Joseph R. Starrett's research while affiliated with University of Massachusetts Amherst and other places

Publications (3)

Article
Estrogens affect cerebellar activity and cerebellar-based behaviors. Within the adult rodent cerebellum, the best-characterized action of estradiol is to enhance glutamatergic signaling. However, the mechanism(s) by which estradiol promotes glutamatergic neurotransmission remain unknown. Within the mouse cerebellum, we find that estrogen receptor a...
Article
The potent estrogen 17β-Estradiol (E2) plays a critical role in mediating hippocampal function, yet the precise mechanisms through which E2 enhances hippocampal memory remain unclear. In young adult female rodents, the beneficial effects of E2 on memory are generally attributed to ovarian-synthesized E2. However, E2 is also synthesized in the adult...

Citations

... L'activation de ces récepteurs mène à l'activation de mGluR1a et promeut la neurotransmission au niveau de la synapse entre les FP et les PC. En conséquence, cela potentialise l'activité glutamatergique dans le cervelet (Hedges et al. 2018 ...
... This reduction in neuroestrogens has been linked to a decreased expression of hippocampal aromatase following OVX Ma et al. 2020). In OVX mice, aromatase inhibition also reduces neuroestrogen synthesis over the long term, which impairs memory consolidation (Baumgartner et al. 2019;Tuscher et al. 2016). However, E2 treatment following OVX seems to maintain neuroestrogen levels, thus enhancing memory Ma et al. 2020). ...