John F. Chandler’s scientific contributions

What is this page?

This page lists works of an author who doesn't have a ResearchGate profile or hasn't added the works to their profile yet. It is automatically generated from public (personal) data to further our legitimate goal of comprehensive and accurate scientific recordkeeping. If you are this author and want this page removed, please let us know.

Publications (1)

Estimating Per-Locus Mutation Rates
  • Article

January 2006

·

53 Reads

·

25 Citations

John F. Chandler

Relative per-locus mutation rates for Y-DNA microsatellites, and also for mitochondrial DNA single- nucleotide polymorphisms, can be estimated directly from diverse collections of haplotypes without segregating population components. The calibrated average mutation rates for the FTDNA panels of 12, 25, and 37 loci are 0.00187±0.00028, 0.00278±0.00042, and 0.00492±0.00074, respectively, from a collection of haplotypes from Y-Search. The individual per-locus rates are given here.

Citations (1)

... By chrY comparison within the genealogical pairs, average and individual Y-STR mutation rates with their 95% confidence intervals were calculated based on the frequentist approach through direct counting of the number of observed Y-STR differences divided by the total number of meioses [77]. Results were compared to previously defined mutability rates from literature using the Chi-square test [14,48,78,79]. Previously identified influencing molecular factors (repeat size, repeat motif length and repeat type) could be further investigated. ...

Reference:

CSYseq: The first Y-chromosome sequencing tool typing a large number of Y-SNPs and Y-STRs to unravel worldwide human population genetics
Estimating Per-Locus Mutation Rates
  • Citing Article

  • January 2006

John F. Chandler