John H. Childers’s research while affiliated with University of Texas Southwestern Medical Center and other places

... The chance of treatment failure in monotherapy has been reported to be higher than in combined treatment, so the medical treatment should include dual or triple regimens of antibiotics [1,10]. In addition, some scholars mentioned orchiectomy as the standard option for the treatment of Brucella orchitis, followed by oral tetracycline for about six weeks with intramuscular streptomycin for two weeks to decrease the relapses [2,11]. In a study by Kaya et al., the findings of nine cases with brucellar orchi-epididymitis have been summarized, and the primary management in six cases was orchiectomy [4]. ...

Reference:

Brucella orchitis presenting as a testicular mass mimicking a testicular tumor: a rare case report

... Amyloidosis is an uncommon condition characterized by the deposition of abnormal β-sheet fibrillar proteins in various organs including the kidneys, spleen, and liver [1][2]. It is found less commonly in the genitourinary tract, particularly in the urethra; fewer than 60 cases of urethral amyloidosis have been described in the literature [3][4]. Urethral amyloidosis can present at any age; but, it is mostly found in males with initial presenting symptoms including hematuria, dysuria, urethral discharge, penile induration or masses, and gross urethral bleeding [4][5]. ...

Reference:

Urethral Amyloidosis in a Patient with IgA Nephropathy After Renal Transplant