Joghee Aravindaraj’s research while affiliated with JSS College of Pharmacy and other places

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Publications (2)

Figure 1. Structure of dexchlorpheniramine and simvastatin.  
Table 1. Precision studies of dexchlorpheniramine maleate samples (ng.ml -1 ). 
Figure 2. LC-MS chromatogram of blank plasma sample. Figure 3. LC-MS chromatogram of dexchlorpheniramine maleate and internal standard sample.  
Figure 2. LC-MS chromatogram of blank plasma sample. Figure 3. LC-MS chromatogram of dexchlorpheniramine maleate and internal standard sample.  
Figure 4. Mass spectrum of dexchlorpheniramine maleate in positive mode Scan.  
Development and Application of a Validated Liquid Chromatography-Mass Spectrometry Method for the Determination of Dexchlorpheniramine Maleate in …
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January 2007

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837 Reads

Joghee Aravindaraj

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Raju

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Suresh Bhojraj

A convenient liquid chromatographic-single Quadrupole mass spectrometric (LC-MS) method was developed and validated for dexchlorpheniramine maleate (INN name: chlorphenamine) determination in human plasma. The need for just a single liquid-liquid extraction with ethyl acetate and being highly sensitive were the advantages of this method. The linearity was also excellent over the range of 1 to 150 ng.ml -1 of dexchlorpheniramine maleate concentration. The method was statistically validated for its selectivity, linearity, precision and robustness. This method was successfully applied to the analysis of chlorpheniramine maleate in clinical studies.

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Figure 1. Structure of dexchlorpheniramine and simvastatin.
Table 1 . Precision studies of dexchlorpheniramine maleate samples (ng.ml -1 ).
Figure 2. LC-MS chromatogram of blank plasma sample. Figure 3. LC-MS chromatogram of dexchlorpheniramine maleate and internal standard sample.
Table 2 . Stability of dexchlorpheniramine maleate in human plasma samples.
Figure 4. Mass spectrum of dexchlorpheniramine maleate in positive mode Scan.
… and Application of a Validated Liquid Chromatography-Mass Spectrometry Method for the Determination of Dexchlorpheniramine Maleate in Human Plasma

January 2007

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655 Reads

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5 Citations

Joghee Aravindaraj

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Raju

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Suresh Bhojraj

A convenient liquid chromatographic-single Quadrupole mass spectrometric (LC-MS) method was developed and validated for dexchlorpheniramine maleate (INN name: chlorphenamine) determination in human plasma. The need for just a single liquid-liquid extraction with ethyl acetate and being highly sensitive were the advantages of this method. The linearity was also excellent over the range of 1 to 150 ng.ml -1 of dexchlorpheniramine maleate concentration. The method was statistically validated for its selectivity, linearity, precision and robustness. This method was successfully applied to the analysis of chlorpheniramine maleate in clinical studies.

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Citations (1)

... The development of medication formulations containing active Dexchlorpheniramine maleate (DXC) and excipients is critical for correct DXC activity. Some methods were successfully established to determine DXC [4,5,6]. It is commonly acknowledged that chromatographic methods need vast volumes of hazardous organic solvents, laborious operations, sometimes requiring expensive detectors, and timeconsuming processes. ...

Reference:

Determination of Antihistamine in Tablets Preparation by Fluorescence Quenching Method
… and Application of a Validated Liquid Chromatography-Mass Spectrometry Method for the Determination of Dexchlorpheniramine Maleate in Human Plasma
Joghee Aravindaraj

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Raju

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Suresh Bhojraj