Jun Shi’s research while affiliated with Hubei University of Chinese Medicine and other places

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Publications (10)


Supplementary Material 4
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  • File available

January 2018

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5 Reads

Xingchun Peng

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Jun Shi

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Wanqun Sun

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[...]

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Bin Li
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Figure 1: Flow diagram of the study selection process. 
table 1 : characteristics of participants in included studies of tooth loss in relation to risk of cancer 
Figure 2: dose-response relationship between tooth loss in relation to risk of overall cancer. 
Table 2 : Stratified analyses of relative risk of cancer 
Figure 3: dose-response relationship between tooth loss in relation to risk of cancer. (A) Colorectal cancer. (b) Esophageal cancer. (c) Gastric cancer. (d) Head and neck cancer. 

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Tooth loss and cancer risk: A dose-response meta analysis of prospective cohort studies

July 2015

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46 Reads

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29 Citations

Oncotarget

Conflicting results to identify the relationship between tooth loss and cancer risk. Therefore, a dose-response meta-analysis was performed to clarify and quantitative assessed the correlation between tooth loss and cancer risk. Up to March 2017, 25 observational epidemiological studies were included in current meta-analysis. Tooth loss was significantly associated with a higher risk of cancer. Additionally, tooth loss was associated with significantly a higher risk of esophageal cancer, gastric cancer, head and neck cancer, colorectal cancer, pancreas cancer, lung cancer, prostate cancer, bladder cancer and hematopoietic cancer. Subgroup analysis showed consistent findings. Furthermore, a significant dose-response relationship was observed between tooth loss and cancer risk. Increasing per 10 of tooth loss was associated with a 9% increment of cancer risk, 14% increment of esophageal cancer risk, 9% increment of gastric cancer risk, 31% increment of head and neck cancer risk, 4% increment of colorectal cancer risk, 7% increment of pancreas cancer risk, 19% increment of lung cancer risk, 2% increment of bladder cancer risk and 3% increment of hematopoietic cancer risk. Considering these promising results, tooth loss might be harmful for health. Large sample size, different ethnic population and different cancer type are warranted to validate this association.


Figure 1: Flow diagram of the study selection process. 
Figure 2: Dose-response relationship between NSAIDs using and head and neck cancer. (The solid line represents fitted non-linear trend, the dotted line represents the 95% confdence interval). 
Figure 3: Dose-response relationship between aspirin using and head and neck cancer. (The solid line represents fitted non 
Figure 4: Dose-response relationship between other NSAIDs using and head and neck cancer. (The solid line represents fitted non-linear trend, the dotted line represents the 95% confdence interval). 
Nonsteroidal anti-inflammatory drugs using and risk of head and neck cancer: A dose-response meta analysis of prospective cohort studies

July 2015

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48 Reads

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23 Citations

Oncotarget

Conflicting results identifying the relationship between nonsteroidal anti-inflammatory drugs using and head and neck cancer risk. Therefore, we performed this meta-analysis to clarify and quantitative assessed the relationship between nonsteroidal anti-inflammatory drugs using and head and neck cancer risk. Up to March 2017, 11 original publications were included in this meta-analysis. Our results showed statistically significant association between nonsteroidal anti-inflammatory drugs using and head and neck cancer risk reduction. Subgroups analysis indicated that Aspirin, COX 2 inhibitors, Ibuprofen and Other NSAIDs were associated with a significantly risk reduction of head and neck cancer. Furthermore, nonsteroidal anti-inflammatory drugs using was associated with a significantly lower risk of oral and oropharynx cancer, larynx cancer and hypopharynx cancer. In addition, increasing nonsteroidal anti-inflammatory drugs using (per 2 prescriptions/week increment) was associated with a 4% reduction in head and neck cancer risk, 5% reduction of aspirin using and 6% reduction of other nonsteroidal anti-inflammatory drugs using. Considering these promising results, increasing nonsteroidal anti-inflammatory drugs using might provide health benefits. More studies and large sample size are warranted to validate this association.


Figure 1: Flow diagram of the study selection process. 
Table 1 : Meta-analysis of IL-6 promoter polymorphisms and cancer susceptibility 
Table 2 : Meta-analysis of IL-6 promoter polymorphisms and cancer risk in ethnicity 
Table 7 : Publication bias analysis of the meta-analysis 
Genetic polymorphisms of IL-6 promoter polymorphisms in cancer susceptibility and prognosis: a meta-analysis

July 2015

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99 Reads

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48 Citations

Oncotarget

IL-6 is critical for tumorigenesis. However, previous studies on the association of IL-6 promoter polymorphisms with predisposition to different cancer types are somewhat contradictory. Therefore, we performed this meta-analysis regarding the relationship between IL-6 promoter single nucleotide polymorphisms and cancer susceptibility and prognosis. Up to April 2017, 97 original publications were identified covering three IL-6 promoter SNPs. Our results showed statistically significant association between IL-6 promoter and cancer risk and prognosis. Subgroup analysis indicated that rs1800795 was significantly associated with increased risk of cervical cancer, colorectal cancer, breast cancer, prostate cancer, lung cancer, glioma, non-Hodgkin's lymphoma and Hodgkin's lymphoma but not gastric cancer and multiple myeloma. Furthermore, rs1800796 was significantly associated with increased risk of lung cancer, prostate cancer and colorectal cancer but not gastric cancer. Additionally, rs1800797 was significantly association with breast cancer, non- Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer. Simultaneously, rs1800795 and rs1800796 were associated with a significantly higher risk of cancer in Asia and Caucasian, rs1800797 was associated with a significantly risk of cancer in Caucasian but not in Asia. Furthermore, IL-6 promoter polymorphisms were significantly associated with the prognosis of cancer. Considering these promising results, IL-6 promoter including rs1800795, rs1800796 and rs1800797 may be a tumor marker for cancer therapy.

Citations (3)


... The study revealed a significant difference in IL-6 (rs1800795) genotypes and alleles between cases and controls. In addition, a meta-analysis study has confirmed that the IL-6 rs1800795 has a significant linkage with elevated lung cancer incidence (P = 0.003, for alleles) and in Caucasian and Asian populations (P < 0.001, P = 0.003, for alleles, respectively) (Peng et al., 2018). ...

Reference:

Association of IL-6 rs1800795 and IL-1 β rs16944 Polymorphisms with non-small Cell Lung Cancer in the Egyptian Population: a Pilot Study
Genetic polymorphisms of IL-6 promoter polymorphisms in cancer susceptibility and prognosis: a meta-analysis

Oncotarget

... But this was attributed to the frequency of partial tooth loss as opposed to completely edentulous patients. Moreover, tooth loss has been shown to increase the risk of oral cancer by 3 folds even after controlling for alcohol use and smoking [40]. With regular care, even for edentulous patients, the chances of cancer detection are increased. ...

Tooth loss and cancer risk: A dose-response meta analysis of prospective cohort studies

Oncotarget

... A dose-relationship meta-analysis reported that an increase of 2 prescriptions/week of NSAIDs resulted in a 4 % decrease in head and neck cancer risk with statistical significance (RR = 0.96, 95 % CI = 0.94-0.99, P < 0.001) [24]. The highest dose of NSAID consumption also correlated with a lower risk of both incidence and recurrence of hepatocellular carcinoma than did the lowest dose of NSAID intake [25]. ...

Nonsteroidal anti-inflammatory drugs using and risk of head and neck cancer: A dose-response meta analysis of prospective cohort studies

Oncotarget