Julia Erhardt's research while affiliated with Universität Stuttgart and other places

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Publications (5)

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Figure 1. Proliferation dynamic of a single myocyte. Shown is an...
Figure 3. Cell area dependence on functionalized rigid hydrogels. (A)...
Figure 4. Cross-talk between hydrogel rigidity and fibronectin density....
Figure 5. Actin cytoskeleton formation dependence on fibronectin...
+2 Figure 6. Proliferation dynamic of a single myocyte on a rigid...
Optimization of Mechanosensitive Cross-Talk between Matrix Stiffness and Protein Density: Independent Matrix Properties Regulate Spreading Dynamics of Myocytes
Article
Full-text available
  • Jul 2022
Cells actively sense differences in topology, matrix elasticity and protein composition of the extracellular microenvironment and adapt their function and morphology. In this study, we focus on the cross-talk between matrix stiffness and protein coating density that regulates morphology and proliferation dynamics of single myocytes. For this, C2C12...
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Figure 1. Proliferation dynamic of a single myocyte. Shown is an...
Figure 2. Property assessment of the poly-acrylamide hydrogels. A...
Hydrogel preparation.
Protocol for fibronectin coating densities.
Optimization of Mechanosensitive Cross-talk between Matrix Stiffness and Protein Density: Independent Matrix Properties Regulate Spreading Dynamics of Myocytes
Preprint
Full-text available
  • Jun 2022
Cells actively sense differences in topology, matrix elasticity and protein composition of the extracellular microenvironment and adapt their function and morphology. In this study, we focus on the cross-talk between matrix stiffness and protein coating density that regulate morphology and proliferation dynamics of single myocytes. For this, C2C12...
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FIGURE 1 | Fourier analysis in a high-frequency entrained canine heart....
FIGURE 2 | Simultaneous DA of different AP rhythms in a high-frequency...
FIGURE 3 | Pacing-site-dependent frequency maps. (A) shows frequency...
FIGURE 4 | Stabilization of nodal line formation at higher entrainment...
+2 FIGURE 5 | Optical ultrastructure extracted from the low-frequency...
Optical Ultrastructure of Large Mammalian Hearts Recovers Discordant Alternans by In Silico Data Assimilation
Article
Full-text available
  • Apr 2022
Understanding and predicting the mechanisms promoting the onset and sustainability of cardiac arrhythmias represent a primary concern in the scientific and medical communities still today. Despite the long-lasting effort in clinical and physico-mathematical research, a critical aspect to be fully characterized and unveiled is represented by spatiot...
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Citations

... The critical combination of both properties, however, is crucial to maintain cellular integrity and functionality, as we have shown in this study. More sensitive myocyte cultures, such as embryonic and inducible pluripotent stem cells [20], as well as primary cultures of neonatal animals [2], may be affected even stronger, and therefore, might be responsible for the life-threatening induction of alternans, where mechanoregulation, tissue arrangement and synchonization dynamics play an essential role [2,52,53]. The methodology and results presented in this manuscript provide a fundamental platform to investigate more complex myocyte dynamics, such as the proliferation dynamics of cells in crowded cell environments and differentiation dynamics of pluripotent cells in organoids, as cell shape may be stabilized by the tight junctions of neighboring cells and therefore also influence actin depolymerization dynamics. ...
Reference: Optimization of Mechanosensitive Cross-Talk between Matrix Stiffness and Protein Density: Independent Matrix Properties Regulate Spreading Dynamics of Myocytes
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