July 2013
·
4 Reads
·
1 Citation
This page lists works of an author who doesn't have a ResearchGate profile or hasn't added the works to their profile yet. It is automatically generated from public (personal) data to further our legitimate goal of comprehensive and accurate scientific recordkeeping. If you are this author and want this page removed, please let us know.
July 2013
·
4 Reads
·
1 Citation
July 2013
·
31 Reads
May 2013
·
109 Reads
·
109 Citations
The Journal of Neuroscience : The Official Journal of the Society for Neuroscience
Ligands of the translocator protein (TSPO) elicit pleiotropic neuroprotective effects that represent emerging treatment strategies for several neurodegenerative conditions. To investigate the potential of TSPO as a therapeutic target for Alzheimer's disease (AD), the current study assessed the effects of the TSPO ligand Ro5-4864 on the development of neuropathology in 3xTgAD mice. The effects of the TSPO ligand on neurosteroidogenesis and AD-related neuropathology, including β-amyloid accumulation, gliosis, and behavioral impairment, were examined under both early intervention (7-month-old young-adult male mice with low pathology) and treatment (24-month-old, aged male mice with advanced neuropathology) conditions. Ro5-4864 treatment not only effectively attenuated development of neuropathology and behavioral impairment in young-adult mice but also reversed these indices in aged 3xTgAD mice. Reduced levels of soluble β-amyloid were also observed by the combination of TSPO ligands Ro5-4864 and PK11195 in nontransgenic mice. These findings suggest that TSPO is a promising target for the development of pleiotropic treatment strategies for the management of AD.
... Translocator protein (TSPO) is a protein of the outer mitochondrial membrane, which has been implicated in numerous central nervous system pathologies [30][31][32][33]. It was initially named the peripheral benzodiazepine receptor (PBR) with the updated nomenclature being adopted to reflect the evolving view that this protein translocates substrates across the outer mitochondrial, a view that nonetheless remains controversial [34]. ...
May 2013
The Journal of Neuroscience : The Official Journal of the Society for Neuroscience