Jingyi Zhao's research while affiliated with Boston University and other places
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Publications (3)
s> Heterotrimeric G-proteins are signaling switches broadly divided into four families based on the sequence and functional similarity of their Gα subunits: Gs, Gi/o, Gq/11 and G12/13. Artificial mutations that activate Gα subunits of each of these families have long been known to induce oncogenic transformation in experimental systems. With the ad...
Besides being regulated by G protein-coupled receptors, the activity of heterotrimeric G proteins is modulated by many cytoplasmic proteins. GIV/Girdin and DAPLE are the best characterized members of a group of cytoplasmic regulators that contain a Gα-binding-and-activating (GBA) motif and whose dysregulation underlies human diseases, including can...
Citations
... The mechanism of Gα classical signaling is to inhibit the cAMP-dependent pathway by inhibiting adenylate cyclase. The reduced production of cAMP in ATP results in decreased cAMP-dependent protein kinase activity, and mutations in Gα subunits lead to specific cancers [26]. Additionally, many cancer cells abnormally express GPCRs, including those from lung, prostate, colon, pancreas, and mesenchymal cancer cells, which stimulate cell proliferation, migration, invasion, and angiogenesis [27]. ...
... The Dvl-and Gα i -binding domains of Daple are dispensable for Daple-mediated MT organization activity Daple has been reported to both trigger Gα i protein activation through the Gα binding and activating (GBA) motif (Aznar et al., 2015;Leyme et al., 2017;Aznar et al., 2018;Marivin et al., 2020) and interact with Dvl and PARD3 through a PDZ-binding motif (PBM; Fig. 5 A; Oshita et al., 2003;Ishida-Takagishi et al., 2012;Ear et al., 2020). To investigate whether the GBA motif and PBM influence Daple-dependent accumulation and stabilization of apical MTs, we performed rescue analyses of Daple in Daple-KO MTECs using a lentivirus expression system. ...
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