John Mukhopadhaya’s research while affiliated with Huntington Medical Research Institutes and other places

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Publications (21)


Neglected Pilon Fracture: Techniques of Management
  • Article
  • Full-text available

April 2024

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80 Reads

Journal of Foot and Ankle Surgery (Asia Pacific)

John Mukhopadhaya

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Pilon fractures of the distal tibia are associated with several complications. Late presentations are also not uncommon and together they present many challenges in the management. This review article looks at many of the problems they may present with, and the options available in their treatment with illustrative cases that we have treated over a number of years.

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Outcome of Osteosynthesis of Late Presenting Proximal Humerus Nonunion A Case Series Janki Sharan Bhadani

February 2024

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85 Reads

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2 Citations

Journal of Orthopaedic Case Reports

The study focuses on the successful management of late-presenting proximal humerus non-union (PHN) through osteosynthesis using an intra-medullary strut fibular autograft with a proximal humerus internal locking system (PHILOS) and cancellous bone grafting. The study included six cases of PHN that were presented more than 5 years after the original injury, and achieved satisfactory outcomes with improved shoulder function based on the constant score and disabilities of the arm, shoulder, and hand (DASH) score during the final follow-up. The study utilized a paired sample t-test to compare the difference in mean of the pre-operative and post-operative scores for each patient, and found a significant improvement in shoulder function postoperatively. The demographic data of the patients in the study showed a mean age of 54.3 years, with a female-predominant population, and the mean constant score improved from 26.33 to 71.83 postoperatively. The study concluded that symptomatic PHN can be effectively managed operatively, even in cases where it presents very late, and recommended further research through a prospective, multicentric study to enhance the reliability and efficacy of the findings.




Fig. 1. Radiograph showing ankle fracture dislocation with Pronation-External rotation as a possible mechanism of injury.
Fig. 2. CT Scan showing tibiofibular joint diastasis.
Fig. 3. Radiograph showing Fracture & Syndesmosis fixation with ankle external fixator in situ.
Fig. 4. Radiograph after removal of external fixator.
Fig. 5. Radiograph showing disruption of the tibiofibular syndesmosis with broken screw in situ.

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Arthrodesis of syndesmotic joint for failed fixation of syndesmosis: A case report

April 2023

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537 Reads

Journal of Orthopaedic Reports


Evaluation of Anthropometric Measurements of the Aspect Ratio of Knee in Indian Population and its Correlation with the Sizing of Current Knee Arthroplasty System

December 2022

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78 Reads

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5 Citations

Indian Journal of Orthopaedics

Background Most of the commercially available TKR implants are designed for western populations, which are known to have larger build and stature compared to Asian counterparts often leading to mismatch between resected bony surfaces and implant components. There is paucity of morphometric data of distal femur and proximal tibia in the Indian population. Thus, it becomes important to obtain anthropometric data to achieve the best stability and long-term success of implant.Materials and Methods Intraoperative morphological measurements of 100 knees (59 female and 41 males) were done using vernier calliper during TKR. The anteroposterior (AP) and mediolateral (ML) dimensions of cross-section of the femur and tibia were noted before bony resection. The aspect ratios were calculated and compared with that of implant used (DePuy, Stryker, Maxx).ResultsWe have found that Indian males have larger dimensions of distal femur as well as proximal tibia than females. There exists some degree of mismatch in patients’ dimensions and the sizes of all the three commercially available implant system as well their aspect ratios.Conclusion Specific designing of implants with dimensions in accordance with the morphometric measurements of Indian population should be done. Also gender specific implant designing should be done.


Need to address discrepancies governing the education system in orthopedics: Diplomate of National Board (DNB) doctors dilemma Editorial Journal of Orthopaedic Case Reports 2022 April:12(4):Page 104-106

July 2022

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102 Reads

Journal of Orthopaedic Case Reports

Providing higher education is a dream of every Indian parent. Every Indian student goes through many hurdles while pursuing their career. During the 80s and 90s, a career in medicine was very rewarding for students and parents. The interest in pursuing medical education has slowly declined due to the many problems faced by the parents and their kin. Reasons might be many but initial hiccoughs are difficulty in getting admission into medical college. The second hurdle is securing a postgraduate seat. The current scenario of medical practice is entirely different than it was in the 60s and 70s when an MBBS medical graduation was enough to practice. Globalization has changed the current scenario and expectations of patient-doctor relations where a patient is looking for a specialist with in-depth knowledge about the problem and advanced care and treatment methods. Postgraduate education in orthopedics is divided into two main streams after MBBS. M.S. Orthopaedics where training is done at teaching hospitals and Diplomate of National Board (DNB) orthopedics where training is undergone at corporate hospitals usually, where the surgeons may be interested in teaching but not necessarily in a teaching faculty post. This has led to a debate about the equivalence of DNB and MS degrees, whether acquired from the government or private medical colleges or institutions. We know that DNB is a "centralized postgraduate degree" awarded directly by National Board of Examination (NBE), an autonomous body under the Union Ministry of Health and Family Welfare. It is believed that DNB is equivalent degree to MD/MS and is more recognized abroad as there is no room for manipulation of admission through centralized examination nor during exit examination as the examination center is usually away from the institution. Hence, many postgraduates appear for DNB examinations after passing MS/MD. Quality of DNB trainee depends mainly on the following factors: The number of beds in a hospital, existing infrastructure, and the presence of the experienced faculty-all these matters when a student chooses the institute to pursue the postgraduate course. After all the hurdles, the pass percentage of the DNB candidates is very low, and in spite of this, the number of eligible candidates wanting to pursue DNB courses of their choice is increasing every year but the number of seats, however, is not increasing. Recently, all postgraduate courses be it M.S. (Master of Surgery), DNB, or diploma have been clubbed together through National Eligibility and Entrance Test, which gives a higher chance to a candidate to get the specialty of his/her choice, but DNB Ortho won't be the first choice as the pass percentage is very low compared to the M.S Ortho candidate. We wish to summarize the problems faced by a DNB trainee and the reasons for the low pass percentage and how to improve the pass percentage of the DNB trainee. b. Change in the pattern of question paper a. Candidature capacity versus responsibility of the course provider c. Inequalities in the evaluation of answers d. What are the reasons behind these and how to solve these issues?


Implantology of Fractures of the Neck of Femur

May 2022

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24 Reads

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1 Citation

Femoral head fractures, also known as Pipkins fractures, are more common in young and are usually caused by high-energy trauma. Controversies in the management of Pipkins fracture still exist between excision, osteosynthesis, and arthroplasty. For internal fixation, multiple implants have been tried including Smillie pins, Kirschner wires, screws including mini- or small-fragment cortical screws (2.0–3.5 mm) with countersinking of the head, headless screws like the Herbert screw, and bioabsorbable pins. Fixation can be challenging and may be best done through a safe surgical dislocation using a trochanteric flip osteotomy or through an anterior modified Smith-Peterson approach. Total hip arthroplasty as well as hemiarthroplasty are also advocated for these fractures in certain situation.


Implantology of Fractures of the Head of Femur

May 2022

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76 Reads

Femoral head fractures, also known as Pipkins fractures, are more common in young and are usually caused by high-energy trauma. Controversies in the management of Pipkins fracture still exist between excision, osteosynthesis, and arthroplasty. For internal fixation, multiple implants have been tried including Smillie pins, Kirschner wires, screws including mini- or small-fragment cortical screws (2.0–3.5 mm) with countersinking of the head, headless screws like the Herbert screw, and bioabsorbable pins. Fixation can be challenging and may be best done through a safe surgical dislocation using a trochanteric flip osteotomy or through an anterior modified Smith-Peterson approach. Total hip arthroplasty as well as hemiarthroplasty are also advocated for these fractures in certain situation.


Distal femur non-union fixation: Freshening on bone ends of non-union site, decortication, bone graft and implant placement (LCP) with compression at the site of non-union using Muller's compression device
A 62-year-old female, 33-A3, had surgery elsewhere (3 times before; primary fixation followed by bone grafting 2 times), (A) Anteroposterior (AP) and lateral radiographs showing non-union at her fracture site with implant failure; (B) The AP and lateral radiographs after revision fixation with bone grafting was done with compression achieved via Muller's device and lag screw; (C and D) Radiographs showing intertrochanteric fracture with subtrochanteric extension after 1.5 years, and managed by PFN was done; (E to G) Radiographs and clinical photographs showing union and satisfactory outcome after 31 months
A 51-year-old female with fixation elsewhere (dual plating) referred to us after 16 months of index surgery with stiff knee the surgeon removed the lateral plate (elsewhere). (A) First X-ray available showing distal femur fracture; (B) X-ray after primary surgery elsewhere showing fixation using dual plate; (C and D) X-ray at 12 months, when patient underwent second surgery for stiff knee, and lateral plate removal was done; (E) The medial plate broke and patient presented to us with pain and inability to bear weight after 16 months of index surgery; (F) Immediate post-operative radiographs after revision fixation with bone grafting and compression achieved with one lag screw; (G) Radiographs at 8-months follow-up; (H to J) Radiographs and clinical photographs at 20 months follow-up showing satisfactory outcome
A 75-year-old male patient with 2-year-old non-union supracondylar fracture left femur presented with (A) Anteroposterior (AP) and lateral radiographs after trauma; (B) AP and lateral radiographs after index surgery; (C) AP and lateral radiographs showing non-union after implant (DCS) failure at presentation to us after 2 years of index surgery; (D) Immediate post-operative AP and lateral radiographs after implant removal, decortication, bone grafting fixation using DFLCP, and done; (E) AP and lateral radiographs showing union at 5.5 months; (F to I) Radiographs and clinical pictures showing satisfactory outcome after 2 years and 6 months
(A) A 42-year-old man managed conservatively (elsewhere) presenting with non-union of distal femur fracture after 11 months; (B) Immediate post-operative radiographs after ORIF with DFLP, bone grafting with compression achieved across fracture site; (C) Radiographs showing union at 6 months follow-up; (D to H) Radiographs and clinical photographs at 30-months follow-up showing satisfactory outcome
The Management of Aseptic Non-unions of Distal Femur Fractures with Anatomical Lateral Locking Plates

January 2022

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53 Reads

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3 Citations

Background Distal femoral non-unions are challenging, and frequently associated with short distal fragments, poor bone stock, and with issues from previous implants. Materials and methods A retrospective study of 31 patients admitted with distal femoral non-unions treated using anatomical lateral locking plates. Non-union scores were used. The Knee Society and Neer's scores were used for the comparison of results. The mean follow-up was 39.5 months (from 24 months to 60 months). Results Stable union was accomplished in all. There was a significant improvement in the average Neer's score (24 preoperative to 82 post-operatively at final follow-up), the Part 1 Knee Society score from an average of 46 preoperatively to 84 post-operatively, and Part 2 Knee Society score from 36 preoperatively to 80 post-operatively. Conclusion Optimal stability, good compression at the non-union site (either by lag screws or a compression device or both), maintaining the axial alignment strictly, freshening of bone ends, using an adequate amount of cortico-cancellous bone graft, respecting the biology along with the correct choice of the implant (including the size) are essential to achieve union at the fracture site. Clinical significance Paying attention to the basic principles of management, good contact, stability and maintaining biology is essential in the treatment of non-union. How to cite this article Mukhopadhaya J, Ranjan R, Sinha AK, et al. The Management of Aseptic Non-unions of Distal Femur Fractures with Anatomical Lateral Locking Plates. Strategies Trauma Limb Reconstr 2022;17(3):137–143.


Citations (10)


... 21 Similar results were reported by Mukhopadhaya et al. in 6 patients with an average age of 54.3 years. 22 Carlock et al. treated 16 patients with PHN at an average age of 59.7 years. Twelve patients had atrophic nonunion, three had hypertrophic nonunion, and one had oligotrophic nonunion. ...

Reference:

Current concepts in the treatment of proximal humerus nonunions: a review
Outcome of Osteosynthesis of Late Presenting Proximal Humerus Nonunion A Case Series Janki Sharan Bhadani

Journal of Orthopaedic Case Reports

... Intuitively, envisioning solely what is usually clinically understood by AP translation between the femur and tibia (i.e. excluding any cross-talk effects entirely) in a healthy subject with intact soft-tissue structures, 7 mm of displacement seems highly plausible, especially considering the proximal tibia has an average AP dimension of about 50 mm 45,46 ). However, notwithstanding the possibility to make further first crude attempts at clinically interpreting REFRAMEd signals, the clinical "accuracy" of the values given by the REFRAMEd kinematic signals is very much open for debate, and additional efforts are certainly needed before any kind of consensus can be reached. ...

Evaluation of Anthropometric Measurements of the Aspect Ratio of Knee in Indian Population and its Correlation with the Sizing of Current Knee Arthroplasty System

Indian Journal of Orthopaedics

... Dynamisation is occasionally attempted as a less invasive method to achieve union in femoral diaphyseal fractures with an axial stable fracture configuration [41,42]. The main surgical technique used is the revision ORIF, which involves osteosynthesis with freshening of bone ends and bone grafting [43,44]. It offers a high chance of achieving union and allows for restoring the joint alignment [43,44]. ...

The Management of Aseptic Non-unions of Distal Femur Fractures with Anatomical Lateral Locking Plates

... These fractures are considered low energy injury and occur mainly in older adults. It could be broadly classified into stable of screws have been described including two screws, three screws (parallel, triangle, inverted triangle, Biplane double-supported screw fixation design) and four screws (quadrangular/diamond,) [15][16][17][18][19]. Cancellous screws are considered a less invasive alternative to other internal fixation methods and hip arthroplasty, resulting in lesser operative time, blood loss and morbidity alongside possibly offering better preservation of femoral head blood supply [20]. ...

Implantology of Fractures of the Neck of Femur
  • Citing Chapter
  • May 2022

... There are reports in the literature on the use of the Masquelet technique [11] in the treatment of bone gaps of the distal radius of infected non-union in children. Single-bone forearm creation generally consists of an osteotomy of the radius as well as the ulna, then fixing the radius to the ulna with or without resection of part of one or both bones of the forearm. ...

Masquelet technique for infected distal radius fractures with gaps in paediatric age group

Trauma Case Reports

... Se ha reportado que el uso de la técnica de Masquelet permite lograr excelentes resultados en términos de la restauración de la longitud del hueso y la recuperación de la funcionalidad en pacientes con lesiones secundarias a trauma; además, esta técnica ofrece la posibilidad de realizar un salvamento de la extremidad mediante fijación interna o externa. 6 No obstante, su uso en DO >10cm ha sido escasamente reportado en la literatura, 7,8 por lo que resulta oportuno proponer e implementar modificaciones a la técnica de Masquelet para el manejo de DO de gran tamaño. ...

A case report of extensive segmental defect of the humerus due to thermal necrosis treated with Masquelet technique

Trauma Case Reports

... Literature is divided regarding management of these types of fractures between arthroplasty and osteosynthesis. Many surgeons favor primary arthroplasty even at a young age due to the risk of avascular necrosis, which is as high as 50% as reported by Giannoudis et al. [12] In young patients, however, it may be worth trying to fix these fractures to delay the need for arthroplasty [13]. Fixation can be challenging and may be best done through a safe surgical dislocation using trochanteric flip osteotomy [14,15] (Fig. 2). ...

Functional Outcome of Pipkin Type III Fracture Managed by Osteosynthesis through Trochanteric Flip Osteotomy in a Young Patient after 5 Years Follow-Up – A Case Report and Literature Review

Journal of Orthopaedic Case Reports

... OrthoTV has taken a momentous step with the introduction of virtual fellowships. These immersive programs offer surgeons specialized training in their chosen fields, guided by the nation's most renowned experts [9]. The journey commenced with the primary total knee arthroplasty fellowship, spearheaded by Dr. A. V. Gurava Reddy, a stalwart from Hyderabad. ...

Orthopaedic Research and Education Foundation India, Pandemic and Orthopaedic Education

Journal of Orthopaedic Case Reports

... Depending upon the age of the patient and the fracture type smooth pins, cannulated screws and pediatric hip screw can be various options for the fixation on the neck fractures. Rigid fixation of the shaft using plate and screws is preferred over the flexible nails as these nails may be obstructed by the implants in the neck [2,9]. Our patient had Delbet Type IV fracture with a femur shaft at distal one-third, as it was minimally displaced closed reduction and fixation was done using smooth pins which were later connected to each other by L-rod for more stability and shaft was fixed rigidly with plate and screws. ...

Dilemma for Fracture Fixation of Paediatric Ipsilateral Neck with Shaft Femur Fracture
  • Citing Article
  • January 2021

Indian Journal of Orthopaedics

... It is well known that these factors may have an effect on JL radiological assessment. [22] In their retrospective study comparing TKA applications with GB, MR, and hybrid methods, Hao et al. [10] measured the TTJL. They found that patients in the GB group had more JL elevation compared to patients in the MR and hybrid groups. ...

Joint line restoration in total knee arthroplasty

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John Mukhopadhaya

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Chandrashekhar Yadav

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