Jin-Ju Jeong's research while affiliated with Kyung Hee University and other places

Publications (9)

Article
Full-text available
In the previous study, we found that flavonoids and ginsenosides exhibited high eliminate rates of human immunodeficiency virus type 1 (HIV-1) D3-transfected macrophages. Based on these findings, here we synthesized the derivatives of gallic acid, including methyl gallate, methyl 4-O-methyl gallate, methyl 3,4-O-dimethyl gallate, and methyl 3,4,5-O...
Article
Full-text available
We investigated the effect of DWac on the gut microbiota composition in mice with 2,3,6-trinitrobenzenesulfonic acid- (TNBS-) induced colitis. Treatment with DWac restored TNBS-disturbed gut microbiota composition and attenuated TNBS-induced colitis. Moreover, we examined the effect of DWac in mice with mesalazine-resistant colitis (MRC). Intrarect...
Article
The anti-inflammatory effects of Th17-inhibiting bacterial strain Lactobacillus sakei OK67 were investigated in DMA/1J mice with collagen II-induced arthritis (CIA). OK67 significantly suppressed IL-6/TGF-β-induced differentiation of splenic T cells into Th17 cells in vitro. Oral administration of OK67 (1 × 109 CFU/mouse) significantly decreased CI...
Article
In a preliminary experiment, majonoside R2 (MR2), isolated from Vietnamese ginseng (Panax vietnamensis Ha et Grushv.), inhibited differentiation to Th17 cells and was metabolized to ocotillol via pseudoginsenoside RT4 (PRT4) by gut microbiota. Therefore, we examined the inhibitory effects of MR2 and its metabolites PRT4 and ocotillol against Th17 c...
Article
We investigated the growth-inhibitory activities of cosmetics and their preservatives against pathogens and resident skin bacteria. Of the tested cosmetics, preservatives such as parabens, 1,2-hexanediol, phenoxyethanol-contained toner, emulsion, cream and baby cream exhibited potent antibacterial effects against Staphylococcus aureus, Escherichia...
Article
Flavonoids, well-documented secondary metabolites in many vegetables and plants, exhibit antiinflammatory, anti-oxidant, anti-microbial, and anticancer activities. However, their cytotoxic effects against human immunodeficiency virus type 1 (HIV-1)-infected cytoprotective macrophages have not been studied. In the present study, we investigated thei...
Article
Ginsenoside Rg1, one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect. In a preliminary study, it was observed that ginsenoside Rg1 was metabolized to 20(S)-protopanaxtriol via ginsenosides Rh1 and F1 by gut microbiota. We further investigated the anti-inflammatory effects of ginsenoside Rg1 and its metabolites in vitro...
Article
Unlabelled: To understand the anti-inflammaging effect of lactic acid bacteria, we selected NF-κB activation-inhibitory Lactobacillus pentosus var. plantarum C29 and investigated its memory-enhancing and anti-inflammatory effects in aged Fischer 344 rats. C29 (2 × 10(9) CFU rat(-1) ), which was orally administered once a day (6 days per week) for...

Citations

... The cell viability of human lymphocytes and other cell lines of diverse tissue origin was not inhibited by EG over a range of cell lines. Gallic acid and its methyl ester are known to have anti-inflammatory [8], antioxidant [27], and anti-cancer properties [5]. Additionally, Ahn et al. [1] proposed that the galloyl function group plays a main role in inhibiting 3'processing of HIV-1 integrase of these compounds. ...
... Maybe reproducing the anaerobic conditions that mimic the gut environment and the effect of host factors cause these differences. AAE suppressed the relative abundance of Proteobacteria, consistent with another study showing that a mixture of A. asphodeloides and Coptis chinensis attenuated high-fat diet-induced colitis in mice [59]. AAE has also been shown to inhibit the growth of harmful bacteria such as Facklamia, Oligella, and Klebsiella, which all have pathogenic effects [60][61][62][63]. ...
... Among the edible probiotics, most are lactobacillus, which has excellent adhesion and colonization characteristics [17], regulates the gut microbiota [18], protects the intestinal mucosa [19], and regulates immunity [20]. Thereby, it shows various physiological activities, such as anti-colitis, antiarthritis, anti-constipation, and anti-hypercholesteremia [21][22][23][24]. Many studies have shown that dietary supplementation of lactobacillus has an anti-obesity effect [25,26], but there is specificity between different strains. ...
... Scientific Committee on Consumer Safety, SCCS) potwierdził ostatnio bezpieczeństwo fenoksyetanolu -dostępne wyniki badań nie wskazują na toksyczność tego związku, zaś jego działanie drażniące wykazane było tylko w badaniach na zwierzętach w stężeniu 200-krotnie wyższym niż dozwolone u ludzi (1%) [15]. Z drugiej jednak strony, wyniki badań Jeong & Kim wykazały, że kosmetyki zawierające w swoim składzie fenoksyetanol mogą hamować wzrost mikrobioty skóry, co może być szczególnie niekorzystne u osób z problemami dermatologicznymi [16]. Kolejną grupą porównywanych składników były glikole, które w kosmetykach pełnią role humektantów, emulgatorów oraz substancji zwiększających lepkość. ...
... 15 MR2 and its metabolites exert anti-inflammatory and antiapoptotic effects against lipopolysaccharide-stimulated inflammation. 16,17 Although the modulation of apoptotic processes and RISK pathway by postconditioning confers powerful protection to HR-exposed cardiac tissue, it is yet to be elucidated if MR2 exerts its cardioprotective effects through these mechanisms. Therefore, this study aimed to determine the role of MR2 in the expression of factors involved in apoptosis and modulation of the RISK pathway in HRstimulated H9C2 cells. ...
... 15 MR2 and its metabolites exert anti-inflammatory and antiapoptotic effects against lipopolysaccharide-stimulated inflammation. 16,17 Although the modulation of apoptotic processes and RISK pathway by postconditioning confers powerful protection to HR-exposed cardiac tissue, it is yet to be elucidated if MR2 exerts its cardioprotective effects through these mechanisms. Therefore, this study aimed to determine the role of MR2 in the expression of factors involved in apoptosis and modulation of the RISK pathway in HRstimulated H9C2 cells. ...
... Jeong and colleagues investigated the cytotoxic effects of oroxylin A and tectorigenin in the CHME5 cells and primary human macrophages infected with HIV-1-D3. These flavonoids exert their effects via reducing the phosphorylation of PI3K, Akt, m-TOR, PDK1, GSK-3β, and Bad in the lipopolysaccharide/cycloheximide treated cells santin suppressed influenza A virus replication in the MDCK and THP-1 infected cells [114]. At the concentration of 60 µM, santin attenuated phosphorylation of p38 MAPK, ERK, JNK/SAPK, and NF-κB [61]. ...
... It has been reported that ginsenoside Rg1 can inhibit the production of the pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and nitric oxide, and that it ameliorates the inflammatory response in colitis model mice (7,10,11). However, it is not yet known whether ginsenoside Rg1 affects the intestinal mucosal epithelial barrier. ...
... Recent evidence has revealed that probiotics can improve cognitive function by alleviating increased inflammatory cytokine level. Namely, Lactobacillus pentosus has been found to improve age-related memory impairment and scopolamine-induced cognitive impairment in vivo (Jeong et al., 2015). Lactobacillus paracasei has been reported to prevent age-related cognitive decline in senescent accelerated prone 8 mice (Corpuz et al., 2018;Huang et al., 2018). ...