Jose L Cantero's research while affiliated with Instituto de Salud Carlos III and other places

Publications (183)

Article
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Background Non-modifiable risk factors of Alzheimer’s disease (AD) have lifelong effects on cortical integrity that could be mitigated if identified at early stages. However, it remains unknown whether cortical microstructure is affected in older individuals with non-modifiable AD risk factors and whether altered cortical tissue integrity produces...
Article
Cholesterol and the immune system are involved in Alzheimer's Disease (AD). To investigate the relations among them, we compared the cholesterol content in peripheral blood mononuclear cells (PBMC) of cognitively healthy controls and patients with mild cognitive impairment (MCI) and AD in two independent samples. Free cholesterol content of PBMC wa...
Article
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Background and aim The appearance of alterations in normal metabolic activity has been increasingly considered a risk factor for the development of sporadic and late-onset neurodegenerative diseases. In this report, we induced chronic metabolic stress by feeding of a high-fat diet (HFD) in order to study its consequences in cognition. We also studi...
Article
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Insulin resistance and glucose dysregulation are associated with patterns of regional brain hypometabolism characteristic of Alzheimer’s disease (AD). As predicted by evidence linking brain glucose metabolism to brain functional connectivity, type 2 diabetes is accompanied by altered functional connectivity density (FCD) in regions highly vulnerabl...
Article
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This research presents an analysis of real production data of an automatic drilling industrial system and emphasizes its ability as a process control indicator in terms of tool wear. In particular, the study is framed in Carbon-fiber-reinforced polymer composites (CFRPs) drilling operations carried out at Airbus facilities. The industrial process d...
Article
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Evidence suggests that lightly myelinated cortical regions are vulnerable to aging and Alzheimer’s disease (AD). However, it remains unknown whether plasma markers of amyloid and neurodegeneration are related to deficits in intracortical myelin content, and whether this relationship, in turn, is associated with altered patterns of resting-state fun...
Article
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Ongoing challenges in advanced manufacturing highlight the need of improved control of the production system, higher production speed, lower tool wear, top quality standards together with reduced material waste to minimize associated costs, time and environmental footprint. The organization of production resources through the integration of data al...
Article
This work focuses on the analysis of the influence of different machining factors on the fretting fatigue behaviour of Inconel 718. Fretting fatigue tests using a flat-to-flat with rounded edges contact were carried out using specimens with different manufacturing process parameters. The results pointed out the high impact that machining parameters...
Article
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Coronavirus 2 (SARS-CoV2) (COVID-19) causes severe acute respiratory syndrome. Severe illness of COVID-19 largely occurs in older people and recent evidence indicates that demented patients have higher risk for COVID-19. Additionally, COVID-19 further enhances the vulnerability of older adults with cognitive damage. A balance between the immune and...
Article
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Despite the interest of industry in nickel-based superalloys and its main features (high temperatures resistance, hardness, low thermal conductivity, among others), even today they are still materials that are difficult to cut. Cutting tools withstand both high pressures and temperatures highly localized at the cutting area because of the elevated...
Article
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Evidence suggests that aging-related dysfunctions of adipose tissue and metabolic disturbances increase the risk of diabetes and metabolic syndrome (MtbS), eventually leading to cognitive impairment and dementia. However, the neuroprotective role of adipocytokines in this process has not been specifically investigated. The present study aims to ide...
Article
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New dietary approaches for the prevention of cognitive impairment are being investigated. However, evidence from dietary interventions is mainly from food and nutrient supplement interventions, with inconsistent results and high heterogeneity between trials. We conducted a comprehensive systematic search of randomized controlled trials (RCTs) publi...
Article
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Background Aging is associated with declining protective immunity and persistent low-grade inflammatory responses, which significantly contribute to Alzheimer’s disease (AD) pathogenesis. Detecting aging-related cerebral vulnerability associated with deterioration of the immune system requires from non-invasive biomarkers able to detect failures in...
Article
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There is evidence suggesting that online consolidation during retrieval-mediated learning interacts with offline consolidation during subsequent sleep to transform memory. Here we investigate whether this interaction persists when retrieval-mediated learning follows post-training sleep and whether the direction of this interaction is conditioned by...
Article
Background Recognizing vulnerability to Alzheimer's disease (AD) requires from non-invasive, simple, and inexpensive markers that can be easily obtained in primary care settings. While saliva meets all these requirements, there is lack of evidence linking salivary constituents to in vivo AD pathology in aging. Methods We examined the potential of...
Article
Efforts focused on developing new less invasive biomarkers for early Alzheimer’s disease (AD) diagnosis are substantial. Evidences of infectious pathogens in AD brains may suggest a deteriorated defensive system in AD pathology. Lactoferrin (Lf), one of the major antimicrobial peptides in saliva, is an important oral defensive system that may contr...
Article
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Identifying cerebral vulnerability in late life may help prevent or slow the progression of aging-related chronic diseases. However, non-invasive biomarkers aimed at detecting subclinical cerebral changes in the elderly are lacking. Here, we have examined the potential of plasma total tau (t-tau) for identifying cerebral and cognitive deficits in n...
Article
Carbon-fiber-reinforced polymer composites (CFRPs) are widely used in industry due to their outstanding mechanical properties combined with reduced density and good corrosion and fatigue resistance. Although composite components are manufactured near net shape, further machining operations are required. Drilling is the most common operation, involv...
Article
Full-text available
Alzheimer’s disease (AD) manifests with progressive memory loss and spatial disorientation. Neuropathological studies suggest early AD pathology in the entorhinal cortex (EC) of young adults at genetic risk for AD ( APOE ε4-carriers). Because the EC harbors grid cells, a likely neural substrate of path integration (PI), we examined PI performance i...
Article
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Background Evidences of infectious pathogens in Alzheimer's disease (AD) brains may suggest a deteriorated innate immune system in AD pathophysiology. We previously demonstrated reduced salivary lactoferrin (Lf) levels, one of the major antimicrobial proteins, in AD patients. Methods To assess the clinical utility of salivary Lf for AD diagnosis,...
Preprint
Full-text available
Background Efforts focused on developing new less invasive biomarkers for early Alzheimer’s disease (AD) diagnosis are substantial. Evidences of infectious pathogens in AD brains may suggest a deteriorated innate immune system in AD pathophysiology. We previously demonstrated reduced salivary levels of Lf in AD patients, one of the major antimicrob...
Article
Full-text available
Identifying cerebral vulnerability in late life is of paramount importance to prevent pathological trajectories of aging before the onset of symptoms. Considerable evidence suggests that impaired antioxidant mechanisms are a fingerprint of aging-related conditions, but there is a lack of human research linking total antioxidant capacity (TAC) measu...
Article
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Sleep is thought to play a complementary role in human memory processing: sleep loss impairs the formation of new memories during the following awake period and, conversely, normal sleep promotes the strengthening of the already encoded memories. However, whether sleep can strengthen deteriorated memories caused by insufficient sleep remains unknow...
Article
Evidence suggests that the basal forebrain (BF) cholinergic system degenerates early in the course of Alzheimer's disease (AD), likely due to the vulnerability of BF cholinergic neurons to tau pathology. However, it remains unclear whether the presence of tauopathy is the only requirement for initiating the BF degeneration in asymptomatic subjects...
Article
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Background: Previous studies have shown that expression levels of miR-181c are downregulated by amyloid-β (Aβ) deposition and chronic cerebral hypoperfusion, both factors largely associated with the development of AD. Moreover, reduced 2-[18F]fluoro-2-deoxy-D-glucose (FDG)-PET brain metabolism and volume loss of regions of the medial temporal lobe...
Article
The use of 100% biodegradable composites in the industry is increasing significantly over the years, mainly due to their excellent properties as well as to the growing ecologic concern. However, after their manufacture, the composite pieces do not always have the final shape, requiring subsequent processing operations, usually drilling and trimming...
Preprint
Full-text available
Alzheimer's disease (AD) manifests with progressive memory loss and spatial disorientation. Neuropathological studies suggest early AD pathology in the entorhinal cortex (EC) of young adults at genetic risk for AD (APOE ϵ4-carriers). Because the EC harbors grid cells, a likely neural substrate of path integration (PI), we examined PI performance in...
Poster
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Previous studies have shown that total sleep deprivation and suppression of slow-wave activity the night before memory acquisition can be so disrupting to encoding processes that subsequent sleep is unable to restore the deteriorated memories1,2. While these experimental manipulations are not commonly encountered in the daily life, insufficient sle...
Article
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Nickel-based superalloys exhibit an exceptional combination of corrosion resistance, enhanced mechanical properties at high temperatures, and thermal stability. The mechanical behavior of nickel-based superalloys depends on the grain size and the precipitation state after aging. Haynes 282 was developed in order to improve the creep behavior, forma...
Article
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Hybrid stack drilling is a very common operation used in the assembly of high-added-value components, which combines the use of composite materials and metallic alloys. This process entails the complexity of machining very dissimilar materials, simultaneously, on account of the interactions that are produced between them, during machining. This stu...
Article
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Drilling operations on Carbon Fiber Reinforced Plastics (CFRP) have become crucial for the manufacturing process of multiple components on the aerospace industry. The main objective of this research is to develop a comparative analysis between a step geometry drill bit, currently used in the aerospace industry for drilling processes in CFRP with a...
Article
Evidence has shown that microRNAs (miRNAs) are involved in molecular pathways responsible for aging and prevalent aging-related chronic diseases. However, the lack of research linking circulating levels of miRNAs to changes in the aging brain hampers clinical translation. Here, we have investigated if serum expression of brain-enriched miRNAs that...
Article
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Nickel-based superalloys are widely used in the aeronautical industry, especially in components requiring excellent corrosion resistance, enhanced thermal fatigue properties, and thermal stability. Haynes 282 is a nickel-based superalloy that was developed to improve the low weldability, formability, and creep strength of other γ’-strengthened Ni s...
Article
Aging is characterized by a progressive increase in proinflammatory status. This state, known as inflammaging, has been associated with cognitive decline in normal and pathological aging. However, this relationship has been inconsistently reported, likely because it is conditioned by other factors also affected by the aging process. Sleep and adipo...
Article
Full-text available
Inconel 718 is a Ni superalloy widely used in high responsibility components requiring excellent mechanical properties at high temperature and elevated corrosion resistance. Inconel 718 is a difficult to cut material due to the elevated temperature generated during cutting, its low thermal conductivity, and the strong abrasive tool wear during cutt...
Poster
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Estudios previos han revelado que la restricción aguda de sueño (RAS) en la noche previa a la adquisición de nueva información en una tarea de memoria asociativa supone cambios en el recuerdo de dicha información medido dos días más tarde (Alberca-Reina et al. 2014).
Conference Paper
Inconel 718 is one of the most relevant nickel-based superalloys because of its unique properties at high temperatures, such as a high tensile and fatigue strength and elevated resistance to corrosion. On the other hand, Inconel 718 is a difficult material to cut because of its chemical affinity to cutting tool materials and poor thermal conductivi...
Article
Full-text available
Inconel 718 is a superalloy, considered one of the least machinable materials. Tools must withstand a high level of temperatures and pressures in a very localized area, the abrasiveness of the hard carbides contained in the Inconel 718 microstructure and the adhesion tendency during its machining. Mechanical properties along with the low thermal co...
Article
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Considerable evidence suggests that circadian rhythmicity is progressively disrupted in senescence. Among clock genes, Period3 (PER3) has been associated with circadian phenotypes, homeostatic regulation of sleep, and cognitive performance in young adults. However, the effects of PER3 genotype on aging-related changes in both cognitive function and...
Article
In mild cognitive impairment (MCI), the APOE4 genotype is associated with accelerated memory decline, likely due to the impact of neuropathology on main cerebral networks required for successful memory retrieval and/or to decreased capacity for recruiting secondary networks that might compensate for that brain damage. Here, we tested this hypothesi...
Article
Full-text available
Inconel 718 is a nickel-based superalloy widely used in the aerospace industry, nuclear plants and gas turbines due to the exceptional mechanical properties and resistance to corrosion at elevated temperature. For these reasons Inconel 718 have a low machinability due to the high temperatures that appear in the cutting area in addition to the wear...
Article
Full-text available
This work focuses on the analysis of Composite Fiber Reinforced Plastics (CFRP) drilling performed during the assembly of aeronautical components. One-shoot operations are desired to minimize positional errors, enhance tight tolerances and reduce process time. Also, it is usually included the countersinking cycle to maintain the aerodynamic shape o...
Article
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Ni-based superalloys are extensively used in high-responsibility applications in components of aerospace engines and gas turbines with high temperature service lives. The wrought, γ′-strengthened superalloy Haynes 282 has been recently developed for applications similar to other common superalloys, such as Waspaloy or Inconel 718, with improved cre...
Article
Full-text available
Tremendous progress has been made over the last few years in understanding how sleep and amyloid-β (Aβ) cooperate to speed up the progression of Alzheimer’s disease (AD). However, it remains unknown whether sleep deficits also interact with other risk factors that exacerbate the pathological cascade of AD. Based on evidence showing that higher leve...
Article
The diagnostic value of cerebrospinal fluid (CSF) biomarkers is well established in Alzheimer's disease, but our current knowledge about how abnormal CSF levels affect cerebral integrity, at local and network levels, is incomplete in asymptomatic older adults. Here, we have collected CSF samples and performed structural magnetic resonance imaging s...
Poster
Full-text available
Estudios previos han revelado que una restricción aguda de sueño aplicada en la noche previa a la adquisición de la memoria modifica la estrategia utilizada posteriormente para acceder a esa información (Alberca-Reina et al., 2015), lo cual podría deberse en parte a los cambios funcionales que se producen en la noche de consolidación. La concentrac...
Article
Composite Fiber Reinforced Plastics (CFRP) are characterized by their outstanding mechanical properties combined with reduced density and good resistance to corrosion and fatigue which make them suitable for aerospace components. During assembly procedures, one shoot drilling operations, usually including countersinking cycle, are required to minim...
Poster
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Los procesos cognitivos a lo largo de la vida se ven influenciados en gran medida por el estilo de vida, destacando aspectos como la dieta, la actividad física o el sueño. Una de las capacidades cognitivas que sufre un mayor declive con el envejecimiento es la memoria episódica. El principal objetivo del presente trabajo fue evaluar el efecto del e...
Article
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Introduction The Alzheimer's disease (AD) process is likely initiated many years before clinical onset. Biomarkers of preclinical disease are critical for the development of disease-modifying or even preventative therapies. Current biomarkers for early disease, including cerebrospinal fluid tau and amyloid β (Aβ) levels, structural and functional m...
Article
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Synaptic dysfunction, a key pathophysiological hallmark of Alzheimer’s disease (AD), may account for abnormal memory-related EEG patterns in prodromal AD. Here, we investigate to what extent oscillatory EEG changes during memory encoding and/or retrieval enhance the accuracy of medial temporal lobe (MTL) atrophy in predicting conversion from amnest...
Article
Extensive research suggests that basal forebrain (BF) cholinergic neurons are selectively vulnerable to Alzheimer's disease (AD). However, it remains unknown whether volume loss of BF cholinergic compartments parallels structural changes of their innervated regions in prodromal AD. To this aim, we have correlated volume of each BF compartment with...
Article
The main goal of this paper is to show the new learning methodologies in techniques of forming process modelling in the context of Master in Industrial Engineering. In this context, Computer integrated manufacturing (CIM) has been established as a valuable tool for manufacturing process. The methodology developed in this work combines the process d...
Article
Background: Evidence suggests a link between the presence of subjective memory complaints (SMC) and lower volume of the hippocampus, one of the first regions to show neuropathological lesions in Alzheimer's disease. However, it remains unknown whether this pattern of hippocampal atrophy is regionally specific and whether SMC are also paralleled by...
Article
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Previous studies have shown that the topological organization of the cerebral cortex is altered in Alzheimer’s disease (AD). However, it remains unknown whether different levels of the cortical hierarchy are homogeneously affected during disease progression, and which of these levels are mostly involved in the breakdown of metabolic (functional) conn...
Article
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Machining processes of Carbon Fiber Reinforced Polymer (CFRP) are commonly required in order to achieve final assembly specifications. Despite the good mechanical properties of this kind of materials, they are hard to be machined due to the presence of hard particles; delamination, fiber pull-out and matrix thermal degradation are usually observed...
Article
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Drilling is one of the most frequent machining operations for carbon fiber-reinforced polymer composites, carried out prior to assembly between structural components using mechanical joining. Delamination is the main damage mechanism involved during carbon fiber-reinforced polymer composite drilling causing an elevated percentage of workpiece rejec...
Article
Evidence shows that sleep loss before learning decreases activation of the hippocampus during encoding and promotes forgetting. But it remains to be determined which neural systems are functionally affected during memory retrieval after one night of recovery sleep. To investigate this issue, we evaluated memory for pairs of famous people's faces wi...
Article
Plasma levels of circulating amyloid-beta (Aβ) peptides are of particular interest in Alzheimer' disease, but little is known about cognitive and cortical correlates of peripheral Aβ levels in normal aging. Here, we compared cognitive functioning, vascular risk factors, and patterns of cortical thickness between cognitively intact elderly subjects...
Article
People with amnestic mild cognitive impairment (aMCI), compared to healthy older adults (HO), benefit less from semantic congruent cues during episodic encoding. The presence of the apolipoprotein E (APOE) ε4 makes this congruency benefit smaller, but the neural correlates of this deficit are unknown. Here, we estimated the source generators of EEG...
Article
Full-text available
Growing evidence suggests that decreased functional connectivity in cortical networks precedes clinical stages of Alzheimer's disease (AD), although our knowledge about cerebral and biological correlates of this phenomenon is limited. To shed light on this issue, we have investigated whether resting-state oscillatory connectivity patterns in health...
Conference Paper
Evidence suggests that amyloid-beta (Aβ) deposition parallels sleep deficits in Alzheimer’s disease (AD). However, it remains unknown whether impaired sleep and changes in plasma Aβ levels are related in amnestic mild cognitive impairment (aMCI) subjects, and whether both markers are further associated with cortical thinning in canonical AD reg...
Conference Paper
Full-text available
Accumulated evidence has shown that functional cortical circuits are affected in MCI subjects (Cantero et al. 2009, Babiloni et al. 2006; Koenig et al. 2005; Pijnenburg et al. 2004). However, it remains unknown whether abnormal patterns of cortical oscillatory coupling are associated with changes of cortical gray matter (GM) and cerebral white matt...
Conference Paper
People with amnestic mild cognitive impairment (aMCI), like healthy older adults (HO), present a disproportionate deficit in associative memory; but unlike HO, they do not benefit from semantic congruence. The presence of the 4 allele of the apolipoprotein E gene (APOE) makes this memory loss worse. Here, we show that encoding of face-location ass...
Chapter
Neuroscientists have provided strong evidence in the last two decades that sleep contributes to building new memories. However, we are a long way from understanding the specific mechanisms responsible for this achievement. One general belief held by sleep researchers is that offline reactivation of experience-specific activity patterns during sleep...
Conference Paper
The influence of tool geometry in drilling woven CFRPs materials is analyzed in this paper. Three different point angles were tested with fresh tool and worn tool (honed edge). The results showed increasing feed forces when drilling with high point angles using worn tool. Delamination showed opposite trends with the variation of geometry at hole en...