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January 2016
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77 Reads
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6 Citations
This chapter describes various enzyme-catalyzed reactions for production of amino acids and chiral amines. Enantiomerically pure amino acids can be produced from keto acids via amino acid dehydrogenase (AADH) and transaminase (TA). Enantiomerically pure amines are available from prochiral ketones via catalysis with TA, amine oxidase (AO), and amine dehydrogenase (AmDH) enzymes.
... From the operational point of view, high concentrations of ammonia are needed when using the reductive amination reaction, whereas the oxidative reaction yields α-keto acids when starting from amino acid substrates. Whereas most AADHs are L-enantioselective, D-AADHs (EC 1.4.99.1) have also been described (Vedha- Peters et al., 2006;De Wildeman et al., 2007;Hall and Bommarius, 2011;Li et al., 2012;Au et al., 2016;Akita et al., 2018;Zhang et al., 2019). This family of enzymes is greatly diverse, although in general, AADHs are promiscuous enzymes showing a high enantioselectivity (Xue et al., 2018). ...
January 2016
