Jun Fang's research while affiliated with Tsinghua University and other places

Publications (23)

Preprint
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Cuproptosis is the most recently identified copper-dependent cell death form that influences tricarboxylic acid (TCA) cycle. However, the relationship between cuproptosis and clinical prognosis, tumor microenvironment infiltration (TME), and response to immunotherapy remains unclear. Thus, we performed the following analysis. Single-sample gene-set...
Article
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Background Napsin B Aspartic Peptidase, Pseudogene (NAPSB) was associated with CD4 + T cell infiltration in pancreatic ductal adenocarcinoma. However, the biological role of NAPSB in hepatocellular carcinoma (HCC) remains to be determined. Methods The expression of NAPSB in HCC as well as its clinicopathological association were analyzed using dat...
Article
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Understanding the interaction between complicated geophysical flows and barriers remains a critical challenge for hazards countermeasures in engineering design. In this study, the impact of geophysical flows on a rigid barrier is studied numerically using coupled computational fluid dynamics and discrete element method (CFD-DEM). Three types of flu...
Article
Background and study aim Chronic atrophic gastritis plays an important role in the process of gastric cancer. Deep learning is gradually introduced in the medical field, and how to better apply a convolutional neural network (CNN) to the diagnosis of chronic atrophic gastritis remains a research hotspot. This study was designed to improve the perfo...
Article
Constructing multiple-barrier systems is efficient in mitigating flow-like geological hazards and potentially serves as an optimal solution to protect the heavily threatened infrastructures, such as the ongoing Sichuan–Tibet railway in China. However, the design of the multiple-barrier system remains essentially empirical, which hinders the develop...
Preprint
Background Napsin B Aspartic Peptidase, Pseudogene (NAPSB) was associated with CD4 + T cell infiltration in pancreatic ductal adenocarcinoma. But the biological role of NAPSB in hepatocellular carcinoma (HCC) remains to be determined. Methods The expression of NAPSB in pan-cancer and HCC as well as its clinicopathological association were analyzed...
Preprint
Background: Napsin B Aspartic Peptidase, Pseudogene (NAPSB) was associated with CD4+ T cell infiltration in pancreatic ductal adenocarcinoma. But the biological role of NAPSB in hepatocellular carcinoma (HCC) remains to be determined. Methods: The expression of NAPSB in pan-cancer and HCC as well as its clinicopathological association were analyzed...
Article
Full-text available
Background: Ulcerative colitis (UC) is a chronic recurrent disease of unknown etiology. Recently, it has been reported that autophagy-related gene polymorphism is closely associated with increased risk of UC, and the therapeutic effect of some UC drugs is mediated by regulating autophagy pathways. This study aims to identify pivotal autophagy-relat...
Article
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Introduction Endoscopic retrograde cholangiopancreatography (ERCP) is considered to be a challenge in patients with surgically altered anatomy. We aimed to identify the risk factors of ERCP-related adverse events in patients with surgically altered anatomy in our center. Methods We included patients with surgically altered anatomy who underwent ER...
Preprint
Full-text available
Introduction : Endoscopic retrograde cholangiopancreatography (ERCP) is considered to be a challenge in patients with surgically altered anatomy. We aimed to identify the risk factors of ERCP-related adverse events in patients with surgically altered anatomy in our center. Methods We included patients with surgically altered anatomy who underwent...
Article
Background and Aims There are many deficiencies of existing biliopancreatic duct endoscopy in the examination of early biliary and pancreatic tumors. This study aimed to evaluate the usefulness and feasibility of a novel ultrafine separable biliopancreatic duct endoscopy device with dual modalities of intraductal ultrasonography (IDUS) and optical...
Preprint
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Background: Glomus tumors are exceedingly rare tumors arising from the normal glomus body. Only a very few cases of glomus tumors located in the small intestine were reported to date. Here, we present a case of glomus tumor of the jejunum in a 30-year-old female patient, and discuss its clinical, imaging, and pathologic features. Case presentation:...
Preprint
Full-text available
Glomus tumors are exceedingly rare tumors arising from the normal glomus body. Only a very few cases located in the small intestine were reported to date. Here, we present a case of glomus tumor of the jejunum in a 30-year-old female patient, and discuss its clinical, imaging, and pathologic features.
Preprint
Full-text available
Background Glomus tumors are exceedingly rare tumors arising from the normal glomus body. Only a very few cases of glomus tumors located in the small intestine were reported to date. Here, we present a case of glomus tumor of the jejunum in a 30-year-old female patient, and discuss its clinical, imaging, and pathologic features.Case presentationA 3...
Article
Full-text available
Background Hepatocellular carcinoma (HCC) remains a major global health burden due to its high prevalence and mortality. Emerging evidence reveals that microRNA (miRNA) plays a vital role in cancer pathogenesis and is widely involved in the regulation of signaling pathways via their targeting of downstream genes. MiR-21-3p, a liver-enriched miRNA,...
Article
Full-text available
Background: Memory CD8+T cell responses play an essential role in protection against persistent infection. However, HIV-1 evades vaccine-induced memory CD8+T cell response by mechanisms that are not fully understood. Methods: We analyzed the temporal dynamics of CD8+T cell recall activity and function during EcoHIV infection in a potent PD1-base...
Article
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Background: Consumption of ultra-processed foods (UPFs) plays a potential role in the development of obesity and other diet-related noncommunicable diseases (NCDs), but no studies have systematically focused on this. This study aimed to summarize the evidence for the association between UPFs consumption and health outcomes. Methods: A comprehens...
Article
Objectives Describe the clinical characteristics of patients in Fangcang Hospital. Methods Non-critically ill patients with positive SARS-CoV-2 RT-PCR tests admitted to Dongxihu ‘Fangcang’ Hospital between February 7th and 12th were included, which was promptly constructed because of the rapid, exponential increase in COVID-19 patients in Wuhan, C...
Article
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Isolation of viable circulating tumor cells (CTC) holds the promise for improving screening, early diagnosis, and personalized treatment of lymphoma. In this study, we isolated and characterized spontaneously immortalized B‐lymphocyte (SIBC) lines from HIV‐infected patients with and without Non‐Hodgkin's Lymphoma (AIDS‐NHL). A total of 22 SIBC line...
Article
Newly emerging viruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle Eastern respiratory syndrome CoVs (MERS-CoV), and H7N9, cause fatal acute lung injury (ALI) by driving hypercytokinemia and aggressive inflammation through mechanisms that remain elusive. In SARS-CoV/macaque models, we determined that anti-spike IgG (S-...
Article
Full-text available
BACKGROUND Postoperative pancreatitis is one of the most serious complications in endoscopic retrograde cholangiopancreatography (ERCP). To detect potential risk factors for post-ERCP hyperamylasemia and pancreatitis. MATERIAL AND METHODS We reviewed 1786 ERCP procedures in Zhongnan Hospital of Wuhan University from January 2015 to April 2018. Clin...

Citations

... The discrete element method (DEM) was developed by Cundall and Strack (1979) to simulate solid particle dynamics. In recent years, DEM is applied in simulation of geophysical flows (Goodwin and Choi, 2021;Cui et al., 2022;Guo et al., 2022). With DEM, the model is first globally searched to count the contact points and then the normal distances of the overlapping parts between the discrete elements are calculated. ...
... It is well established that miR-21 is strongly connected with the Hippo-YAP/TAZ signaling pathway . Recently, Hong et al. (2021) showed that miR-21-3p levels are substantially increased in HCC tissues compared to the adjacent healthy liver tissues, and the targets of this miRNA exhibited a significant association with the TGF-β transduction and Hippo-YAP/TAZ signaling pathway. Moreover, they demonstrated that one of the most significant targets of miR-21-3p, intranuclear SMAD7, promotes YAP1 translocation to the cytoplasm and hinders YAP1 transcription. ...
... Currently, we recognize that various factors are involved in stimulating the expansion of MDSCs during HIV infection, including the virus itself and its proteins (such as gp120 and Tat proteins), Gram-negative bacterial byproducts consequent to microbial translocation such as lipopolysaccharide, and inflammatory molecules produced in response to both HIV replication and microbial translocation. In contrast, MDSCs contribute to the pathogenesis of HIV infection by four major mechanisms: (i) inhibition of anti-HIV immune responses, (ii) enhancing HIV replication, (iii) hampering with the recovery of normal CD4 + T cells counts even under successful antiretroviral therapy, and possibly (iv) MDSCs may be directly infected by the virus and resist the killing mediated by cytotoxic T cells (2,4,9,10,15,23,25,(27)(28)(29)37). All of these mechanisms, particularly the latter one, indicate that MDSCs could provide a strategy for the virus to establish a chronic infection, one way or another. ...
... This has created a higher preference for convenience foods that are often highly processed and contain excessive sugar, salt and saturated fat. In addition, with increased urban incomes, preferences for and consumption of animal-source and ultra-processed foods increase 76,77 . While these dietary shifts have led to lower micronutrient deficiencies among the affluent urban population, in the longer run, they have also led to a substantial rise in cardiometabolic diseases due to imbalanced and unhealthy diets and lower physical activity [78][79][80][81][82][83] . ...
... Covid-19 vakalarının büyük kısmı nispeten hafif bir klinik seyir göstererek iyileşirken bazı Covid-19 hastalarında hastalığın başlangıcından sonraki bir hafta içinde düzensiz immün yanıta bağlı olarak hastaneye yatmayı hatta yoğun bakım ünitesine alınmayı gerektiren koagülopati, masif alveoler hasar ve ilerleyici solunum yetersizliği gelişmekte ve maalesef bu hastaların bir kısmı ölmektedir (4)(5)(6). Bu durum hastalıkla daha etkin mücadele etmeyi, sınırlı hastane ve yoğun bakım kaynaklarının rasyonel kullanımı için yüksek riskli vakaların erkenden belirlenmesinde kanıta dayalı etkin bir triyaj sisteminin gerekliliğini ortaya koymuştur. Pandeminin ilk aşamalarında, Covid-19 hastalarında risk sınıflaması ve prognoz öngöründe klinik değerlendirmeler ve radyolojik bulguları temel alan çalışmalar hız kazanmış, ilerleyen dönemde bunlara C-reaktif protein (CRP), d-dimer, interlökin-6, kan sayımı parametreleri klinik laboratuvar sonuçları da eklenmiştir (6)(7)(8)(9)(10). ...
... Huang et al analyzed the rst 41 cases with COVID-19, and found that compared with non-ICU patients, ICU patients had higher plasma levels of cytokines, which could be associated with disease severity [7] . Chen et al analyzed 21 cases with COVID- 19, and found that compared with moderate cases, severe cases had markedly higher levels of cytokines, and markedly lower numbers of T lymphocytes, CD4 + T cells, and CD8 + T cells [8] . Ulhaq et al also presented the evidence that circulating IL-6 levels are closely linked to the severity of COVID-19 [9] . ...
... The scoring system was developed according to the typical pathological changes of SARS-CoV-2 reported in Lu et al's study 35 and mainly referred to the scoring template of SARS-CoV described in Liu et al' work. 50 Multiple cytokine profiling Lung lobe and BALs were collected on day 7 post challenge. Lunglobe specimens were weighed, and supernatants of the homogenate were prepared for detection. ...
... En nuestro paciente se obtuvo un resultado de amilasa a las 12 horas post CPRE de 477,67 U/L, el cual es compatible con el diagnóstico de hiperamilasemia, siendo ésta una de las complicaciones más frecuentes de la CPRE, con una incidencia reportada entre el 6,8% y el 70% de pacientes sometidos a ella. De esta forma se aleja la posibilidad de pancreatitis aguda post CPRE, debido a que las características del dolor abdominal no cumplen los criterios de pancreatitis (11,12) . ...