John J Stapleton’s research while affiliated with Penn State Hershey Medical Center and Penn State College of Medicine and other places

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Publications (57)


The Diabetic Foot
  • Chapter

March 2022

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33 Reads

Crystal L. Ramanujam

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John J. Stapleton

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Thomas Zgonis

The entire world is witnessing a steady increase in the prevalence of diabetes mellitus, with foot complications encompassing a large burden of the disease. The impact of diabetic foot complications is felt not only personally by the patient but also by their families, healthcare systems, and economies worldwide. Although the best treatment strategies often start with prevention, many physicians and surgeons are directly faced with the challenge of diabetic foot complications long after they have already been present in the patient for some time. Prompt identification of patients at high risk for diabetic foot complications and quick referral to the appropriate specialists are keys to successful clinical outcomes. As uncontrolled hyperglycemia takes its toll on the patient’s body, causing compromise to the circulation and often leading to peripheral sensory neuropathy, a cascade of events may be set in motion leading to foot ulcerations, soft tissue infections, osteomyelitis, amputations, and/or Charcot neuroarthropathy (CN). A strong focus on the appropriate medical and surgical treatment of these clinical entities through a multidisciplinary team may help reduce the overall morbidity and mortality rates associated within this population.KeywordsDiabetic foot infectionsPeripheral arterial diseasePeripheral sensory neuropathyCharcot neuroarthropathyAnkle-brachial indexesDiabetes mellitusOsteomyelitis


Hindfoot Arthrodesis for the Elective and Posttraumatic Foot Deformity

April 2017

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16 Reads

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5 Citations

Clinics in Podiatric Medicine and Surgery

Triple (talonavicular, subtalar, and calcaneocuboid) joint arthrodesis and most recently double (talonavicular and subtalar) joint arthrodesis have been well proposed in the literature for surgical repair of the elective, posttraumatic, and/or neuropathic hindfoot deformities. The articulation of the hindfoot with the ankle and midfoot is multiaxial, and arthrodesis of these joints can significantly alter the lower extremity biomechanical manifestations by providing anatomic correction and alignment. This article reviews the indications and preoperative planning for some of the most common procedures to address the hindfoot deformity.



Operative Fixation Options for Elective and Diabetic Ankle Arthrodesis

April 2017

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17 Reads

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1 Citation

Clinics in Podiatric Medicine and Surgery

Ankle arthrodesis remains one of the most definitive treatment options for end-stage arthritis, paralysis, posttraumatic and postinfectious conditions, failed total ankle arthroplasty, and severe deformities. The general aims of ankle arthrodesis are to decrease pain and instability, correct the accompanying deformity, and create a stable plantigrade foot. Several surgical approaches have been reported for ankle arthrodesis with internal fixation options. External fixation has also evolved for ankle arthrodesis in certain clinical scenarios. This review article provides a comprehensive analysis of midterm to long-term outcomes for ankle arthrodesis using internal and/or external fixation each for elective and diabetic conditions.


Tibialis Anterior Tendon Transfer for Posterior Tibial Tendon Insufficiency

July 2015

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47 Reads

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5 Citations

Clinics in Podiatric Medicine and Surgery

The Cobb procedure is useful for addressing stage 2 posterior tibial tendon dysfunction and is often accompanied by a medial displacement calcaneal osteotomy and/or lateral column lengthening. The Cobb procedure can also be combined with selected medial column arthrodesis and realignment osteotomies along with equinus correction when indicated.


The Diabetic Foot

November 2014

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8 Reads

With the rising prevalence of diabetes mellitus, the impact of foot complications has been recognized worldwide. The potentially devastating effects of this disease have led to substantial personal, social, medical, and economic costs, therefore fueling the search for effective preventative measures and definitive treatment strategies. The main diabetic foot complications include neuropathic ulcerations, infections, amputations, and Charcot deformities. Understanding the pathways to these clinical manifestations provides a foundation for appropriate medical management and surgical intervention when indicated. Many complications are preventable with proper and frequent diabetic foot screenings, patient education in the overall management of diabetes mellitus and its related multi-organ manifestations, and directing high-risk patients into comprehensive treatment programs. Once a diabetic foot complication has ensued, early and aggressive treatment efforts under a multidisciplinary medical and surgical team approach should be targeted at maintaining the patient's function and preserving their quality of life. © 2014 Springer Science+Business Media New York. All rights are reserved.


Supramalleolar Osteotomy and Ankle Arthrodiastasis for Juvenile Posttraumatic Ankle Arthritis

October 2014

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28 Reads

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3 Citations

Clinics in Podiatric Medicine and Surgery

Numerous techniques have been described for posttraumatic ankle arthritis with or without an associated lower extremity deformity in the adult population. These surgical procedures may include, but are not limited to, ankle exostectomy with joint resurfacing, ankle arthrodiastasis, ankle arthroplasty, and ankle arthrodesis. Associated deformities may also be addressed with supramalleolar osteotomies, tibia or fibular lengthening, and calcaneal osteotomies. In juvenile patients, surgical treatment options for posttraumatic ankle arthritis can be challenging, especially when an associated deformity is present. This article describes a combined supramalleolar osteotomy and ankle arthrodiastasis for a juvenile patient with posttraumatic ankle arthritis and valgus deformity.


Surgical Treatment of Tibial Plafond Fractures

October 2014

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49 Reads

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20 Citations

Clinics in Podiatric Medicine and Surgery

Intra-articular fractures of the tibial plafond are typically the result of rotational or axial loading forces, and both mechanisms of injuries can result in an associated fibula fracture. Rotational distal tibial plafond fractures are typically of lower energy and are associated with less articular injury and chondral impaction, whereas axial load injuries of the distal tibial plafond are associated with a higher incidence of intra-articular and soft tissue injury. The goal of this article is to review the mechanisms of injury, fracture patterns, and potential complications associated with the most common presentations of tibial plafond fractures.



Surgical Treatment of Intra-articular Calcaneal Fractures

October 2014

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13 Reads

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15 Citations

Clinics in Podiatric Medicine and Surgery

Most intra-articular calcaneal fractures are a result of high-energy trauma. The operative management of calcaneal fractures has been based on achieving anatomic reduction and minimizing complications of the compromised soft tissue envelope. The traditional extensile lateral approach offers advantages of achieving adequate fracture reduction with the risk of wound-healing complications and infection. Limited open reduction and internal fixation techniques with or without using external fixation focuses on achieving fracture reduction with less risk of wound complications but higher risk of malunion. This article discusses key points of operative management for various intra-articular calcaneal fracture patterns and clinical presentations.


Citations (43)


... [5] For advanced ankle osteoarthropathy, compared with ankle replacement, ankle arthrodesis is one of the most common treatments and is also the gold standard of current treatment. [6,7] Ankle arthrodesis was first proposed in 1879. There are many specific methods of ankle arthrodesis, including traditional open fusion and internal fixation, arthroscopic fusion and internal fixation, minimally invasive small incision fusion and internal fixation, and ankle arthrodesis with external fixation. ...

Reference:

Clinical evaluation of arthrodesis with Ilizarov external fixator for the treatment of end-stage ankle osteoarthritis: A retrospective study
Foot and Ankle Arthrodesis
  • Citing Article
  • April 2017

Clinics in Podiatric Medicine and Surgery

... Currently, there are several approaches and fixation methods to provide solid fusion of the ankle joint. For example, the ankle arthrodesis can be performed through an anterior, medial, posterior, transfibular or combined approach (24). Internal fixation techniques consist of screws, plates or intramedullary nails to provide good joint alignment and stabile fixation (25). ...

Operative Fixation Options for Elective and Diabetic Ankle Arthrodesis
  • Citing Article
  • April 2017

Clinics in Podiatric Medicine and Surgery

... Modifications of bilobed and VYY random advancement flaps are typically utilized for the coverage of submetatarsal ulcers and plantar defects as long as no underlying osteomyelitis is present. 30,31 Local intrinsic muscle flap is a good alternative for plantar weightbearing wounds or osteomyelitic wounds that have been surgically debrided. The common muscle flaps used in the foot are the flexor digitorum brevis, abductor hallucis, abductor digiti minimi, and extensor digitorum brevis muscles. ...

Local and distant pedicled flaps for soft tissue reconstruction of the diabetic foot: A stepwise approach with the use of external fixation
  • Citing Article
  • January 2009

... The most significant risk factor for the concurrent occurrence of CN and osteomyelitis is a pre-existing ulceration in a patient with established neuropathy, which has been shown to increase the risk of limb loss dramatically. Furthermore, a severely dislocated and unstable foot or ankle due to CN also acts as a predisposing factor for the development of osteomyelitis, even though the most common cause of superinfection in this scenario is the critical initial contamination of a local ulceration site (1,2) . ...

Diabetic Charcot Neuroarthropathy of the Foot and Ankle with Osteomyelitis
  • Citing Article
  • October 2014

Clinics in Podiatric Medicine and Surgery

... Surgical treatment of ankles damaged by JIA is a complex dilemma. As surgical treatments have not been described in JIA there is only evidence from other clinical scenarios such as adults with osteoarthritis [12] or joint damage due to trauma in children [16]. ...

Supramalleolar Osteotomy and Ankle Arthrodiastasis for Juvenile Posttraumatic Ankle Arthritis
  • Citing Article
  • October 2014

Clinics in Podiatric Medicine and Surgery

... Calcaneal fractures represent a significant challenge in orthopedic trauma, accounting for approximately 2% of all fractures and 60-65% of all tarsal fractures in adults [1][2][3]. These injuries are predominantly caused by highenergy trauma, such as falls from height or motor vehicle accidents, with 80-90% of affected patients being young to middle-aged males [4]. ...

Surgical Treatment of Intra-articular Calcaneal Fractures
  • Citing Article
  • October 2014

Clinics in Podiatric Medicine and Surgery

... The stabilization achieved must be strong, capable of both resisting varus stress and restoring the antero-posterior and lateral axes of the tibial distal extremity as well as the foot's external rotation. Any filling of bone substance requires autografting or bone substitutes 12 . The stability of the fixation, according to the extent of the fracture, along with the congruence of the articular surface and the axial alignment of the tibio-talar joint, seems to be an important predictor of functional outcomes 1,2,13-16 . ...

Surgical Treatment of Tibial Plafond Fractures
  • Citing Article
  • October 2014

Clinics in Podiatric Medicine and Surgery

... The demographics of atraumatic or spontaneous TAT ruptures, based on 38 reported cases in 14 articles, show they most commonly occur in the elderly (age greater than 60 years) and occur in men more than women [9,11,24,32,43,48,57,63,66,67,71,[77][78][79]. The majority of articles surmised that spontaneous TAT ruptures occur through gradual weakening, overuse and degeneration of the tendon [43,57]. ...

Simultaneous Surgical Repair of a Tibialis Anterior Tendon Rupture and Diabetic Charcot Neuroarthropathy of the Midfoot A Case Report
  • Citing Article
  • October 2013

Clinics in Podiatric Medicine and Surgery

... In our study satisfactory healing was attained in 33.18 and 45.58 days as compared to 22.8 day and 42.8 days in a study done by Mc Callon et al. The percentage decrease in surface area of wounds in our study were 43.75% and 25.15% in the modified VAC group to control group compared to 28.4% and 9.5% by Mc callon et al. (22) The patients in group A had a 55.41% decrease in wound depth compared to 26.94% in group B vs 59% and 8% in a study by Ramanujam et al. (23) In our study VAC therapy group had better healing, had significantly lower 'In-Patient' days. VAC therapy is a cost-effective and relatively safe non-invasive procedure with better outcome in terms of meeting the endpoints as incomplete closure of wounds or till skin graft ability of wound is achieved. ...

Negative-pressure wound therapy in the management of diabetic Charcot foot and ankle wounds
  • Citing Article
  • Full-text available
  • September 2013

Diabetic Foot & Ankle