complex interplay between gut microbiome (GM) and brain health may shed novel insights as it is a rapi...
Article
Rationale: Manipulation of the gut microbiome can prevent pathologic bone loss. However, the effects of probiotics on mitochondrial epigenetic remodeling and skeletal homeostasis in the high-fat diet (HFD)-linked obesity remains to be explored. Here, we examined the impact of probiotics supplementation on mitochondrial biogenesis and bone homeostas...
Article
Rationale: Emerging evidence indicates that the growth of blood vessels and osteogenesis is tightly coordinated during bone development. However, the molecular regulators of intercellular communication in the bone microenvironment are not well studied. Therefore, we aim to investigate whether BMMSC-Exo promotes osteogenesis and angiogenesis via tra...
Article
Ethanol (ET) causes cerebrovascular dysfunction by altering homocysteine (Hcy) metabolism and by causing oxidative stress. However, there are no strategies to prevent ET‐induced epigenetic deregulation of tight junction protein (hyper‐methylation) and endothelial cell permeability to date. Hydrogen sulfide (H2S) has an antioxidative, antiapoptotic,...
Article
Age-associated bone loss or osteoporosis is a common clinical manifestation during aging (AG). The mechanism underlying age-associated osteoblast dysfunction induced by oxidative damage in the mitochondria and loss of bone density remains elusive. Here, we demonstrated the effect of allyl sulfide (AS), a natural organosulfur compound, on mitochondr...
Article
The gut microbiota (GM) is referred to as the second gene pool of the human body and a commensal, symbiotic, and pathogenic microorganism living in our intestines. The knowledge of the complex interaction between intestinal microbiota and health outcomes is a novel and rapidly expanding the field. Earlier studies have reported that the microbial co...
Article
Homocysteine (Hcy) is detrimental to bone health in a mouse model of diet‐induced hyperhomocysteinemia (HHcy). However, little is known about Hcy‐mediated osteoblast dysfunction via mitochondrial oxidative damage. Hydrogen sulfide (H2S) has potent antioxidant, anti‐inflammatory, and antiapoptotic effects. In this study, we hypothesized that the H2S...
Article
Hydrogen sulfide (H 2 S) has been known as a gasotransmitter, and it contributes to various physiological and pathological processes. Multiple enzymes such as cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-Mercaptopyruvate sulfurtransferase (MST) produce endogenous H 2 S, and these are differentially expressed in the various tiss...
Article
Bone marrow (BM)-derived endothelial progenitor cells (EPCs) are the key players in angiogenesis and vascular function. Cystathionine-β-synthase (CBS), an H2S-generating enzyme in methionine metabolism, regulates the function of these EPCs. This study aims to examine whether CBS hyper-methylation contributes to the bone marrow endothelial progenito...
Article
The objectives of this study are to identify the mechanism of mitochondrial dysfunction during cerebral ischemic/reperfusion (I/R) injury and the therapeutic potential of tetrahydrocurcumin (THC) to mitigate mitochondrial dysfunction in experimental stroke model. In our study, 8–10 weeks old male C57BL/6 wild-type mice were subjected to middle cere...
Article
Full-text available
Previously, we have shown hyperhomocysteinemia (HHcy) to have a detrimental effect on bone remodeling, which is associated with osteoporosis. During transsulfuration, Hcy is metabolized into hydrogen sulfide (H2S), a gasotransmitter molecule known to regulate bone formation. Therefore, in the present study, we examined whether H2S ameliorates HHcy...
Article
Full-text available
Neoangiogenesis is a fundamental process which helps to meet energy requirements, tissue growth, and wound healing. Although previous studies showed that Peroxisome proliferator‐activated receptor (PPAR‐γ) regulates neoangiogenesis via upregulation of vascular endothelial growth factor (VEGF), and both VEGF and PPAR‐γ expressions were inhibited dur...
Article
Although hyperhomocysteinemia (HHcy) occurs due to the deficiency in cystathionine-β-synthase (CBS) causing skeletal muscle dysfunction, it is still unclear whether this effect is mediated through oxidative/endoplasmic reticulum (ER)-stress or both. Nevertheless, there is no treatment option available to improve HHcy-mediated muscle injury. Hydroge...
Article
Full-text available
Bone remodeling is a continuous lifelong process in the repair of micro-damage to bone architecture and replacement of aging tissue in bone. A failure to such process leads to pathological destructive bone diseases such as osteoporosis, rheumatoid arthritis, and osteoarthritis. However, this active process is regulated by; osteoclasts, which are in...
Article
Hydrogen sulfide (H2S) is a novel gasotransmitter produced endogenously in mammalian cells, which works by mediating diverse physiological functions. An imbalance in H2S metabolism is associated with defective bone homeostasis. However, it is unknown whether H2S plays any epigenetic role in bone loss induced by hyperhomocysteinemia (HHcy). We demon...
Conference Paper
Cerebral ischemic/reperfusion (I/R) injury is a major cause of stroke and is associated with the formation of leaky mitochondria leading to mitochondrial dysfunction. Tetrahydrocurcumin (THC), a major herbal antioxidant and anti-inflammatory compound, has shown to protect the brain against injury. The objectives of this study are to identify the me...
Article
Full-text available
Chronic ethanol/alcohol (AL) dosing causes an elevation in homocysteine (Hcy) levels, which leads to the condition known as Hyperhomocysteinemia (HHcy). HHcy enhances oxidative stress and blood-brain-barrier (BBB) disruption through modulation of endoplasmic reticulum (ER) stress; in part by epigenetic alternation, leading to cognitive impairment....
Article
Full-text available
Homocysteine (Hcy) causes endothelial dysfunction by inducing oxidative stress in most neurodegenerative disorders. This dysfunction is highly correlated with mitochondrial dynamics such as fusion and fission. However, there are no strategies to prevent Hcy induced mitochondrial remodeling. Tetrahydrocurcumin (THC) is an anti-inflammatory and anti-...
Conference Paper
Alcohol consumption is a potent inducer of oxidative stress. Previous data indicate that alcohol consumption induces mitochondrial dysfunction and free radical production in mouse cerebral cortex. Exercise has been recommended by clinicians as a secondary protective therapy; however, its effect on brain functions through mitochondrial interventions...
Conference Paper
AIM The aims of the present study were to investigate the effectiveness of exercise intervention on the bone loss in leptin receptor-deficiency (db/db) type 2 diabetes mellitus mice, and examined the influence of homocysteine (Hcy) and hydrogen sulfide (H2S) level to clarify its molecular mechanisms. METHODS Forty mice were used in our study, inclu...
Article
Alcohol is one of the most socially accepted addictive drugs in modern society. Its abuse affects virtually all organ systems with the central nervous system (CNS) being particularly vulnerable to excessive alcohol exposure. Alcohol exposure also causes profound damage to both the adult and developing brain. Excessive alcohol consumption induces nu...
Article
Full-text available
In the last few decades, perturbation in methyl-group and homocysteine (Hcy) balance have emerged as independent risk factors in a number of pathological conditions including neurodegenerative disease, cardiovascular dysfunction, cancer development, autoimmune disease and kidney disease. Recent studies report Hcy to be a newly recognized risk facto...

Citations

... Consequently, it was found that ginseng-derived EVs can inhibit tumor growth in mice [62]. Furthermore, another interesting study reported that leaf-derived extracellular vesicles from Dendropanax morbifera can inhibit tyrosinase activity and also reduce melanin content in melanoma cells, representing a candidate for the development of new anti-melanogenic agents [65]. Kim et al. demonstrated in 2020 that Dendropanax Morbifera-EVs exerts cytotoxic effects on malignant breast and skin tumor cells, without affecting normal cells, while Pinus densiflora-EVs are cytotoxic toward malignant skin tumor cells, but not toward normal cells. ...
... In another study, oral IPA supplementation reduced the systemic inflammation level in radiation-exposed mice, restored hematopoietic organs, relieved bone marrow suppression, and improved gastrointestinal function and epithelial integrity after irradiation, thereby exerting therapeutic effects on radiation toxicity (56). Supplementation with mouse probiotic Clostridia resulted in an increase in IPA production in the intestinal lumen and increased mitochondrial transcription factor A (Tfam) expression in osteoblasts by promoting Kdm6b/Jmjd3 histone demethylase, thereby inhibiting the epigenetic methylation of H3K27me3 at the Tfam promoter from preventing pathological bone loss in obese mice induced by a HFD (57). IPA is neuroprotective as a potent hydroxyl radical scavenger (58). ...
... The study of Behera and colleagues demonstrated both in vitro and vivo that lnc-H19 in BMMSC-exosomes significantly promoted endothelial angiogenesis and osteogenesis through binding Frontiers in Pharmacology | www.frontiersin.org June 2022 | Volume 13 | Article 912303 with miR-106 and activating Angpt1/Tie2-NO signaling pathway in mesenchymal and endothelial cells (Behera et al., 2021). These findings demonstrated the mediating ability of exosomal lncRNAs in the pathological process of tumors. ...
... Recent large meta-analyses of human studies have also confirmed that supplementation with probiotics and/or prebiotics reduced levels of oxidative stress, as evidenced by reduced levels of protein carbonylation and lipid peroxidation and increased total antioxidant capacity, most notably by increasing levels of GSH (352)(353)(354). The potential therapeutic utility of probiotic and or prebiotic supplementation is further emphasised by a wealth of published in vivo data demonstrating localised and systemic inflammation, as evidenced by reduced levels of PICs in the periphery and the brain among patients suffering from a range of chronic illnesses (355)(356)(357)(358)(359)(360)(361). ...
... That study demonstrated that SAC not only regulated TNF-α, IL-17 and matrix metalloprotease 9 levels, but was also capable of attenuating inflammatory cell infiltration, axonal demyelination and axonal loss in the lumbar spinal cord (58). Additionally, another study used allyl sulfide in aging mice and demonstrated that it ameliorated gut dysbiosis and memory functions associated with lncRNA-Hotair regulation and H3K27ac regulatory activity (59). Taken together, these neuroprotective effects, namely the reduction of oxidative stress and inflammatory responses may be the key underlying benefits for SAC against neurodegeneration. ...
... The number of infections, although significantly lower in probiotic-treated patients, sounds high for both groups, given that the patients were mostly young, healthy, and without comorbidities, but it clearly reflects the type of surgeries: most patients presenting with at least one open fracture requiring internal or external fixation, and we should not underestimate the significance of the fact that all patients suffered a brain trauma, the severity of which required emergency intubation and mechanical ventilation. Furthermore, a brain injury of any kind promotes a decrease in Bacteroidetes, Firmicutes, and Verrucomicrobia and an increase in the Clostridia and Enterococcus populations [29][30][31]. Alterations in the gut microbiome composition favoring pathogenic over commensal bacteria have deleterious effects on both the CNS and the GI tract. The brain-gut axis is a bidirectional pathway that is critical for both the central nervous system and gut homeostasis, regulating diverse functions, including visceral pain, intestinal barrier function, gut motility, and neurobehavior [32]. ...
... To further evaluate the role of H3K27me3 in RA, we upregulated H3K27me3 level in keen joint tissues in CIA mice with EZH2 knockdown and our experiments revealed that H3K27me3 upregulation led to reductions in Ndrg2 mRNA level and levels of RUNX2 and BMP2 and an increase in TRAP-positive cells. In favor of our results, accumulating evidence has suggested that epigenetic inhibition ofH3K27me3 on the promoter of osteogenesis-regulated genes, such as Runx2, Alpl, and osterix, accelerates OBLD [40][41][42]. Therefore, it is plausible to suggest that the role of EZH2 in OBLD and OCLD in CIA mice is associated with the promotion of H3K27me3 and the inhibition of Ndrg2 transcription. ...
... It has been shown that acute or long-term exercise can induce PGC-1α expression in tissues resulting in the induction of FNDC5 production and increases irisin secretion as a myokine (7). Although various studies introduce exercise as an irisin-augmenting factor in rats (2, 8,9), conflicting results have been reported about humans (10, 11). However, Bostrom et al. (2012) revealed irisin elevation following exercise in humans (12). ...
... For example, diabetes is associated with reduced microbiome diversity [91], whereas osteoporosiswith increased diversity [90]. There are numerous reports on probable favorable effects of probiotic administration on bone health [90,92,93]. Berberine is only slightly absorbed from the gastrointestinal tract; it achieves there high concentrations and is known to modulate the microbiome composition. ...
... L-cystenine is also catalyzed by cysteine aminotransferase (CAT) to produce 3-mercaptopyruvate (3-MP), by transferring its amines to α-ketoglutarate. 3-MP is catalyzed by 3-MST to be converted into H 2 S ( Figure 2) [27,28]. H 2 S contributes to many physiological processes, including anti-apoptosis [29], antioxidant stress [30], anti-inflammation [31], vasodilation, decreased blood pressure [32,33], cell survival/death, cell differentiation, cell proliferation/hypertrophy and mitochondrial bioenergy/biogenesis [34]. ...