Jing Han's research while affiliated with Jilin University and other places

Publications (13)

Article
Full-text available
Quantification of ultra-trace analytes in complex biological samples using micro-solid-phase extraction followed by direct detection with internal extractive electrospray ionization mass spectrometry (μSPE–iEESI–MS) was demonstrated. 1-Hydroxypyrene (1-OHP) and papaverine at attomole levels in human raw urine samples were analyzed under negative an...
Article
Full-text available
In this study, a facile method based on molecularly imprinted polymers (MIPs) combined with internal extractive electrospray ionization tandem mass spectrometry (iEESI-MS/MS) was developed for the quantitative analysis of fluoroquinolones (FQs) in environmental water samples. FQ molecules in water samples were captured by the MIPs, which was retain...
Article
It is of sustainable interest to improve the sensitivity and selectivity of the ionization process, especially for direct analysis of complex samples without matrix separation. Herein, four ambient ionization methods including desorption atmospheric pressure chemical ionization (DAPCI), heat-assisted desorption atmospheric pressure chemical ionizat...
Article
A novel microextraction method, termed microwave-assisted ionic liquid/ionic liquid dispersive liquid-liquid microextraction has been developed for the rapid enrichment and analysis of triazine herbicides in fruit juice samples by high-performance liquid chromatography. Instead of using hazardous organic solvents, two kinds of ionic liquids, a hydr...
Article
Desorption electrospray ionization (DESI) is the most popular ambient ionization technique for direct analysis of complex samples without sample pretreatment. However, for many applications, especially for trace analysis, it is of interest to improve the sensitivity of DESI-mass spectrometry (MS). In traditional DESI-MS, a mixture of methanol/water...
Article
A miniature thermal dissociation atmospheric chemical ionization (TDCI) source, coupled with LTQ-MS, has been developed for rapid trace detection of pesticide residues such as dimethoate in highly viscous fruit juice samples. Instead of toxic organic solvents and the high electric field used in the conventional ionizations, an ionic liquid, a "gree...
Article
Full-text available
Unlike the extractive electrospray ionization (EESI) technique described elsewhere, a corona discharge instead of electrospray ionization has been utilized to charge a neutral solvent spray under ambient conditions for the generation of highly charged microdroplets, which impact a neutral sample plume for the extractive ionization of the analytes i...
Article
A thermal dissociation atmospheric chemical ionization (TDCI) source was developed for the rapid chemical ionization of ambient analytes in complex matrices. The performance of TDCI has been experimentally explored by coupling the TDCI source to a commercial LTQ XL mass spectrometer, and the dissociation of chemical reagents, for example ionic liqu...
Article
Plant research and natural product detection are of sustainable interests. Benefited by direct detection with no sample preparation, sinapine, a bioactive chemical usually found in various seeds of Brassica plants, has been unambiguously detected in radish taproot (Raphanus sativus) tissue using a liquid-assisted surface desorption atmospheric pres...
Article
Full-text available
Aerosol drugs dominate a significant share of pharmaceutical preparations on the market. A novel sensitive method utilizing nano extractive electrospray ionization mass spectrometry (nanoEESI-MS) has been developed for the rapid analysis of aerosol drug samples with quantitative information. Without any sample pretreatment, aerosol drugs were manua...
Article
Because of its significant advantages including minimal sample pretreatment, easy ambient sample manipulation, high sensitivity, high specificity, and high throughput, desorption electrospray ionization tandem mass spectrometry (DESI-MS(n)) has been successfully applied for the fast nondestructive detection of carcinogenic aromatic amines on variou...

Citations

... Based on this, an on-line analysis device was built to help monitor the reaction using an ambient mass spectrometry technique which allowed direct analysis of various analytes without sample preparation. 34,35 As a representative newly emerging ambient mass spectrometry analysis technique, EESI-MS has the advantages of high sensitivity, fast analysis and avoidance of matrix inuences. 24,25,[36][37][38] Therefore, it is ideal for real-time monitoring of the phenol degradation process without being inuenced by extremely high concentrations of chloride. ...
... In such case, SPE was conducted using a commercial Oasis HLB cartridge and a MIP sorbent connected in series which resulted in cleaner urine extracts that were directly injected into a mass spectrometer [67]. In this scenario, selected fluoroquinolones were determined in environmental water samples using MIPs combined with internal extractive electrospray ionization tandem mass spectrometry, resulting in shorter analysis times of less than three minutes per sample [141]. A similar SPE concept to the one reported elsewhere [67], where two sorbents were used for the extraction of enrofloxacin from urine as well as norfloxacin, enrofloxacin and ciprofloxacin from tissue samples (particularly pig liver) followed by analysis with liquid chromatography equipped with UV detector was reported [89]. ...
... 46 Since then, electrospray ionization mass spectrometer (ESI-MS) and other derived ESI-MS based technologies have gained wider use for the detection of a complex matrix. [47][48][49][50] In our study here, we used ESI-MS to establish a detection method and study the intermediate products of a complex system, namely the DBS solution degraded by C. vulgaris. First, a light simulation system was built to simulate a natural water system. ...
... Similarly, under the optimal microwave extraction conditions of 200 W applied for 60 s, excellent recoveries were achieved compared to DLLME alone [74]. Most recently, a simple and effective method, namely ultrasound-enhanced temperature-controlled IL-DLLME, was developed for the extraction of five pyrethroid residues in herbal tea [84]. The use of ultrasonication and heating was found to improve the ability of the IL ([C 6 MIM][PF 6 ]) to extract the analytes. ...
... Following the boom of droplet-based technologies and applications, the use of droplets to empower and facilitate microscale separations has found its increasing interest and significance in recent years. Droplet microfluidics was employed for bridging 2D liquid-phase separations [16,17], as well as for chemical separation for cellular analysis [18] and biochemical analysis [19]. Among all strategies to exploit the power of droplets in separation science, dropletinterfaced microscale electrophoresis is an emerging technique in which micro/nanometric droplets are used as a carrier of target analytes between sample treatment and electrokinetic separation steps. ...
... High peak capacities had been reported for one-dimension separations 36-39 but they were usually obtained at high elution pressures and in long separation times. Han et al. 36 employed a meter-long packed nano-LC column and generated a peak capacity of 800 under an elution pressure of 400 bar in more than 10 h. Shen et al. 38 obtained peak capacities of 1000-1500 using a 1379 bar RPLC-MS in greater than 12 h. ...
... Besides DAPCI, other corona-based ambient MS methods are also shown in Fig. 5. Thermal dissociation atmospheric chemical ionization (TDCI) was developed in 2011 by Han et al. 111 Ionic liquids (green solvents) are used to produce reagent ions by thermal dissociation processes; these reagent ions interact with the analytes of the raw samples yielding analyte ions that are transferred to the MS. The original design of this source included two electrode plates assembled in a 90-degree conguration in front of the MS inlet and a heatable sample holder (see Fig. 5b). ...
... The detection of both polar and nonpolar (nonvolatile) compounds was demonstrated. 111 A second design was used by Ouyang et al. 112 for dimethoate in orange juices, achieving a low LOQ (0.9 pg mL À1 ) with no sample workup. Nevertheless, the authors reported some constraints of the technique due to the use of ILs, such as the possible contamination of the ion source with the continued used of these solvents and their high proton affinity, which hinders its application. ...
... [16] Other additives have also been successfully used as reactive DESI-MS agents, such as chloride ions in the detection of explosives, [17] hydroxylamine for detecting anabolic steroids in urine, [18] alkylamines in drug detection, [19] and betaine aldehyde for cholesterol detection in rat brain imaging. [20] Additives as diverse as organic compounds [21] and proteins [22] have also been used to enhance the detection of analytes. Most of these reactants showed an improvement in detection of the targeted metabolites by improving their ionisation properties via noncovalent [19] or covalent reactions. ...
... Note that indole has high PA (933.4 kJ/mol), but it gives radical cations rather than the protonated molecules in this study, probably because indole has a low IE (7.76 eV) and no suitable site to accept the proton in our experimental conditions. Moreover, The ion production is largely related to the unique process of ambient corona discharge, which probably produces energetic species such as water radical cations, nitrogen radical cation, etc 12 . Figure 4 shows the time profiles of indole signal from the headspace of cultures with different initial counts of E. coli (10 1 -10 8 CFU/mL). ...