Jie Zhang’s research while affiliated with Shanghai Jiao Tong University and other places

Current bionic hands lack the ability of fine force manipulation for grasping fragile objects due to missing human neuromuscular compliance in control. This incompatibility between prosthetic devices and the sensorimotor system has resulted in a high abandonment rate of hand prostheses. To tackle this challenge, we employed a neuromorphic modeling approach, biorealistic control, to regain human-like grasping ability. The biorealistic control restored muscle force regulation and stiffness adaptation using neuromorphic modeling of the neuromuscular reflex units, which was capable of real-time computing of model outputs. We evaluated the dexterity of the biorealistic control with a set of delicate grasp tasks that simulated varying challenging scenarios of grasping fragile objects in daily activities of life, including the box and block task, the glass box task, and the potato chip task. The performance of the biorealistic control was compared with that of proportional control. Results indicated that the biorealistic control with the compliance of the neuromuscular reflex units significantly outperformed the proportional control with more efficient grip forces, higher success rates, fewer break and drop rates. Post-task survey questionnaires revealed that the biorealistic control reduced subjective burdens of task difficulty and improved subjective confidence in control performance significantly. The outcome of the evaluation confirmed that the biorealistic control could achieve superior abilities in fine, accurate, and efficient grasp control for prosthetic users.

Current bionic hands lack the ability of fine force manipulation for grasping fragile objects due to missing human neuromuscular compliance in control. This incompatibility between prosthetic devices and the sensorimotor system has resulted in a high abandonment rate of hand prostheses. To tackle this challenge, we employed a neuromorphic modeling approach, biorealistic control, to regain human-like grasping ability. The biorealistic control restored muscle force regulation and stiffness adaptation using neuromorphic modeling of the neuromuscular reflex units, which was capable of real-time computing of model outputs. We evaluated the dexterity of the biorealistic control with a set of delicate grasp tasks that simulated varying challenging scenarios of grasping fragile objects in daily activities of life, including the Box and Block Task, the Glass Box Task, and the Potato Chip Task. The performance of the biorealistic control was compared with that of proportional control. Results indicated that the biorealistic control with the compliance of the neuromuscular reflex units significantly outperformed the proportional control with more efficient grip forces, higher success rates, fewer break and drop rates. Post-task survey questionnaires revealed that the biorealistic control reduced subjective burdens of task difficulty and improved subjective confidence in control performance significantly. The outcome of the evaluation confirmed that the biorealistic control could achieve superior abilities in fine, accurate, and efficient grasp control for prosthetic users.

This study develops biomimetic strategies for slip prevention in prosthetic hand grasps. The biomimetic system is driven by a novel slip sensor, followed by slip perception and preventive control. Here, we show that biologically inspired sensorimotor pathways can be restored between the prosthetic hand and users. A Ruffini endings-like slip sensor is used to detect shear forces and identify slip events directly. The slip information and grip force are encoded into a bi-state sensory coding that evokes vibration and buzz tactile sensations in subjects with transcutaneous electrical nerve stimulation (TENS). Subjects perceive slip events under various conditions based on the vibration sensation and voluntarily adjust grip force to prevent further slipping. Additionally, short-latency compensation for grip force is also implemented using a neuromorphic reflex pathway. The reflex loop includes a sensory neuron and interneurons to adjust the activations of antagonistic muscles reciprocally. The slip prevention system is tested in five able-bodied subjects and two transradial amputees with and without reflex compensation. A psychophysical test for perception reveals that the slip can be detected effectively, with a success accuracy of 96.57%. A slip protection test indicates that reflex compensation yields faster grasp adjustments than voluntary action, with a median response time of 0.30 (0.08) s, a rise time of 0.26 (0.03) s, an execution time of 0.56 (0.07) s, and a slip distance of 0.39 (0.10) cm. Prosthetic grip force is highly correlated to that of an intact hand, with a correlation coefficient of 96.85% (2.73%). These results demonstrate that it is feasible to reconstruct slip biomimetic sensorimotor pathways that provide grasp stability for prosthetic users.

The ability of a novel biorealistic hand prosthesis for grasp force control reveals improved neural compatibility between the human-prosthetic interaction. The primary purpose here was to validate a virtual training platform for amputee subjects and evaluate the respective roles of visual and tactile information in fundamental force control tasks. We developed a digital twin of tendon-driven prosthetic hand in the MuJoCo environment. Biorealistic controllers emulated a pair of antagonistic muscles controlling the index finger of the virtual hand by surface electromyographic (sEMG) signals from amputees’ residual forearm muscles. Grasp force information was transmitted to amputees through evoked tactile sensation (ETS) feedback. Six forearm amputees participated in force tracking and holding tasks under different feedback conditions or using their intact hands. Test results showed that visual feedback played a predominant role than ETS feedback in force tracking and holding tasks. However, in the absence of visual feedback during the force holding task, ETS feedback significantly enhanced motor performance compared to feedforward control alone. Thus, ETS feedback still supplied reliable sensory information to facilitate amputee’s ability of stable grasp force control. The effects of tactile and visual feedback on force control were subject-specific when both types of feedback were provided simultaneously. Amputees were able to integrate visual and tactile information to the biorealistic controllers and achieve a good sensorimotor performance in grasp force regulation. The virtual platform may provide a training paradigm for amputees to adapt the biorealistic hand controller and ETS feedback optimally.

Sensory feedback provides critical interactive information for the effective use of hand prostheses. Non-invasive neural interfaces allow convenient access to the sensory system, but they communicate a limited amount of sensory information. This study examined a novel approach that leverages a direct and natural sensory afferent pathway, and enables an evoked tactile sensation (ETS) of multiple digits in the projected finger map (PFM) of participants with forearm amputation non-invasively. A bidirectional prosthetic interface was constructed by integrating the non-invasive ETS-based feedback system into a commercial prosthetic hand. The pressure information of five fingers was encoded linearly by the pulse width modulation range of the buzz sensation. We showed that simultaneous perception of multiple digits allowed participants with forearm amputation to identify object length and compliance by using information about contact patterns and force intensity. The ETS enhanced the grasp-and-transport performance of participants with and without prior experience of prosthetic use. The functional test of transport-and-identification further revealed improved execution in classifying object size and compliance using ETS-based feedback. Results demonstrated that the ETS is capable of communicating somatotopically compatible information to participants efficiently, and improves sensory discrimination and closed-loop prosthetic control. This non-invasive sensory interface may establish a viable way to restore sensory ability for prosthetic users who experience the phenomenon of PFM.

It has been shown that prostaglandin (PG) E2 synthesized in the lateral parabrachial nucleus (LPBN) is involved in lipopolysaccharide-induced fever. But the neural mechanisms of how intra-LPBN PGE2 induces fever remain unclear. In this study, we investigated whether the LPBN-preoptic area (POA) pathway, the thermoafferent pathway for feed-forward thermoregulatory responses, mediates fever induced by intra-LPBN PGE2 in male rats. The core temperature (Tcore) was monitored using a temperature radiotelemetry transponder implanted in rat abdomen. We showed that microinjection of PGE2 (0.28 nmol) into the LPBN significantly enhanced the density of c-Fos-positive neurons in the median preoptic area (MnPO). The chemical lesioning of MnPO with ibotenate or selective genetic lesioning or inhibition of the LPBN-MnPO pathway significantly attenuated fever induced by intra-LPBN injection of PGE2. We demonstrated that EP3 receptor was a pivotal receptor for PGE2-induced fever, since microinjection of EP3 receptor agonist sulprostone (0.2 nmol) or EP3 receptor antagonist L-798106 (2 nmol) into the LPBN mimicked or weakened the pyrogenic action of LPBN PGE2, respectively, but this was not the case for EP4 and EP1 receptors. Whole-cell recording from acute LPBN slices revealed that the majority of MnPO-projecting neurons originating from the external lateral (el) and dorsal (d) LPBN were excited and inhibited, respectively, by PGE2 perfusion, initiating heat-gain and heat-loss mechanisms. The amplitude but not the frequency of spontaneous and miniature glutamatergic excitatory postsynaptic currents (sEPSCs and mEPSCs) in MnPO-projecting LPBel neurons increased after perfusion with PGE2; whereas the frequency and amplitude of spontaneous inhibitory postsynaptic currents (sIPSCs) and the A-type potassium (IA) current density did not change. In MnPO-projecting LPBd neurons, neither sEPSCs nor sIPSCs responded to PGE2; however, the IA current density was significantly increased by PGE2 perfusion. These electrophysiological responses and the thermoeffector reactions to intra-LPBN PGE2 injection, including increased brown adipose tissue thermogenesis, shivering, and decreased heat dissipation, were all abolished by L-798106, and mimicked by sulprostone. These results suggest that the pyrogenic effects of intra-LPBN PGE2 are mediated by both the inhibition of the LPBd-POA pathway through the EP3 receptor-mediated activation of IA currents and the activation of the LPBel-POA pathway through the selective enhancement of glutamatergic synaptic transmission via EP3 receptors.

Introduction Either non-invasive somatotopic or substitute sensory feedback is capable of conveying a single modality of sensory information from prosthetic hands to amputees. However, the neurocognitive ability of amputees to integrate multi-modality sensory information for functional discrimination is unclear. The purpose of this study was to assess the fusion of non-invasive somatotopic tactile and substitute aperture feedbacks for profile perception of multiple physical features during grasping objects. Methods Two left transradial amputees with somatotopic evoked tactile sensation (ETS) of five fingers participated in the study. The tactile information of prosthetic hand was provided to amputees by the ETS feedback elicited on the stump projected finger map. Hand aperture information was conveyed to amputees with substitute electrotactile stimulation on the forearm or upper arm. Two types of sensory feedback were integrated to a commercial prosthetic hand. The efficacy of somatotopic ETS feedback on object length identification task was assessed with or without substitute aperture stimulation. The object size identification task was utilized to assess how ETS stimulation at the stump may affect aperture perception with stimulation on the ipsilateral upper arm or forearm. Finally, the task of identifying combined length and size was conducted to evaluate the ability of amputees to integrate the dual modalities of sensory feedback for perceiving profile features. Results The study revealed that amputee subjects can effectively integrate the ETS feedback with electrotactile substitutive feedback for object profile discrimination. Specifically, ETS was robust to provide object length information with electrotactile stimulation at either the forearm or upper arm. However, electrotactile stimulation at the upper arm for aperture perception was less susceptible to the interference of ETS stimulation than at the forearm. Discussion Amputee subjects are able to combine somatotopic ETS and aperture feedbacks for identifying multi-dimensional features in object profiling. The two sensory streams of information can be fused effectively without mutual interference for functional discrimination.

Type 2 diabetes (T2D) is a major health and economic burden worldwide. Despite the availability of multiple drugs for short-term management, sustained remission of T2D is currently not achievable pharmacologically. Intracerebroventricular administration of fibroblast growth factor 1 (icvFGF1) induces sustained remission in T2D rodents, propelling intense research efforts to understand its mechanism of action. Whether other FGFs possess similar therapeutic benefits is currently unknown. Here, we show that icvFGF4 also elicits a sustained antidiabetic effect in both male db/db mice and diet-induced obese mice by activating FGF receptor 1 (FGFR1) expressed in glucose-sensing neurons within the mediobasal hypothalamus. Specifically, FGF4 excites glucose-excited (GE) neurons while inhibiting glucose-inhibited (GI) neurons. Moreover, icvFGF4 restores the percentage of GI neurons in db/db mice. Importantly, intranasal delivery of FGF4 alleviates hyperglycemia in db/db mice, paving the way for non-invasive therapy. We conclude that icvFGF4 holds significant therapeutic potential for achieving sustained remission of T2D.