Jonathan Wisler's research while affiliated with The Ohio State University and other places

Publications (8)

Article
Background: The impact of obesity on the pathogenesis and prognosis of necrotizing soft tissue infections (NSTIs) is unclear. The goal of this study was to characterize differences in NSTI presentation and outcomes by obesity status. Patients and Methods: A retrospective analysis of institutional data for patients diagnosed with NSTIs were identifi...
Article
Background: Necrotizing soft tissue infections (NSTIs) are severe, rapidly spreading infections with high morbidity and mortality. Attempts to identify risk factors for mortality and morbidity have produced variable results. We hope to determine which factors across the NSTI population impact mortality, morbidities, and discharge disposition. Patie...
Article
Background Emergency general surgery has higher adverse outcomes than elective surgery. Patients leaving the hospital against medical advice (AMA) have a greater risk for readmission and complications. We sought to identify clinical and demographic characteristics along with hospital factors associated with leaving AMA after EGS operations. Method...
Article
Background: Cholecystectomy is considered a low-risk procedure with proven safety in many high-risk patient populations. However, the risk of cholecystectomy in patients with active cancer has not been established. Methods: The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database was queried to identify...
Article
Background The role of changes in gut microflora on upper gastrointestinal (UGI) perforations is not known. We conducted a retrospective case-control study to examine the relationship between antibiotic exposure—a proxy for microbiome modulation—and UGI perforations in a national sample. Methods We queried a 5% random sample of Medicare (2009–2013...
Article
Full-text available
Aim Genetic and epigenetic mechanisms have been implicated in the pathogenesis of type 1 diabetes (T1D), and histone acetylation is an epigenetic modification pattern that activates gene transcription. However, the genome‐wide histone H3 acetylation in newly onset T1D patients has been less described. Accordingly, we aimed to unveil the genome‐wide...
Article
Background: Little is reported in the literature on management strategies and outcomes in patients with an active cancer diagnosis who undergo emergent general surgery. The purpose of this study is to evaluate preoperative risk factors in both operative and non-operative management, as well as to describe the outcomes of colonic emergencies within...

Citations

... Skin and soft tissue infections are among the most common bacterial infections, accounting for approximately 10% of hospital admissions due to infections in the USA [1,2]. Skin and soft tissue infections represent clinical entities of variable presentations, etiology and severity that involve microbial invasion of the layers of the skin and underlying soft tissues, ranging from mild to serious life-threatening infections. ...
... In the present study, younger age, female sex, prior episode of leaving AMA, prior substance abuse, and prior psychiatric comorbidities were noted to be associated with leaving AMA alike the prior studies. [4][5][6] In our study, we noted that the presence of comorbidities, including prior IE, HCV, substance abuse, polysubstance abuse, history of leaving AMA, multiple prior histories of leaving AMA, presence of psychiatric comorbidities, and socioeconomic factors such as homelessness and social isolation, was associated with statistically significant, higher odds of leaving AMA in IE patients. Medical comorbidities were higher in the IE patients who had completed therapy probably secondary to the older age group of these patients. ...
... Due to their conserved catalytic domains, HDACs have been actively used as therapeutic targets. HDAC-mediated increase in histone affinity for DNA leads to arrest of transcription, whereas HAT-acetylated chromatin is transcriptionally active (Wang et al. 2019b). In recent years, the role of histone methylation/demethylation, acetylation, and deacetylation in diabetes has received increasing attention, becoming promising new targets for the development of novel anti-diabetic drugs. ...