October 2024
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12 Reads
Cell Host & Microbe
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October 2024
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12 Reads
Cell Host & Microbe
June 2023
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86 Reads
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21 Citations
Techniques by which to genetically manipulate members of the microbiota enable both the evaluation of host-microbe interactions and an avenue by which to monitor and modulate human physiology. Genetic engineering applications have traditionally focused on model gut residents, such as Escherichia coli and lactic acid bacteria. However, emerging efforts by which to develop synthetic biology toolsets for "nonmodel" resident gut microbes could provide an improved foundation for microbiome engineering. As genome engineering tools come online, so too have novel applications for engineered gut microbes. Engineered resident gut bacteria facilitate investigations of the roles of microbes and their metabolites on host health and allow for potential live microbial biotherapeutics. Due to the rapid pace of discovery in this burgeoning field, this minireview highlights advancements in the genetic engineering of all resident gut microbes.
... Multi-strain microbial consortia enable division of labor, which reduces the metabolic load on individual organisms and allows for the entire consortium to behave more efficiently (2)(3)(4). This benefit has led to advances in microbiome engineering (5)(6)(7)(8), bioremediation (9)(10)(11)(12)(13)(14), and bioproduction (2,3,(15)(16)(17)(18), making consortia engineering one of the fastest growing fields in synthetic biology. Most natural microbial communities are made of many species working together. ...
June 2023