John Eng’s research while affiliated with Austin Health and other places

What is this page?


This page lists works of an author who doesn't have a ResearchGate profile or hasn't added the works to their profile yet. It is automatically generated from public (personal) data to further our legitimate goal of comprehensive and accurate scientific recordkeeping. If you are this author and want this page removed, please let us know.

Publications (1)


In vivo imaging of cellular proliferation in renal cell carcinoma using 18F-fluorothymidine PET
  • Article
  • Full-text available

April 2014

·

43 Reads

·

12 Citations

·

Sze Ting Lee

·

Carmel Murone

·

[...]

·

Andrew M Scott

Objectives: The ability to measure cellular proliferation non-invasively in renal cell carcinoma may allow prediction of tumour aggressiveness and response to therapy. The aim of this study was to evaluate the uptake of 18F-fluorothymidine (FLT) PET in renal cell carcinoma (RCC), and to compare this to 18F-fluorodeoxyglucose (FDG), and to an immunohistochemical measure of cellular proliferation (Ki-67). Methods: Twenty seven patients (16 male, 11 females; age 42-77) with newly diagnosed renal cell carcinoma suitable for resection were prospectively enrolled. All patients had preoperative FLT and FDG PET scans. Visual identification of tumour using FLT PET compared to normal kidney was facilitated by the use of a pre-operative contrast enhanced CT scan. After surgery tumour was taken for histologic analysis and immunohistochemical staining by Ki-67. Results: The SUVmax (maximum standardized uptake value) mean±SD for FLT in tumour was 2.59±1.27, compared to normal kidney (2.47±0.34). The mean SUVmax for FDG in tumour was similar to FLT (2.60±1.08). There was a significant correlation between FLT uptake and the immunohistochemical marker Ki-67 (r=0.72, P<0.0001) in RCC. Ki-67 proliferative index was mean ± SD of 13.3%±9.2 (range 2.2% - 36.3%). Conclusion: There is detectable uptake of FLT in primary renal cell carcinoma, which correlates with cellular proliferation as assessed by Ki-67 labelling index. This finding has relevance to the use of FLT PET in molecular imaging studies of renal cell carcinoma biology.

Download

Citations (1)


... 18 F-FLT PET/CT has been used for differentiation of benign and malignant tumors, assessment of treatment response, and prediction of prognosis in different malignancies.107,108 Wong et al. prospectively performed preoperative 18 F-FLT PET on 27 cases of RCC.109 A significant correlation between 18 F-FLT uptake and K i -67 (R = 0.72) was observed, thus 18 F-FLT PET/CT could be a useful indicator of tumor proliferation in RCC. ...

Reference:

Molecular Imaging of Renal Cell Carcinoma in Precision Medicine
In vivo imaging of cellular proliferation in renal cell carcinoma using 18F-fluorothymidine PET