Jui-Teng Lin's research while affiliated with New Taipei City Hospital and other places

Publications (76)

Preprint
The synergistic features of a three-component, photoinitiating system (A/B/C) based on the measured data and proposed mechanism of Liu et al. are analyzed. The co-initiators/additives B and C have dual-functions of : (i) regeneration of photoinitiator A, and (ii) generation of extra radicals for enhanced conversion efficacy (CE). The synergistic ef...
Article
Full-text available
This article presents, for the first time, the efficacy and curing depth analysis of photo-thermal dual polymerization in metal (Fe) polymer composites for 3D printing of a three-component (A/B/M) system based on the proposed mechanism of our group, in which the co initiators A and B are Irgacure-369 and charge–transfer complexes (CTC), respectivel...
Article
This article presents, for the first time, the kinetics and the general conversion features of a 3-component system, benzophenone–triphenylamine(BT)/iodonium/Amine, based on proposed mechanism of Liu et al., for both free radical polymerization (FRP) of acrylates and the free radical promoted cationic polymerization (CP) of epoxides using the new m...
Preprint
This article presents, for the first time, the efficacy and curing depth analysis of photo-thermal dual polymerization in metal (Fe) polymer composites for 3D printing of a 3-component (A/B/M) system based on the proposed mechanism of our group, in which the co initiators A and B are Irgacure-369, and charge-transfer complexes (CTC), respectively;...
Article
Purpose: To analyze the factors influencing the corneal crosslinking (CXL) efficacy and comparison of epi-on and epi-off procedures. Study Design: modeling the efficacy of epi-off and epi-on CXL. Place and Duration of Study: New Taipei City, Taiwan, between November, 2021 and December, 2021. Methodology: Solving the rate equations for the CXL effic...
Article
Purpose: To explore (theoretically) the key parameters and their influence on the time profiles of photosensitizer (riboflavin), free radicals, singlet oxygen, oxygen and the efficacy of corneal collagen crosslinking (CXL) in both type-I and oxygen-mediated type-II mechanisms, specially the role of oxygen and the initiator regeneration. Study Desig...
Article
Full-text available
This article presents, for the first time, the kinetics and the general features of a photopolymerization system (under visible light), copper-complex/Iodonium/triethylamine/gold-chloride (orA/B/N/G), with initial concentrations of A0, B0, N0 and G0, based on the proposed mechanism of Tar et al. Analytic formulas were developed to explore the new f...
Preprint
Purpose:To explore (theoretically) the key parameters and their influence on the time profiles of photosensitizer (riboflavin), free radicals, singlet oxygen, oxygen and the efficacy of corneal collagen crosslinking (CXL)in both type-I and oxygen-mediated type-II mechanisms, specially the role of oxygen and the initiator regeneration. Methodology:C...
Article
Aims: To resolve the controversial issues of UV-light-initiated corneal collagen cross-linking (CXL) by theoretical formulas and measured clinical outcomes. Study Design: Analysis and measured data of CXL. Place and Duration of Study: New Vision Inc, Taipei, between June 2021 and August 2021. Methodology: The controversial issues are addressed and...
Preprint
To resolve the controversial issues of UV-light-initiatedcornealcollagen cross-linking (CXL) by theoretical formulas and measured clinical outcomes. The controversial issues are addressed and resolved by analytical formulas including: the validation of Bunsen Roscoe law (BRL), the cutoff light intensity, the minimum corneal thickness, the demarcati...
Article
Purpose: To derive and provide analytic formulas for an accommodative gain of presbyopia eyes. via sclera ablation and/or thermal shrinkage such that the lens is reshaped and/or its position is shifted. New mechanisms are also proposed. Study Design: To increase the accommodation of presbyopia. Place and Duration of Study: New Taipei City, Taiwan,...
Article
Purpose: To update and review the technology and principles of laser presbyopia reversal (LAPR) via sclera ablation and thermal shrinkage using infrared and UV lasers. Recent clinical data and new methods are also summarized. Study Design: LAPR using laser sclera ablation for increased accommodation of presbyopic eyes. Place and Duration of Study:...
Article
Purpose: To update and derive formulas for the efficacy and kinetics of corneal collagen crosslinking (CXL) including both type-I and oxygen-mediated type-II mechanisms, the role of oxygen, the initiator regeneration, safety dose, minimum corneal thickness and demarcation line depth. Study Design: Modeling the kinetics of CXL in UV light and using...
Article
Full-text available
The synergic features and enhancing strategies for various photopolymerization systems are reviewed by kinetic schemes and the associated measurements. The important topics include (i) photo crosslinking of corneas for the treatment of corneal diseases using UVA-light (365 nm) light and riboflavin as the photosensitizer; (ii) synergic effects by a...
Preprint
Aims:To update analytic formulas for the overall efficacy of corneal collagen crosslinking (CXL) including both type-I and oxygen-mediated type-II mechanisms, the role of oxygen and the initiator regeneration. Study Design:modeling the kinetics of CXL in UV light and using riboflavin as the photosensitizer.Place and Duration of Study:New Taipei Cit...
Preprint
This article presents, for the first time, the kinetics and the general conversion features of free radical polymerization (FRP) in a 3-component system (A/B/N), with [A] being the initiator, and [B] and [N] are additives, based on the proposed mechanism of Rahal et al. Higher FRP can be achieved by additives [B] and [N], via the dual function of (...
Preprint
The synergetic features of a three-component photoinitiating systems(A/B/C) based on the measured data and proposed mechanism of Liu et al are analyzed. The co-initiators/additivesB and C have dual-functions of : (i) regeneration of photoinitiator A, and (ii) generation of extra radicals for enhanced conversion efficacy (CE), the synergic effects l...
Preprint
This article presents, for the first time, comprehensive model based on the proposed mechanism of Rahal et al [17], Bonardi {20], Tar et al [20], and Mau et al [24], for 3-component systems of G1/Iod/EDB, G1/Iod/amine (in gold chloride), and Iod/Benzoic/Borate (for reduced oxygen inhibition) for the hybri free radical (FRP) and cationic (CP) photop...
Preprint
. This article presents, for the first time, the kinetics and the general conversion features of a 3-component system (A/B/N), based on proposed mechanism of Mau et al, for both free radical polymerization (FRP) of acrylates and the free radical promoted cationic polymerization (CP) of epoxides using various new copper complex (G2) as the initiator...
Preprint
This article presents, for the first time, the kinetics and the general conversion features of a 3-component system, BT(BC)/iodonium/Amine, based on proposed mechanism of Liu et al, for both free radical polymerization (FRP) of acrylates and the free radical promoted cationic polymerization (CP) of epoxides using the new multi-functional initiator...
Preprint
Full-text available
. This article presents, for the first time, the kinetics and the general features of a photopolymerization system (under visible light) G1/ Iodonium/ TEA/gold chloride (or A/B/N/G), having initial concentrations of A0, B0, N0 and G0, based on the proposed mechanism of Tar et al. Analytic formulas are developed to explore the new features including...
Article
The kinetics for a 3-component (initiators) photopolymerization system is presented for both numerical solutions and analytic formulas. The dynamic profiles are simulated for oxygen, free radical, and conversion for various concentrations of the co-initiator. The measured system reported by Kirschner et al. showed that conversion could be improved...
Article
This paper presents the original design of a set of coumarin derivatives (CoumC1-CoumC13). First, these structures were in-silico designed by molecular modelling to ensure both excellent light absorption properties and high potential photoreactivity (high excited state energy). As a striking result of this in-silico design, 8 of the 13 proposed cou...
Article
Full-text available
For the first time, this study presents the detailed kinetics, and modeling the conversion efficacy associated with the experimental results of Bonardi et al. The dual function of the enhancer additive includes: (i) regenerating the photoinitiator, and (ii) producing extra reactive radical. The temporal profiles of the concentration of each of the...
Article
Full-text available
Detailed kinetics for a 3-wavelength photopolymerization confinement (PC) system is presented for both numerical solutions and analytic formulas. The dynamic profiles of oxygen, free radicals, and monomer conversion for various situations of: blue-light only, 2-light (red and UV), and 3-light (red, blue, UV) are obtained. Higher oxygen concentratio...
Article
A novel strategy for red‐light‐controlled oxygen inhibition for improved UV‐light‐initiated monomer conversion is theoretically presented for the first time. The dual‐wavelength kinetic equations are derived, numerically and analytically solved for the oxygen and photoinitiator concentration profiles. The UV‐light‐initiated Type I conversion effica...
Chapter
The dynamic roles of photosensitizer (PS) concentration and light intensity were measured and analyzed. The efficacy of photodynamic therapy (PDT) and cell viability (CV) are measured (in vitro) and analyzed by analytic and numerical modeling. For a fixed PS concentration, CV is a nonlinear deceasing function of light intensity and exposure time; f...
Article
Full-text available
Kinetic equations for a modeling system with type-I radical-mediated and type-II oxygen-mediated pathways are derived and numerically solved for the photopolymerization efficacy and curing depth, under the quasi-steady state assumption, and bimolecular termination. We show that photopolymerization efficacy is an increasing function of photosensitiz...
Article
Full-text available
The kinetics and modeling of dual-wavelength (UV and blue) controlled photopolymerization confinement (PC) are presented and measured data are analyzed by analytic formulas and numerical data. The UV-light initiated inhibition effect is strongly monomer-dependent due to different C=C bond rate constants and conversion efficacies. Without the UV-lig...
Preprint
Detailed kinetics for a 3-wavelength photopolymerization confinement (PC) system is presented for both numerical solutions and analytic formulas. The dynamic profiles are simulated for oxygen, free radical, and conversion for various situations of: blue-light only, 2-light (red and UV), and 3-light (red, blue, UV). An effective PC requires two cond...
Preprint
The kinetics and modeling of dual-wavelength controlled photopolymerization confinement (PC) are presented and measured data are analyzed by analytic formulas and numerical data. The UV-light initiated inhibition effect is strongly monomer-dependent and different monomers have different C=C bond rate constants and conversion efficacy. Without the U...
Article
Full-text available
Kinetics and analytical formulas for radical-mediated thiol-ene photopolymerization were developed in this paper. The conversion efficacy of thiol-ene systems was studied for various propagation to chain transfer kinetic rate-ratio (RK), and thiol-ene concentration molar-ratio (RC). Numerical data were analyzed using analytical formulas and compare...
Article
Full-text available
The multiple regression formulas and correlation of ocular components with refractive errors are presented by Gaussian optics. The refractive error changing rate for the cornea and lens power, the axial length, anterior chamber depth (ACD) and vitreous chamber depth (VCD) are calculated, including nonlinear terms for more accurate rate functions th...
Article
Full-text available
Optimal conditions for maximum efficacy of photoinitiated polymerization are theoretically presented. Analytic formulas are shown for the crosslink time, crosslink depth, and efficacy function. The roles of photoinitiator (PI) concentration, diffusion depth, and light intensity on the polymerization spatial and temporal profiles are presented for b...
Preprint
Optimal conditions for maximum efficacy of photoinitiated polymerization are theoretically presented. Analytic formulas are shown for the crosslink time, crosslink depth and efficacy function. The roles of photoinitiator (PI) concentration, diffusion depth and light intensity on the polymerization spatial and temporal profiles, for both uniform and...
Preprint
The kinetics and efficacy profiles of photoinitiated polymerization are theoretically presented. For the same dose, lower light intensity achieves a higher steady-state-efficacy (SSE) in type-I; in contrast, type-II has an equal SSE. Higher light intensity has a faster rising efficacy, due to faster depletion of photoinitiator (PS) concentration. H...
Preprint
The kinetics and optimal efficacy conditions of photoinitiated polymerization are theoretically presented. Analytic formulas are derived for the crosslink time, crosslink depth and efficacy function. The roles of photosensitizer (PS) concentration, diffusion depth and light intensity on the polymerization spatial and temporal profiles, for both uni...
Article
Full-text available
Aim: To analyze the clinical factors influencing the human vision corrections via the changing of ocular components of human eye in various applications; and to analyze refractive state via a new effective axial length. Methods: An effective eye model was introduced by the ocular components of human eye including refractive indexes, surface radi...
Article
Full-text available
Objective Analysis of the crosslink time, depth and efficacy profiles of UV-light-activated corneal collagen crosslinking (CXL). Methods A modeling system described by a coupled dynamic equations are numerically solved and analytic formulas are derived for the crosslinking time (T*) and crosslinking depth (z*). The z-dependence of the CXL efficacy...
Article
Aim: To analyze the efficacy of ultraviolet (UV) light initiating corneal cross-linking (CXL). Methods: The time-dependent absorption of UV light due to the depletion of the initiator (riboflavin) was calculated. The effective dose of CXL with corneal surface covered by a thin layer of riboflavin was derived analytically. The cross linking time...
Article
The kinetics of UV light photoinitiated polymerization system (PPS) with non-uniform initiator concentration is theoretically presented. Analytic formulas are derived for the cross linking time (T*), defined by the depletion level of the initiator, which is an exponentially increasing function of the thickness, whereas it is inverse proportional to...
Article
Full-text available
This study explored the kinetics of ultraviolet (UV) laser photoinitiated polymerization in thick polymer systems to achieve improved polymerization efficiency and uniformity. The modeling system comprised an incident UV laser and its reflecting beam, which was focused by a concave mirror to compensate for the exponential decay in the absorbing med...
Article
The kinetics of near infrared (NIR) laser photothermal initiated and ultraviolet (UV) laser photoinitiated polymerization in thick polymer systems was theoretically presented. A uniform initiator concentration profile as time evolves can be obtained by combining two mechanisms, i.e., the photoinitiation and photothermal initiation. The photoinitiat...
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Full-text available
We present a modeling study of photoinitiated polymerization in a thick polymer-absorbing medium using a focused UV laser. Transient profiles of the initiator concentration at various focusing conditions are analyzed to define the polymerization boundary. Furthermore, we demonstrate the optimal focusing conditions that yield more uniform polymeriza...
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Full-text available
This study proposes a fast 3D dynamic programming expansion to find a shortest surface in a 3D matrix. This algorithm can detect boundaries in an image sequence. Using phantom image studies with added uniform distributed noise from different SNRs, the unsigned error of this proposed method is investigated. Comparing the automated results to the gol...
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Full-text available
This paper presents a normalized transmitted signal (NTS) of a fiber-based sensor using gold nanorods as the plasmon excitation medium of the evanescent wave. The NTS and the refractive index (RI) sensitivity is calculated as a function of the gold aspect ratio (R), the RI of the sensing medium, and a scaling parameter given by the ratio of the fib...
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We present a novel pulsed-train near-IR diode laser system with real-time temperature monitoring of the laser-heated cancer cell mixed in gold nanorod solution. Near-IR diode laser at 808 nm matching the gold nanorod absorption peak (with an aspect ratio about 4.0) was used in this study. Both surface and volume temperatures were measured and kept...
Article
A nonlinear theory for the optical properties of gold nanorods at various aspect ratios is used to calculate the refractive index sensitivity of surface plasmon resonance (M) which is found to be 100 to 1000 nm/RIU and proportional to the aspect ratio (R). Based on Gans theory, the calculated figure of merit, defined by the ratio of M and the reson...
Article
Full-text available
Analysis and applications of vision correction via accommodating intraocular lens (AIOL) are presented. By Gaussian optics, analytic formulas for the accommodation rate function (M) for two-optics and three-optics systems are derived and compared with the exact numerical results. In a single-optics AIOL, typical value of M is (0.5-1.5) D∕mm, for an...
Article
Analytic formulas for spherical nanoshell (Au/silica) resonance wavelength and refractive index sensitivity were derived and compared with a numerical nonlinear theory. A universal scaling law was deduced in terms of a normalized thickness defined by the ratio of the shell thickness and its core diameter. The calculated figure of merit shows a maxi...
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Full-text available
We describe a color image reconstruction method that enables both direct visualization and direct digital image acquisition from one oral tissue by using various light sources and color compensating filters. In this method, the image of the oral tissue with white light emitting diodes (LEDs) with blue color compensating filter has a larger color di...
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Full-text available
This study evaluated the effectiveness of near-infrared laser-excited gold nanorods as the active target to selectively kill the cancer cells. The key parameters of laser and sample to be measured include the absorption coefficient, the laser fluence and irradiation time, and the temperature profiles. The optimal laser operation for the surface and...
Article
Full-text available
A nonlinear theory for the optical properties of gold nanorods is presented. The refractive index sensitivity of the associated surface plasmon resonance is calculated to be 100-1000 nm/RIU for the aspect ratio range of 1-10. According to Gan's theory, the figure of merit, defined by the refractive index sensitivity divided by the FWHM value of the...

Citations

... Intensive research with regard to modeling the curing kinetics and deriving analytical relationships between curing depth and crosslink time, as well as considering the effects of oxygen inhibition and viscosity was conducted by Lin and his co-authors [30,[112][113][114][115][116][117]. For instance, in 2016 Lin et al. [112] proposed a comprehensive mechanistic model for the cure kinetics of photopolymerization in optically thick polymers, providing useful guidance for the parameters selection and optimization for predicting the curing time for various polymer thicknesses in photoinitiated polymerization systems. ...
... Bonardi et al [21] reported high performance near-Infrared photoinitiating systems in the presence of oxygen. Tar et al [22] reported the novel copper photoredox polymerization for in situ synthesis of metal nanoparticles, and was analyzed by modeling of Lin et al [23]. More recently Mau et al [24] reported the panchromatic (using 455 nm and 530 nm visible LED) of copper complexes photopolymerization. ...
... In the past 18 years (2003-2020], over 1,000 articles were published on the clinical aspects of CXL. In comparison, only about 20 articles were published regarding the basic kinetics and/or the theory of CXL , in which over 75% was published by Lin et al. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. With the lack of indepth fundamental studies and lack of conclusive theoretical predictions, the following controversial (clinical/theoretical) issues remained to be resolved [15,22]: ...
... However, the actual value of dR (and AG) requires accurate data for the distance of BC and CD in Fig. 3; and the relation of the amount of sclera tissue (AST) removed (or shrinkage) and dc (or dR). Based on the reported clinical outcomes of Lin et al. [23,24], Xu et al. [25]. Kaiti et al [26] and Hipsley et al. [27,28], we found out that the efficacy of LASA (or AG) is mainly governed by AST, and insensitive to the ablation patterns (either lines or dots). ...
... According to Lin et al. [30], oxygen inhibition plays a critical role, especially for optically thin polymers. However, various strategies to reduce oxygen inhibition in photopolymerizations are proposed in the literature [31,32]: (1) using a higher light dose or intensity, (2) using a higher photoinitiator concentration, (3) using co-initiators, (4) addition of radical scavengers, (5) working in an inert environment, and (5) chemical mechanisms such as the thiol-ene and thiol-acrylate-Michel systems which are insensitive to oxygen. ...
... [35] Face to these considerations, polymerization of thick samples and even of resins containing fillers can be achieved. Reprinted with permission from Bonardi et al. [35] Considering that the light penetration is the key parameter for achieving high monomer conversions, a wide range of structures have been examined ranging from truxene derivatives [36] to copper complexes, [37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53] carbazoles, [54][55][56][57][58][59][60][61][62][63][64][65] chalcones, [28,[66][67][68][69][70][71][72][73][74][75][76][77][78] zinc complexes, [79] acridones, [80,81] iridium complexes, [82][83][84][85][86][87][88][89] cyanines [90][91][92][93][94][95] phenazines, [96] push-pull dyes, [97][98][99][100][101][102][103][104][105][106][107][108][109][110][111] anthracene, [112] porphyrins, [113,114] triphenylamines, [115] thioxanthones, [116][117][118][119][120][121][122][123][124][125][126][127][128] dihydro-anthraquinones, [129] metal organic framework (MOFs), [130][131][132] diketopyrrolopyrroles, [133][134][135] pyrenes, [136][137][138][139][140][141][142][143][144] perovskites, [145,146] acridine-1,8-diones. [147][148][149] perylenes, [150][151][152][153] dithienophospholes, [154,155] iodonium salts, [156][157][158][159][160][161][162][163] iron complexes, [97,131,[164][165][166][167][168][169] helicenes, [170,171] pyrrole derivatives, [172] 2,3-diphenylquinoxaline derivatives, [173,174] thiophene derivatives, [175] polyoxometalates, [176][177][178] camphorquinones, [179,180] phenothiazines, [181] Schiff bases, [182] coumarins, [183][184][185][186][187][188][189][190][191][192][193][194] naphthalimides, [156,[195][196][197][198][199][200][201][202][203][204][205][206][207][208][209][210][211] chromones and flavones, [212][213][214] curcumin, [215][216][217][218] squaraines, [219][220][221][222] benzophenones, [223][224][225][226][227][228][229][230] conjugated polymers, [231] and cyclohexanones. [232][233][234][235] If these structures could enable to develop highly efficient photoinitiating systems, high monomer conversions could only be obtained by using multicomponent systems, resulting in complex formulations. ...
... Besides the enhancement effects discussed in the present article using an additive of CTC, there are many other strategies that have been reported by our group, including the use of multi-wavelength light and strategies of reduction the oxygen inhibition [24][25][26][27][28]. A critical review of photopolymerization for 3D bioprinting can be found in [24]. ...
... (1) 0.2% C21 + 1% Iod; (2) 0.2% C23 + 1% Iod + 1% NPG; (3) 0.2% C24 + 1% Iod + 1% NPG; (4) 0.2% C26 + 1% Iod + 1% NPG; (5) 0.2% C28 + 1% Iod + 1% NPG; (6) 0.2% C29 + 1% Iod + 1% NPG; and (7) 0.2% C31 + 1% Iod + 1% NPG, respectively. Reprinted with permission from Abdallah et al. [208] While getting a deeper insight into the photochemical mechanism, steady-state photolysis experiments done with C22 as a model compound revealed C22 to be photostable upon irradiation at 375 nm in an acetonitrile solution. Conversely, upon addition of the iodonium salt, a rapid decrease of the optical density at the absorption maximum could be detected, with the appearance of a new peak corresponding to a photoproduct (See Figure 14). ...
... Both spatial and temporal controlled 3D processes were reported in systems using single and multiple wavelength lights [5,6]. We have previously reported various strategies for improved photopolymerization conversion, in which the efficacy enhancement is achieved by co-initiators and co-additives in multiple components systems [7][8][9][10][11]. ...
... Intensive research with regard to modeling the curing kinetics and deriving analytical relationships between curing depth and crosslink time, as well as considering the effects of oxygen inhibition and viscosity was conducted by Lin and his co-authors [30,[112][113][114][115][116][117]. For instance, in 2016 Lin et al. [112] proposed a comprehensive mechanistic model for the cure kinetics of photopolymerization in optically thick polymers, providing useful guidance for the parameters selection and optimization for predicting the curing time for various polymer thicknesses in photoinitiated polymerization systems. ...