Johan E.T. van Hylckama Vlieg's research while affiliated with Kaleido Biosciences and other places

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Publications (6)

Fig. 1 Analytical pipeline and description of glycan compositions and...
Fig. 2 Effects of glycans on fecal community metabolic output and...
Fig. 3 Enteric pathogen growth in pure culture and relative abundances...
Fig. 6 Glycan effects in mouse models of DSS colitis and C. difficile...
Synthetic glycans control gut microbiome structure and mitigate colitis in mice
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  • Dec 2022
Relative abundances of bacterial species in the gut microbiome have been linked to many diseases. Species of gut bacteria are ecologically differentiated by their abilities to metabolize different glycans, making glycan delivery a powerful way to alter the microbiome to promote health. Here, we study the properties and therapeutic potential of chem...
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THE SYNTHETIC GLYCAN KB295 OPTIMIZES MICROBIOME COMPOSITION AND FUNCTION IN ULCERATIVE COLITIS – RESULTS FROM A PROOF OF PRINCIPLE HUMAN STUDY
Article
  • Jan 2022
The pathogenesis of ulcerative colitis (UC) involves genetic susceptibility, immune-mediated tissue injury and environmental factors including disturbances of the gut microbiota. Nearly all current approved therapies modify host immunity, rather than directly targeting the microbiota. Fecal microbiota transplantation provides encouraging evidence f...
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Figure 1. Primary and secondary end points. (A) Mean Lewis score per...
Figure 2. Tertile stratification of ulceration. (A, C, and E) Median...
Figure 3. (A) Mean serum concentrations of PGE 2 per visit and (B) AUC...
Overview of Trial Adverse Events
Bifidobacterium breve Bif195 Protects Against Small-Intestinal Damage Caused by Acetylsalicylic Acid in Healthy Volunteers
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  • May 2019
Background & aims: Enteropathy and small-intestinal ulcers are common adverse effects of nonsteroidal anti-inflammatory drugs such as acetylsalicylic acid (ASA). Safe, cytoprotective strategies are needed to reduce this risk. Specific bifidobacteria might have cytoprotective activities, but little is known about these effects in humans. We used se...
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Understanding mode of action can drive the translational pipeline towards more reliable health benefits for probiotics
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  • Apr 2019
p>The different levels of knowledge described in a translational pipeline (the connection of molecular mechanisms with pre-clinical physiological and human health effects) are not complete for many probiotics. At present, we are not in a position to fully understand the mechanistic basis of many well established probiotic health benefits which, in...
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Citations

... As an intricate ecosystem, the gut has a large and diverse microbial community known as the gut microbiota. 17,18 The human gut microbiota contains probiotics and pathogenic bacteria that coexist harmoniously in a healthy body. However, this balance can be disrupted by abnormal environmental factors and genetic variations. ...
Reference: P2X4 receptor modulates gut inflammation and favours microbial homeostasis in colitis
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... Furthermore, the gut's bacterial communities' composition seems to exert influence on aspirin metabolism. While oral antibiotic administration can decrease the gut microbiota's metabolic activity by slowing its degradation, increasing its bioavailability and prolonging its anti-thrombotic action, probiotics containing Bifidobacterium breve Bif195 bacteria can protect against an aspirin intake adverse reaction, such as intestinal wall damage and aspirin-induced gastric ulcers [135,136]. ...
Reference: The Implication of the Gut Microbiome in Heart Failure
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... The permeability measurements in this study were inspired by previous studies showing that L. rhamnosus CNCM-I 3690 (the strain that was also used here) could restore impaired intestinal barrier functions in mice [27,28]. The lack of confirmatory observations in the present cohort of ileostomists may be due to the fact that contrary to the studies using mouse models, the ileostomists participating in this study did not suffer from impaired mucosal barrier function, minimising the potential of dietary interventions to elicit an improvement, illustrative of translational difficulties across different mammalian models [45]. ...
Reference: Endogenous small intestinal microbiome determinants of transient colonisation efficiency by bacteria from fermented dairy products: a randomised controlled trial
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