Joseph S. Redding's research while affiliated with University of South Carolina and other places
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Publications (21)
Electromechanical dissociation (EMD) (organized ECG activity without myocardial contractions) is thought to be rare and associated with poor prognosis. Epinephrine, calcium chloride, and atropine are recommended during attempted resuscitation. Epinephrine's effectiveness in other forms of cardiac arrest is due to its alpha-adrenergic action. Its be...
Two new catecholamines, dopamine and dobutamine, have found widespread use for cardiovascular support. The relative efficacy of these drugs in aiding resuscitation from cardiopulmonary arrest is unknown. Dogs were subjected to either asphyxial or fibrillatory cardiac arrest. Resuscitation was attempted with artificial ventilation, closed chest card...
In central nervous system (CNS) depressed patients, a sequential approach is necessary to prevent airway obstruction and aspiration of vomitus. Endotracheal intubation is indicated if the lash reflex is absent, response to stimulation is not purposeful, or airway obstruction develops when the patient's neck is flexed. Aspiration may result from CNS...
The mean inhaled oxygen concentrations received from five devices commonly used for delivering supplemental oxygen to spontaneously breathing patients were determined. The ideal technic for the determination would require direct measurement of mean alveolar oxygen concentration. Since this is not feasible, we plotted arterial oxygen tensions agains...
Expense, noise, and bright lighting have been acknowledged disadvantages of ICU's since their establishment. Data are available regarding the first, but not the latter two disadvantages. Background sound levels were measured in four units and found to be comparable to the hospital cafeteria at noon, and only somewhat less noisy than the boiler room...
Following the adoption of exhaled air ventilation and external cardiac compression, it was shown that the combination restored normal arterial oxygenation within 1 minute in dogs asphyxiated to circulatory arrest. Disappointingly, spontaneous cardiac activity was restored in only two of ten dogs (1). This was due to the limited tissue perfusion res...
Several thousand people die each year in this country as the result of drowning. Most of them are young and in good health. No single disease accounts for as many deaths in people under age 24, yet relatively little is known about this costly killer. For centuries the search for a solution to this problem was frustrated by lack of understanding of...
To the Editor.—
In reference to the letters submitted by Tacker et al (235:144, 1976) and Crampton et al (235:2284, 1976), resolution of the apparent conflict may lie in consideration of variables other than body weight that influence ventricular defibrillation. References can be found in the literature to such factors as frequency of countershock...
A forceful blow to the precordium has been recommended as the first resuscitative measure following diagnosis of cardiac arrest. This is the result of sporadic reports that precordial thumping was followed by recovery of patients thought to have cardiac arrest. In 1920, Schott first reported that a blow to the chest restored a palpable pulse in a p...
Citations
... 6 Midwives, FN3;10 in their isolation from the medical profession, were meantime likely to be applying mouth-to-mouth expired air ventilation (EAV), 11 practised from before 1472 and the time of Paoli Bagellardi 11 when required for neonatal resuscitation, as was also outlined in Part 1. 9 But as Joseph Redding has explained: "... the technique was considered inelegant and undignified by physicians, who felt it was beneath their notice and of little concern to them". 12 Thus, in 1776, "William Hunter spoke of mouthto-mouth inflation as the method practised by the vulgar to restore stillborn children". 13 ...
... The cause for these sleep disturbances in the ICU are thought to be multifactorial, with environmental factors probably being the most important. The environmental factor most often cited in the literature as a sleep disturbing factor is noise [2,[6][7][8]. Other contributing factors include but are not limited to: the administration of sleep altering medications, how the intensive care unit (ICU) environment is structured and the effects of acute illness [9]. ...
Reference: Noise Levels and Sleep in a Surgical ICU
... Moreover, PaO 2 /FiO 2 was initially proposed in mechanically ventilated patients, where FiO 2 is carefully measured. In non-mechanically ventilated patients, as patients in conventional O 2 mask or high-flow nasal cannula (HFNC), the assessment of the true FiO 2 in the inspired mixture may be problematic, specifically in dyspneic/ tachypneic patients with high inspiratory peak flow or with the mouth breathing during HFNC [3,4]. Therefore, PaO 2 /FiO 2 values during the transition through the different methods of O 2 delivery could lead to misinterpretation of the degree of respiratory dysfunction. ...
... 6 Methoxyflurane produced postoperative pain relief equivalent to 10 mg of intramuscular morphine without respiratory depression. 7 Unlike the analgesia produced by nitrous oxide, which is late in onset and disappears rapidly upon recovery, methoxyflurane analgesia appeared early and persisted well into the recovery period because of its high blood gas partition coefficient and resultant slow elimination during emergence. 8 Methoxyflurane was also reported to have an anxiolytic effect. ...
Reference: The Reincarnation of Methoxyflurane
... It has also been shown that passive chest compressions, applied for cardiopulmonary resuscitation, can lead to ventricular excitation, resulting in active cardiac contractions (451,452). However, since its inception, interest in percussion pacing has always been contrasted by questions about its utility (675,702), fueled by a lack of prospective clinical studies (469) and mechanistic explanations. ...
... In one canine study (LOE 3, fair/opposing), dogs were asphyxiated until asystole occurred, then were randomized to be revived with saline, calcium, atropine, or methoxamine. 53 No dogs randomized to receive atropine (0.5 mg/animal; body weight 11-25 kg) were successfully resuscitated. In a third canine study (LOE 3, fair/supporting), dogs with PEA were randomized to be resuscitated with epinephrine and either atropine (0.5 mg/animal; mean bodyweight 20 kg) or 5% dextrose in water. ...
... A number of animal models have been used to which study the effect of sympathetic activity during CPR. Otto and Yakaitis studied the use of drugs during cardiac arrest in dogs and observed that the drugs used to achieve sympathetic activation of heart during CPR have no value in the therapy of cardiac arrest [3]. Redding and Pearson studied CPR in dogs and observed that while drugs inducing sympathetic activation of heart are not useful for resuscitation, the drugs inducing sympathetic activation of peripheral arteries are useful [4]. ...
