Jürgen Becker's research while affiliated with Universitätsklinikum Düsseldorf and other places
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Publications (164)
Objectives:
Long-term follow-up observations of zirconia implants are rare. This study aimed at evaluating the clinical performance of two-piece zirconia implants in the posterior jaws over 9 years.
Materials and methods:
Sixty partially edentulous patients were treated with two-piece zirconia implants. In eight no primary stability could be ach...
Background
To evaluate peri-implant tissue dimensions following implantoplasty and/or regenerative therapy of advanced ligature-induced peri-implantitis in dogs.
Material and methods
At all defect sites ( n = 6 dogs, n = 48 implants), the intrabony component was filled with a particulate bovine-derived natural bone mineral (NBM). The supracrestal...
Background
The aim of the current study was the evaluation of initial biofilm adhesion and development on laser-microtextured implant collar surfaces and the examination of effectivity of different biofilm management methods.
Methods
Initial biofilm formation was investigated on hydrophobic machined and laser-microtextured (Laser-Lok) titanium sur...
Objectives:
To assess the clinical performance of an equine-derived collagen-containing bone block (CXBB) for lateral alveolar ridge augmentation and staged implant placement.
Material and methods:
A total of n = 16 patients (16 implants) had received a modified surgical protocol for lateral ridge augmentation using a size-adapted rigidly fixed...
Objectives:
The purpose of the present survey is to give an update of European experts' opinion on infection control and prevention in dentistry during second wave of pandemic. The secondary aim was to analyse how experts' opinion changed in the light of the new scientific evidence since the first wave.
Material & methods:
An anonymous online 14...
COVER ILLUSTRATION: The cover image is based on the Original Article Assessment of soft and hard tissue dimensions following different treatment approaches of ligature‐induced peri‐implantitis defects by Ausra Ramanauskaite et al., https://doi.org/10.1111/clr.13709.
Objectives
To assess the long-term clinical outcomes following lateral alveolar ridge augmentation using a collagenated xenogeneic bone block (CXBB) and staged implant placement.
Material and methods
A total of n = 9 patients (9 implants) were available for the analysis. Each subject had received lateral ridge augmentation using a size-adapted rig...
Objectives
To evaluate peri‐implant tissue dimensions following non‐surgical (NS) and surgical therapy (S) employing different decontamination protocols of advanced ligature‐induced peri‐implantitis in dogs.
Material & Methods
Peri‐implantitis defects (n=5 dogs, n=30 implants) were randomly and equally allocated in a split‐mouth design to NS or S...
Objectives
The current COVID‐19 outbreak in conjunction with the need to provide safe dental treatments and the limited knowledge on the efficacy of protective measures has posed dentists into a challenging situation. Therefore, the present article aimed at collecting experiences and recommendations of frontline clinical experts on critical aspects...
Objectives
To assess the short‐term clinical outcomes of lateral augmentation of deficient extraction sockets and two‐stage implant placement using autogenous tooth roots (TR).
Material & Methods
A total of n=13 patients (13 implants) were available for the analysis.
At the time of tooth extraction, each subject had received lateral augmentation u...
Background
To assess the influence of ridge preservation procedures on the healing of extraction sockets under antiresorptive therapy.
Material and Methods
A total of 10 Dutch Belted rabbits were randomly allocated to either the intravenous administration of amino‐bisphosphonate (zoledronic acid) (Za) (n = 5) or a negative control group (no Za [nZ...
Background:
To assess the effects of differently sized titanium (Ti) and zirconia (Zr) particles on (1) the metabolic activity of osteosarcoma-derived osteoblasts (SaOs-2) and human gingival fibroblasts (HGF) and (2) the cytokine expression of monocytes (THP-1) METHODS: Ti (60-80 nm and 100 nm) and Zr (2 μm and 75 μm) particles were incubated with...
Damage to the critical anatomic structures during dental implant placement can lead to serious complications, including intra‐ or postoperative bleeding, hematoma formation, or varying degrees of neurosensory alteration. These complications usually occur when the anatomic features of the major blood vessels and their anastomoses, neurovascular bund...
Objectives:
To assess the short-term clinical outcomes of lateral alveolar ridge augmentation using autogenous tooth roots (TR) and autogenous bone blocks (AB).
Material & methods:
A total of n=23 patients (23 implants) were available for the analysis. Each subject was allocated to lateral ridge augmentation using either 1) healthy autogenous to...
After removal of a dental implant or extraction of a tooth in the upper jaw, the closure of an oroantral fistula (OAF) or oroantral communication (OAC) can be a difficult problem confronting the dentist and surgeon working in the oral and maxillofacial region. Oroantral communication (OAC) acts as a pathological pathway for bacteria and can cause i...
Objectives
To assess the feasibility of using autogenous tooth roots (TR) for a lateral augmentation of deficient extraction sockets and two‐stage implant placement.
Material and Methods
A total of 15 patients were recruited to perform a simultaneous, lateral augmentation of deficient (i.e., thickness of the buccal bone < 0.5 mm or buccal dehiscen...
Background:
To assess and compare the radiographic outcomes following lateral alveolar ridge augmentation using autogenous tooth roots (TR) and autogenous bone (AB) blocks.
Methods:
In a total of 30 patients, lateral ridge augmentation was conducted in parallel groups using either (1) healthy autogenous tooth roots (e.g., retained wisdom or impa...
Abstract An oroantral fistula (OAF) is a pathological abnormal communication between the oral cavity and the maxillary sinus which may arise as a result of failure of primary healing of an OAF, dental infections, osteomyelitis, radiation therapy, trauma, or iatrogenic complications. With the presence of a fistula, the maxillary sinus is permanently...
Objectives
To assess and compare the efficacy and safety of autogenous tooth roots (TR) and autogenous bone blocks (AB) for lateral alveolar ridge augmentation and two‐stage implant placement.
Material & Methods
A total of 30 patients in need of implant therapy and lateral ridge augmentation were allocated to parallel groups receiving either 1) he...
Objectives
To analyze the influence of the width of keratinized mucosa (KM) on the development and resolution of experimental peri‐implant mucositis lesions at abutments with different microstructures in humans.
Material and methods
In a randomized, controlled study, a total of 28 patients had received 28 target implants exhibiting a KM ≥2 mm. The...
Objectives:
To assess the onset, progression and resolution of experimentally induced peri-implant mucositis lesions at abutments with different microstructures in humans.
Material & methods:
In a randomized, controlled, interventional two-center study, a total of 28 patients had received 28 target implants and were randomly allocated to either...
Objectives
The objective of the study was to assess the influence of implantoplasty (IP) on the diameter, chemical surface composition, and biocompatibility of titanium implants in vitro. Material and methodsTwenty soft tissue-level (TL; machined transmucosal—M and rough endosseous part—SLA) and 20 bone-level (BL; SLA) implants were allocated to IP...
Objectives:
To assess the long-term clinical outcomes following nonsurgical therapy of peri-implant diseases at two-piece zirconium implants.
Material & methods:
A total of 27 patients suffering from either (i) peri-implant mucositis (n=24 implants) or (ii) peri-implantitis (n=16 implants) completed a mean follow-up period of 32.8±2.85 months (m...
Objectives
This study seeks to assess the bone tissue response at experimental zirconia implants in comparison with titanium implants by means of descriptive histology and histomorphometry in a dog model.
Materials and methods
Experimental zirconia implants with three different surface roughnesses (Z1 < Z2 < Z3) and conventional sandblasted large g...
Objectives:
To assess the long-term outcomes (>4 years) following combined surgical resective/regenerative therapy of advanced peri-implantitis lesions using two surface decontamination methods.
Material & methods:
Fifteen patients (n = 15 combined supra- and intrabony defects) completed a follow-up observation period of 7 years. The treatment p...
The cover image, by Ilja Mihatovic et al., is based on the Animal Experiment Periodontally diseased tooth roots used for lateral alveolar ridge augmentation. A proof-of-concept study, DOI: 10.1111/jcpe.12579.
Objectives:
To assess the clinical safety and performance of collagenated xenogeneic bone block (CXBB) for lateral alveolar ridge augmentation and two-stage implant placement.
Material & methods:
In ten patients exhibiting a single-tooth gap, the surgical procedure included the preparation of mucoperiosteal flaps, a rigid fixation of CXBB (Geist...
Eine frühzeitige und vor allem umfassende Diagnostik bildet die Grundlage der systematischen parodontalen Therapie. Das Buch stellt alle Bereiche der zeitgemäßen parodontalen Diagnostik dar und bietet damit allen parodontologisch tätigen Zahnärzten, angehenden Parodontologen und Dentalhygienikerinnen einen Überblick.
Ausgehend von der Erfassung de...
Objectives:
Recent animal studies have indicated, that tooth roots reveal a structural and biological potential to serve as alternative autografts for localized ridge augmentation. This proof-of-concept initial report aimed at investigating, whether this new surgical concept may be applied to humans.
Material & methods:
In one patient, who was i...
Objectives:
To assess the efficacy of periodontally diseased tooth roots used as autografts for lateral ridge augmentation and two-stage early osseointegration of titanium implants.
Material & methods:
Ligature-induced periodontitis lesions were established at the maxillary premolars in n=8 foxhounds. Extracted, scaled and root planned premolar...
Objectives:
To assess the clinical outcomes of simultaneous guided bone regeneration using native (CM) and cross-linked (VN) collagen membranes at 8 years.
Materials and methods:
A total of n = 19 patients (19 implants) were available for the analysis. Each subject had received a simultaneous grafting of dehiscence-type defects using a natural b...
Objectives:
The aim of the current study was the evaluation of biofilm development on different implant surfaces.
Material and methods:
Initial biofilm formation was investigated on five different implant surfaces, machined titanium (MTi), modified machined acid-etched titanium (modMATi), machined titanium zirconium (MTiZr), modified machined an...
In patients with peri-implant mucositis and peri-implantitis, what is the efficacy of nonsurgical (i.e. referring to peri-implant mucositis and peri-implantitis) and surgical (i.e. referring to peri-implantitis) treatments with alternative or adjunctive measures on changing signs of inflammation compared with conventional nonsurgical (i.e. mechanic...
Objectives:
To assess the efficacy of tooth roots used as autografts for lateral ridge augmentation and two-stage early osseointegration of titanium implants.
Material & methods:
The maxillary premolars were randomly assigned to either endondontic therapy (PM-E) or were left untreated (PM-C). Retromolar cortical autogenous bone (AB) blocks serve...
This retrospective analysis of five reentry cases reports on the clinical defect healing after combined surgical resective/regenerative therapy of advanced peri-implantitis. A second surgery was necessary because of a clinical need for additional treatment procedures at the respective implant sites after healing periods of 8 months to 6.5 years. Al...
The purpose of the present study was the evaluation of effectiveness and efficiency of a powder consisting of glycine and tricalcium phosphate in comparison to two established powders based on glycine or sodium bicarbonate in biofilm removal on titanium and zirconium implant surfaces.
Biofilm was collected for 48 h by five volunteers. A total of 69...
To assess the efficacy of nonsurgical therapy for the management of peri-implant diseases at a two-piece zirconium implant system.
34 patients with 45 implants participated in this study. 17 patients (24 implants) were diagnosed with peri-implant mucositis and received mechanical debridement + local antiseptic therapy using chlorhexidine digluconat...
To assess the prevalence of peri-implant health or disease for a two-piece implant system with a tube-in-tube internal connection on the short-, medium- and long term.
For this cross-sectional analysis, 238 patients with a total of n = 512 implants were screened in six private practices and one university clinic in Germany. Peri-implant health and...
The treatment of infectious diseases affecting osseointegrated implants in function has become a demanding issue in implant dentistry. Since the early 1990s, preclinical data from animal studies have provided important insights into the etiology, pathogenesis and therapy of peri-implant diseases. Established lesions in animals have shown many featu...
To assess the clinical performance of two-piece zirconium implants over a period of up to 2 years.
A total of 52 patients with single-tooth gaps in the posterior mandible or maxilla received the same type of a two-piece zirconium implant system with customized heights of the transmucosal aspect. Fibreglass abutments were cemented and restored with...
Objectives:
The aim of the present study was the evaluation of the effectiveness and efficiency of two plaque-removing techniques, plastic curettes (PC) and glycine powder airflow (GLY) in combination with taurolidine (T), chlorhexidine (CHX), or pure water (PW) as additives and compared to groups without previous treatment (NT).
Materials and me...
Objectives
To assess the impact of microgrooved abutments and the insertion depth on crestal bone changes at titanium implants with platform switch.Materials and MethodsA total of n = 3 titanium implants (conical abutment connection) were inserted in each hemimandible of n = 6 foxhounds with the implant shoulder (IS) located at either epicrestal, s...
This case report presents a 3-year follow-up of the clinical outcomes of a combined surgical therapy for advanced peri-implantitis with concomitant soft tissue volume augmentation using a collagen matrix. One patient suffering from advanced peri-implantitis and a thin mucosal biotype underwent access flap surgery, implantoplasty at buccally and sup...
Objectives
To evaluate the impact of plaque accumulation on osseointegration at surface enhanced modified hydrophilic titanium–zirconium (TiZr) alloy and titanium (Ti) implants.Materials and methodsTiZr and Ti implants with a sand-blasted, acid etched, and chemically modified endosseous and a machined (M) transmucosal portion were bilaterally (i.e....
The atrophic alveolar ridge in the posterior mandible remains a challenge for an implant-supported prosthetic rehabilitation due to the location of the inferior alveolar nerve. To ensure implants are placed within bone of sufficient dimension, vertical ridge augmentation is frequently necessary. The presented case discusses an extensive alveolar ri...
Purpose:
The purpose of the study was the evaluation of possible cytologic effects of taurolidine to fibroblasts and osteoblast-like cells.
Materials and methods:
Human gingival fibroblasts and SaOS-2 cells were seeded on samples with sand-blasted and acid-etched surfaces. Both groups were treated with taurolidine, chlorhexidine, and pure water...
To histologically and immunologically assess experimental peri-implant mucositis at surface enhanced modified (mod) hydrophilic titanium implants.
In a split-mouth design (n=6 foxhounds), 4 different implants were inserted on each side of the maxilla: 3 titanium-zirconium alloy implants (TiZr) with either modSLA (sand-blasted, acid etched and chemi...
Objectives:
To histologically assess the effectiveness of a porcine-derived collagen matrix (CM) and a subepithelial connective tissue graft (CTG) for the coverage of single mucosal recessions at osseointegrated dental implants.
Materials and methods:
Chronic-type mucosal Miller Class I-like recessions (mean clinical defect height: 0.67 ± 0.33-1...
This study seeks to assess and compare immunohistochemical characteristics of regenerated and pristine bone areas following surgical therapy of advanced peri-implantitis.
At ligature-induced peri-implantitis defects, the intrabony component was filled with a natural bone mineral (NBM), and the supracrestal component was treated by either an equine...
Peri-implant mucositis and peri-implantitis are a raising issue in dental implantology. Peri-implant infections are mainly caused by the formation of biofilm. Different surface textures exhibit various conditions for biofilm formation resulting in several speed of maturation and development.
On three different titanium implant surfaces, machined-su...
To investigate the impact of two surface decontamination methods on the long-term outcomes following combined surgical resective/regenerative therapy of advanced peri-implantitis lesions.
Seventeen patients (n = 17 combined supra- and intrabony-defects) completed the 48 months follow-up observation following access flap surgery, granulation tissue...
To investigate the impact of a cross-linked- (VN) collagen membrane on the long-term stability of peri-implant health over 6 years.
Vestibular dehiscence-type defects at titanium implants (19 patients, 19 implants) were augmented using a natural bone mineral and randomly allocated to either VN or a native collagen membrane (CM) and left to heal in...
Aim:
The aim of the present study was to investigate the impact of proangiogenic factors [erythropoetin (EPO), human growth hormone (HGH), fibroblast growth factor (FGF), and platelet derived growth factor (PDGF-BB)] on the organization and biodegradation of a porcine-derived collagen matrix (CM) in rats.
Material and methods:
Collagen matrix sp...
Objectives
To address the following focused question: What is the impact of implant–abutment configuration and the positioning of the machined collar/microgap on crestal bone level changes?
Material and methods
Electronic databases of the PubMed and the Web of Knowledge were searched for animal and human studies reporting on histological/radiologi...
Objectives:
This study aimed to immunohistochemically evaluate staged guided bone regeneration and osseointegration of titanium implants using two bone graft substitutes in combination with a polyethylene glycol (PEG) membrane in a dog model.
Materials and methods:
Saddle-type alveolar ridge defects were prepared in the lower jaws of 12 foxhound...
To histologically evaluate and compare the performance of healing abutments with either hydrophobic or hydrophilic surface properties in humans.
According to a parallel-group design, titanium implants placed in the posterior mandible and maxilla of 30 patients were randomly assigned to either (1) hydrophobic machined (M), (2) chemically modified hy...
Aim:
The aim of the present study was to evaluate bone formation in vertical ridge augmentations using particulate bone grafting material stabilized by a resorbable polymer.
Material and methods:
Three vertical defects were created in the maxillary alveolar ridge of six Beagle dogs 3 months after the removal of all premolars. One defect in each...
Objectives:
The purpose of this study was the evaluation of the effectiveness of plaque removing of a new rotating brush made of titanium in comparison with the cleaning procedure with steel curettes.
Materials and methods:
Plaque was collected by six volunteers for 48 h. A total of 60 samples were randomly designated to two groups: the test gro...
Objectives:
Mucosal recessions are a common finding following surgical treatment of peri-implantitis, thus compromising the overall esthetic outcome of implant therapy. This case series aimed at evaluating the clinical outcome of a combined surgical therapy of advanced peri-implantitis lesions with concomitant soft tissue volume augmentation.
Mat...
Objectives
To assess the safety and efficacy of a rigid synthetic barrier system in a shell technique for localized alveolar ridge augmentation. Materials and methodsSaddle-type defects (n=4 each) were prepared in the lower jaws of six fox hounds. At two defects, the outer contours were reconstructed using polylactic acid (D and L isomers) (PDDL) p...
Purpose:
This case illustrates a pulp tissue-induced dentointegration of a titanium implant.
Materials and methods:
One commercially available titanium implant with a sand-blasted and acid-etched surface was placed in the maxilla of a foxhound where the palatinal root of the previously (i.e., 8 weeks) removed first molar was unintentionally reta...
Objectives
The aim of this study was to evaluate the accuracy of measuring bone thickness surrounding dental implants and the reliability of assessing existence and completion of osseous integration of augmentation material using a cone beam computed tomography (CBCT) system.
Materials and methods
In jaws of foxhounds, artificial defects were regen...
Purpose
This is a pilot study which aims to evaluate the accuracy of cone-beam computed tomography (CBCT) to assess the configuration and extent of ligature-induced peri-implantitis defects.
Materials and methods
Radiographic evaluation of advanced ligature-induced peri-implantitis defects (n = 9) in canine was performed using CBCT (central cross-s...
The study aimed at evaluating the 2-year results obtained following combined surgical resective and regenerative treatment of advanced peri-implantitis defects comparing two methods of surface debridement/decontamination (DD).
Twenty-four patients (n = 26 combined supra- and intrabony defects) completed the 24 months follow-up observation following...
To address the following focused question: What is the quality of reporting of pre-clinical research for the study and treatment of mucositis/peri-implantitis?
Electronic databases of the PubMed and the Cochrane Library were searched for animal studies reporting on pathogenesis or therapy of either peri-implant mucositits or peri-implantitis and co...
To evaluate cone beam computed tomography (CBCT) for monitoring of tibial bone defect healing in comparison to histopathological findings.
Circumscribed tibial bone defects were created in 16 mini-pigs and imaging of the tibia was performed on day 42 using a modern CBCT scanner with flat panel detector (PaX-Duo3D, Vatech, Korea). The extent of osse...
To evaluate radiological bone level (RBL) (i.e. cone-beam computed tomography) and histological bone levels (HBL) as well as re-osseointegration [bone-to-implant contact (BIC)] after surgical resective (i.e. implantoplasty) and/or regenerative therapy of advanced ligature-induced peri-implantitis in dogs.
At all defect sites (n=6 dogs, n=48 implant...
To assess the influence of two barrier membranes and two bone graft substitutes on staged guided bone regeneration and osseointegration of titanium implants in dogs.
Saddle-type defects were prepared in the lower jaws of 6 fox hounds and randomly filled with a natural bone mineral (NBM) and a biphasic calcium phosphate (SBC) and allocated to either...
The aim of this prospective, parallel group designed, randomized controlled clinical study was to evaluate the effectiveness of an air-abrasive device (AAD) for non-surgical treatment of peri-implantitis.
Thirty patients, each of whom displayed at least one implant with initial to moderate peri-implantitis, were enrolled in an oral hygiene program...
To investigate the impact of residual defect height (RDH) following guided bone regeneration (GBR) in dehiscence-type defects on the long-term stability of peri-implant health after a period of 4 years.
The RDH values in dehiscence-type defects at titanium implants were clinically assessed after 4 months of submerged healing following augmentation...
The aim of this prospective, multicenter, randomized clinical trial was to evaluate histologically the outcome of maxillary sinus lift augmentation with a recombinant human growth and differentiation factor-5-coated β-tricalcium phosphate (rhGDF-5/β-TCP) or with a β-TCP and autogenous bone (β-TCP/AB) composite.
Thirty-one patients requiring unilate...
To assess the accuracy of cone-beam computed tomography (CBCT) in terms of buccal bone-wall configuration and peri-implant bone defect regeneration after guided bone regeneration (GBR).
Titanium implants were inserted into standardized box-shaped defects in the mandible of 12 foxhounds. Defects of one side were augmented following the principle of...
Concerning pen-implant infections, a general differentiation is done between mucositis which is limited to the pen-implant soft tissue and peri-implantatis, which also affects the surrounding bone. To avoid pen-implant infections, a subsequent analysis and prevention of risk factors is a special need. From the actual literature it can be concluded...
To assess the influence of two barrier membranes and two bone graft substitutes mixed with autogenous bone (AB) on staged guided bone regeneration and osseointegration of titanium implants in dogs.
Four saddle-type defects each were prepared in the upper jaw of six fox hounds and randomly filled with a natural bone mineral (NBM)+AB and a biphasic c...
The study aimed at investigating the impact of two surface debridement/decontamination (DD) methods on the clinical outcomes of combined surgical treatment of peri-implantitis.
Thirty-two patients suffering from advanced peri-implantitis (n=38 combined supra- and intra-bony defects) were treated with flap surgery, granulation tissue removal, and im...
The aim of this prospective, randomized clinical trial was to investigate the potential of recombinant human growth and differentiation factor-5 (rhGDF-5) coated onto β-tricalcium phosphate (β-TCP) (rhGDF-5/β-TCP) to support bone formation after sinus lift augmentation.
In total, 31 patients participated in this multicenter clinical trial. They req...
The role of platelet-rich plasma (PRP) as a promoter of bone healing remains controversial. The aim of this study was to investigate the effect of PRP in combination with calcium phosphate granules (CPG) on bone defect healing in a metaphyseal long bone defect. A metaphyseal bone defect at the proximal tibia of 16 mini-pigs was filled with CPG comb...
The aim of the present study was to histologically evaluate and compare a new prototype collagen type I/III-containing equine- (EB) and a bovine- (BB) derived cancellous bone block in a dog model.
Four standardized box-shaped defects were bilaterally created at the buccal aspect of the alveolar ridge in the lower jaws of five beagle dogs and random...
To investigate (i) the impact of different titanium implant surfaces on soft tissue integration over 6 months, and (ii) the influence of frequent clinical probing during the healing phase on the established mucosal seal.
Standardized clinical probing was randomly performed (12 dogs, probing versus control) at different transmucosal surfaces [machin...
The aim of the present study was to compare bone regeneration in dehiscence-type defects at titanium implants with chemically modified sandblasted/acid-etched (modSLA) or dual acid-etched surfaces with a calcium phosphate nanometre particle modification (DCD/CaP).
Buccal dehiscence-type defects were surgically created following implant site prepara...
The aim of the present study was to evaluate the impact of guided bone regeneration and defect dimension on wound healing at chemically modified titanium implant surfaces (modSLA).
ModSLA implants were placed at chronic-type lateral ridge defects of different heights (H1-H4: 2, 4, 6 and 8 mm) and randomly allocated to either (a) GBR (polyethylene g...
The present study aimed at investigating the impact of defect configuration on the clinical outcome of surgical regenerative therapy of peri-implantitis lesions using a natural bone mineral in combination with a collagen membrane (NBM+CM).
Twenty-seven patients (n=27 defects) exhibited three different types of peri-implantitis lesions including eit...
To evaluate (i) the effects of rhPDGF-BB on localized ridge augmentation using a natural bone mineral (NBM), and (ii) the influence of a collagen membrane (CM) on factor activity.
Chronic-type alveolar ridge defects (n = 4 dogs) were randomly allocated in a split-mouth design as follows: upper jaw: NBM + rhPDGF-BB + CM (test) vs. NBM + rhPDGF-BB (c...
