Jie Tan's research while affiliated with Kaleido Biosciences and other places

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Publications (6)

Fig. 1 Analytical pipeline and description of glycan compositions and...
Fig. 2 Effects of glycans on fecal community metabolic output and...
Fig. 3 Enteric pathogen growth in pure culture and relative abundances...
Fig. 6 Glycan effects in mouse models of DSS colitis and C. difficile...
Synthetic glycans control gut microbiome structure and mitigate colitis in mice
Article
Full-text available
  • Dec 2022
Relative abundances of bacterial species in the gut microbiome have been linked to many diseases. Species of gut bacteria are ecologically differentiated by their abilities to metabolize different glycans, making glycan delivery a powerful way to alter the microbiome to promote health. Here, we study the properties and therapeutic potential of chem...
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Modulation of the Gut Microbiome by Novel Synthetic Glycans for the Production of Propionate and the Reduction of Cardiometabolic Risk Factors
Preprint
Full-text available
  • Apr 2022
Background Increasing evidence indicates that an altered gut microbiome participates in the development of cardiometabolic syndrome and associated risk factors, such as insulin resistance, dyslipidemia, and obesity, and that targeting the gut microbiome is a promising strategy to lower the risk for cardiometabolic diseases. Part of this reduction i...
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Synthetic glycans that control gut microbiome structure mitigate colitis in mice
Preprint
Full-text available
  • Jan 2022
Relative abundances of bacterial species in the gut microbiome have been linked to many diseases. Species of gut bacteria are ecologically differentiated by their abilities to metabolize different glycans, making glycan delivery a powerful way to alter the microbiome to promote health. We describe the properties and therapeutic potential of chemica...
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Citations

... We found that the relative abundance of Lactobacillus was obviously raised by lactulose fermentation, but there was no significant difference between groups by using both in vitro system and mice model. This is consistent with the previous studies, which showed that lactulose treatment increased the relative abundance of Bifidobacterium and Lactobacillus but the change mainly occurred in Bifidobacterium (Tolonen et al., 2022;Vanhoutte, De Preter, De Brandt, Verbeke, Swings, & Huys, 2006). Streptococcus is considered to be likely associated with the occurrence and development of colitis (Heidarian, Noormohammadi, Aghdaei, & Alebouyeh, 2017). ...
Reference: Regulatory effect of lactulose on intestinal flora and serum metabolites in colitis mice: In vitro and in vivo evaluation
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