Joseph Sawadogo’s scientific contributions

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Publications (8)


Target genes, miRNA regulatory mechanisms and gene therapy ethics.
Gene therapy for Parkinson’s Disease and Ethical Challenges: A Systematic Review
  • Article
  • Full-text available

January 2023

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85 Reads

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1 Citation

Advances in Parkinson's Disease

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Joseph Sawadogo

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Figure 1. Algorithm for the inclusion of samples in the panel according to the results obtained with the DECISCAN HCV Plus.
Figure 2. Receiver Operating Characteristics (ROC) curve comparing the performance of SD BIOLINE HCV and HCV TRI-DOT tests in blood donors.
Figure 3. Proposal for an algorithm for serological screening for HCV including HCV TRI-DOT kit.
Socio-demographic characteristics of blood donors.
Performances of SD BIOLINE HCV and HCV TRI-DOT.
Evaluation of Two Serological Screening Kits for Hepatitis C Virus Infection at the Regional Blood Transfusion Center of Ouagadougou, Burkina Faso

November 2020

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170 Reads

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1 Citation

Advances in Infectious Diseases

Introduction: In Burkina Faso, screening for hepatitis C virus in blood donations is made using sensitive ELISA (Enzyme Linked Immuno Sorbent Assay) type kits. However, no confirmation of the positive results obtained with these kits is made before their notification to the blood donors due to the high costs of the confirmation kits of immunoblots type. Objective: Evaluate two rapid kits against one immunoblot kit in order to determine the most efficiency which will be proposed as an alternative for the confirmation of ELISA tests in the socioeconomic context of Burkina Faso. Material and Methods: The study was carried out using a panel of 72 sera, of which 22 were positive for anti-HCV antibodies and 50 were negative. The sera were tested using the Monolisa® HCV Ag-Ab ULTRA kit and confirmed with the DECISCAN HCV Plus kit. The panel was then tested with the SD BIOLINE HCV kit and the HCV TRI-DOT kit and the results obtained were evaluated against those of the DECISCAN HCV Plus kit used as "gold standard". Results: Compared to the DECISCAN HCV Plus kit, the HCV TRI-DOT kit exhibited a sensitivity and specificity of 100% and the SD BIOLINE HCV kit a sensitivity of 86.36% and a specificity of 100%. Conclusion: Based on the results recorded by the HCV TRI-DOT kit, it would be best suited to the se-How to cite this paper:


Philosophical and ethical issues of sedation in the terminal phase of disease : a return to existential questions

November 2019

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49 Reads

International Journal of Current Research

Sedation in the terminal phase of disease or outside any progressive pathology lea rethink the para "desire to live" and the "un "another" life, or in a superior being who is the master of their life, is it legiti wait for their "death"? Should doctors or their relatives decide on their "life" and "death" them "alive" for the inevitable outcome? terminally ill patients feel gu legalize euthanasia through sedation no less heated and the arguments put forward on both sides rejection of a form of "assisted suicide" we think. Arguments such as "accomplished life" and "life fatigue" are increasingly raised justify the free choice of is threefold management of physical and psychological pain/suffering; 2. help relatives finally, 3. provide practitioners with benchmarks and points of reference, respecting the Hippocratic Oath, and their duties as humanists.


Table 1 . Classification of age groups by gender.
Table 2 . Level of education and knowledge about HIV by gender.
Table 3 . Classification by gender and age at first sexual intercourse.
Table 5 . Knowledge of HIV/AIDS prevention and transmission.
World Journal of AIDS, 2011, 1, **-** Human Immunodeficiency Virus Prevention among HIV-Serodiscordant Couples in Burkina Faso: Biomedical Issues, Bioethical and Cultural Challenges

January 2011

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123 Reads

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4 Citations

World Journal of AIDS

Context: In Burkina Faso, there are young HIV-serodiscordant partners who want to get married and wish to procreate. Objectives: The purpose of this research was: 1) to assess the sexual behaviour of young people in Burkina Faso, 2) to estimate their knowledge about the modes of HIV transmission, 3) to appreciate the cultural reasons of the desire to procreate among HIV serodiscordant couples and 4) to draw some bioethical lessons. Methods: From April to Septem-r 2009, the survey on HIV and reproductive health in Burkina Faso carried out with 815 young people. Among them, 407 were females and 408 males (average age: 23.59 ± 2.99). They have voluntarily agreed to answer a questionnaire which gave the following results. Results: This study shows that young people in Burkina Faso had their first sexual intercourse at 18.99 ± 2.76 years, 23.68% (193/815) were afraid to be tested for HIV, 30.92% (252/815) have not yet been tested for HIV-serostatus and 39.75% (324/815) of them have never heard of HIV vertical transmission. Despite the fact that 36.81% (300/815) are HIV negative, they would be willing to marry the beloved HIV positive person and amongst them, 28.34% (231/815) want a child even with an HIV positive person beloved. Conclusion: So far, there is no effective vaccine against HIV. However, it is clear that Highly Active Anti-Retroviral Therapy (HAART) associated with ethical and cultural good options can contribute to reduce the spread of HIV in Sub-Saharan Africa.

Citations (5)


... It is important to consider the ethical standards of informed consent for adults and minors with cognitive impairment. Prior to PD Gene Therapy, patients must be informed of the risks and benefits of the therapy to be applied, as well as how the results will be used and shared to enable patients to freely give informed consent before gene therapy is initiated [8]. All the more so as genetic information is highly sensitive and must be handled with caution, care and discretion. ...

Reference:

Gene therapy for Parkinson’s Disease and Ethical Challenges: A Systematic Review
Presymptomatic Diagnosis and Gene Therapy for Alzheimer’s Disease: Genomic, Therapeutic, and Ethical Aspects—A Systematic Review

Advances in Alzheimer's Disease

... Access to capital and talent remain significant barriers to the start-up and the established business in adopting emerging technologies. (Sawadogo & Simpore, 2023) (Boguszewicz et al.2021) (Ezdina, 2021) (Bradu et al.2023) ...

Would the Convergence of Nanotechnology, Biotechnology, Information Technology and Cognitive Science Be a Springboard for Transhumanism and Posthumanism?

Open Journal of Philosophy

... In the anthropology of African peoples such as the Bantu, the Mossi, the Fon, the Yoruba, the Nyô-nyôse, etc., helping a sick individual to strengthen their "Vital Force" is an admirable and commendable act that charms people, especially the ancestors who observe and judge the actions of the living in relation to the customs and traditions they left behind before definitively leaving this world (Sawadogo & Simpore, 2022). It is through the imperative recommendation of ancestral observances, and in order to always be faithful to the ancestors, that one can understand the individual and social commitment to the therapeutic care of the sick in Africa. ...

Personalism in African Cultures and Ethics: The Examples of the Bantus in Central, Southern Africa and of the Mossi in West Africa

Advances in Anthropology

... Open Access are also pressing issues, especially in multi-transfused patients such as those undergoing haemodialysis for chronic renal failure (CRF). 4,8,9,10 Anaemia is highly prevalent in end-stage renal disease patients, often non-regenerative normochromic normocytic anaemia caused by inadequate renal erythropoietin production. Erythropoietin infusions or other erythropoietinstimulating agents manage anaemia in end-stage renal disease patients. ...

Evaluation of Two Serological Screening Kits for Hepatitis C Virus Infection at the Regional Blood Transfusion Center of Ouagadougou, Burkina Faso

Advances in Infectious Diseases

... It revealed that HIV positive women who were in the early phase of their marriage (1-5 years duration) were fi ve times more likely to desire more children compared to those who had been married for over 15 years. This is consistent with a study conducted in Ethiopia where it was found that marital length less than 4 years, within 5-9 years and 10-14 years were [29,37]. This was, however, in contrast to the fi ndings in this study as no signifi cant association was found between these variables. ...

World Journal of AIDS, 2011, 1, **-** Human Immunodeficiency Virus Prevention among HIV-Serodiscordant Couples in Burkina Faso: Biomedical Issues, Bioethical and Cultural Challenges

World Journal of AIDS