John H. Postlethwaite's research while affiliated with University of Oregon and other places

Publications (3)

Article
The BMP family of polypeptide growth factors has been shown to play diverse roles in establishing embryonic patterning and tissue fates. We report the cloning of the zebrafish homologue of BMP-2, examine its expression during embryogenesis, and find that it is localized to the distal end of the long arm of zebrafish chromosome 20. A missense mutati...
Article
The BMP family of polypeptide growth factors has been shown to play diverse roles in establishing embryonic patterning and tissue fates. We report the cloning of the zebrafish homologue of BMP-2, examine its expression during embryogenesis, and find that it is localized to the distal end of the long arm of zebrafish chromosome 20. A missense mutati...

Citations

... Four mutations were found to disrupt genes required in Nodal signaling in the endoderm: a mix-family protein (bonnie and clyde, bon), a sox-related gene (casanova, cas), gata5 (faust, fau), and an EGF-CFC-related gene (oneeyed pinhead, oep; Ransom et al., 1996;Zhang et al., 1998;Alexander et al., 1999;Gritsman et al., 1999;Reiter et al., 1999;Kikuchi et al., 2000Kikuchi et al., , 2001Dichmeis et al., 2001). A genetic pathway has begun to emerge in which oep and bmp2 (bone morphogenic protein 2/swirl; Kishimoto et al., 1997;Lee et al., 1998) regulate gata5/fau expression in cardiac precursors to influence cardiac migration and myocardial differentiation (Reiter et al., 2001b), while fau and bon work in parallel pathways upstream of cas to regulate endodermal cell fate Reiter et al., 2001a;Aoki et al., 2002). Implantation of wild-type endoderm into cas embryos rescues cardia bifida and further demonstrates that endodermal Nodal signaling is required for normal heart formation from mesodermal tissue (David and Rosa, 2001). ...
... bmp6, bmp7b [32,33]) are co-expressed in the zebrafish apical ectodermal fold. In addition, expression of bmp2a, bmp2b, bmp4 and bmp7 is up-regulated in the epithelium of the developing caudal fin fold [29-32]. The AER of tetrapod limbs also expresses a number of Bmp genes (reviewed in [34]). ...